Anxiety and mood (대한불안의학회지)

Korean Academy of Anxiety Disorders (대한불안의학회)
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The Uncinate Fasciculus Sub-Tract Connecting Face-Specific Regions in Patients with Social Anxiety Disorder : A Preliminary Study

사회불안장애 환자의 얼굴 관련 영역을 잇는 갈고리다발 하부경로 : 예비연구

  • Kang, Bongsuk (Department of Psychiatry, Seoul National University Hospital) ;
  • Lee, YoonJi Irene (Department of Psychiatry, Seoul National University Hospital) ;
  • Lee, Jae-Yeon (Department of Psychiatry, Seoul National University Hospital) ;
  • Choi, Soo-Hee (Department of Psychiatry, Seoul National University Hospital)
  • 강봉석 (서울대학교병원 정신건강의학과) ;
  • 이윤지 (서울대학교병원 정신건강의학과) ;
  • 이재연 (서울대학교병원 정신건강의학과) ;
  • 최수희 (서울대학교병원 정신건강의학과)
  • Received : 2020.07.08
  • Accepted : 2020.09.28
  • Published : 2020.10.30
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Abstract

Objective : Social anxiety disorder (SAD) is characterized by fear of social threat and exhibits limbic hyper-reactivity toward social stimuli such as emotional faces. A previous study identified the uncinate fasciculus (UF) sub-tract as particularly related to facial memory. To explore the white matter tract relating to face-specific brain regions, we investigated the UF sub-tract in SAD. Methods : The diffusion tensor images of 22 patients with SAD and 20 healthy controls were analyzed with tractography. The UF sub-tract was delineated using the regions of interest of face patches in the anterior temporal lobe and the orbitofrontal cortex, and fractional anisotrophy (FA) and total number of streamlines (ST) were analyzed. We examined the group comparison of FA and ST of the UF sub-tract and correlations of FA and ST with the social anxiety symptoms such as the Liebowitz Social Anxiety Scale (LSAS), the Social Interaction Anxiety Scale (SIAS), the Social Phobia Scale (SPS) and the Fear of Negative Evaluation scale (FNE) in SAD. Results : There were no group differences in FA and ST of the UF sub-tract. However, negative correlations were observed between ST of the right UF sub-tract and severity of social anxiety symptoms (LSAS, rs=-0.480, p=0.024; SIAS, rs=-0.580, p=0.005; SPS, rs=-0.590, p=0.004; FNE, rs=-0.675, p=0.001) in patients with SAD. Conclusion : Although patients with SAD did not show quantitative abnormalities in the UF sub-tact connecting face-specific brain regions, this structure seems to play a role in the symptom severity of SAD.

Keywords

Acknowledgement

본 연구는 2017년도 정부(교육부)의 재원으로 한국연구재단의 지원을 받아 수행된 기초연구사업임(NRF-2017R1D1A1B03036385, http://www.nrf.re.kr).

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