대한한의학회지 (The Journal of Korean Medicine)

  • 제41권3호
  • /
  • Pages.138-150
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  • 2020
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  • 1010-0695(pISSN)
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  • 2288-3339(eISSN)
대한한의학회 (The Society of Korean Medicine)
권호 표지
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증미오비탕이 Monosodium Iodoacetate 유발 관절연골손상에 미치는 영향

Effects of Jeungmiobi-tang on the Articular Cartilage Injuries Induced by Monosodium Iodoacetate in Rats

  • 현재철 (세명대학교 한의과대학 한방재활의학과교실) ;
  • 정수현 (세명대학교 한의과대학 한방재활의학과교실)
  • Hyun, Jae-Cheol (Department of Rehabilitation medicine of Korean Medicine, College of Korean Medicine, Se-Myung University) ;
  • Jeong, Su-Hyeon (Department of Rehabilitation medicine of Korean Medicine, College of Korean Medicine, Se-Myung University)
  • 투고 : 2020.07.31
  • 심사 : 2020.08.19
  • 발행 : 2020.09.01
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초록

Objectives: This study was carried out to investigate the protective effects of Jeungmiobi-tang on the articular cartilage injuries induced by monosodium iodoacetate in rats. Methods: Twenty four rats were divided into three groups. Rats of normal group (n=8) were injected with 0.1 ml physiological saline into both knee joint cavities. In the rats of control group (n=8) and Jeungmiobi-tang group (n=8), Arthritis was induced by injecting with 0.1 ml monosodium iodoacetate (5 mg/ml) into both knee joint cavities. After the experiment, Gross and histopathological examinations on the knee joint were performed. The content of proteoglycan in articular cartilage and TNF-α and IL-1β in synovial fluid were also analyzed. Results: Grossly, Injuries to the articular cartilage surface was observed weak in the Jeungmiobi-tang group compared to the control group. Proteoglycan content in the articular cartilage was significantly higher in the Jeungmiobi-tang group than in the control group. The chondrocyte score was significantly lower in the Jeungmiobi-tang group than in the control group. Conclusion: According to these results, that Jeungmiobi-tang has protective effects on the articular cartilage injuries induced by monosodium iodoacetate in rats.

키워드

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