Fisheries and Aquatic Sciences

The Korean Society of Fisheries and Aquatic Science (한국수산과학회)
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Ishige okamurae reduces blood glucose levels in high-fat diet mice and improves glucose metabolism in the skeletal muscle and pancreas

  • Yang, Hye-Won (Department of Marine Life Science, School of Marine Biomedical Sciences, Jeju National University) ;
  • Son, Myeongjoo (Department of Anatomy & Cell Biology, Gachon University College of Medicine) ;
  • Choi, Junwon (Department of Anatomy & Cell Biology, Gachon University College of Medicine) ;
  • Oh, Seyeon (Functional Cellular Networks Laboratory, Lee Gil Ya Cancer and Diabetes Institute, Gachon University) ;
  • Jeon, You-Jin (Department of Marine Life Science, School of Marine Biomedical Sciences, Jeju National University) ;
  • Byun, Kyunghee (Department of Anatomy & Cell Biology, Gachon University College of Medicine) ;
  • Ryu, Bo Mi (Department of Marine Life Science, School of Marine Biomedical Sciences, Jeju National University)
  • Received : 2020.05.21
  • Accepted : 2020.07.24
  • Published : 2020.09.30
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Abstract

Brown alga (Ishige okamurae; IO) dietary supplements have been reported to possess anti-diabetic properties. However, the effects of IO supplements have not been evaluated on glucose metabolism in the pancreas and skeletal muscle. C57BL/6 N male mice (age, 7 weeks) were arranged in five groups: a chow diet with 0.9% saline (NFD/saline group), high-fat diet (HFD) with 0.9% saline (HFD/saline group). high-fat diet with 25 mg/kg IO extract (HFD/25/IOE). high-fat diet with 50 mg/kg IO extract (HFD/50/IOE), and high-fat diet with 75 mg/kg IO extract (HFD/75/IOE). After 4 weeks, the plasma, pancreas, and skeletal muscle samples were collected for biochemical analyses. IOE significantly ameliorated glucose tolerance impairment and fasting and 2 h blood glucose level in HFD mice. IOE also stimulated the protein expressions of the glucose transporters (GLUTs) including GLUT2 and GLUT4 and those of their related transcription factors in the pancreases and skeletal muscles of HFD mice, enhanced glucose metabolism, and regulated blood glucose level. Our results suggest Ishige okamurae extract may reduce blood glucose levels by improving glucose metabolism in the pancreas and skeletal muscle in HFD-induced diabetes.

Keywords

References

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