Journal of Korean Neurosurgical Society

The Korean Neurosurgical Society (대한신경외과학회)
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Change of Pyogenic and Tuberculous Spondylitis between 2007 and 2016 Year : A Nationwide Study

  • Kim, Yeon Jee (Department of Neurosurgery, Bundang CHA Medical Center, CHA University College of Medicine) ;
  • Hong, Je Beom (Department of Neurosurgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine) ;
  • Kim, Yeo Song (Department of Neurosurgery, Cheongju St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Yi, Jeeeun (Department of Public Health Science, Graduate School of Public Health, Seoul National University) ;
  • Choi, Jung Min (Department of Medical Device Management and Research, SAIHST, Sungkyunkwan University) ;
  • Sohn, Seil (Department of Neurosurgery, Bundang CHA Medical Center, CHA University College of Medicine)
  • Received : 2020.01.15
  • Accepted : 2020.03.25
  • Published : 2020.11.01
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Abstract

Objective : We attempted to compare the incidence of pyogenic spondylitis (PS) and tuberculous spondylitis (TS) between 2007 and 2016. Furthermore, we investigated the patients who underwent surgery in 2016 compared to that in 2007. Methods : We used a nationwide database managed by the Korean National Health Insurance Service (NHIS) in 2007 and 2016. Total 9655 patients with a newly diagnosis of PS or TS were enrolled in PS or TS group. Among them, 1721 patients underwent either fusion or decompression surgery. We analyzed demographic distribution of patients according to gender and age and year of diagnosis. Results : Comparing between 2007 and 2016, the incidence of PS has increased in 2016 than in 2007 (4874 vs. 2431, p<0.0001). Conversely, declination of incidence of TS was discovered in 2016 compared to 2007 (594 vs. 1756, p<0.0001). Females showed predominance over males regarding both PS and TS (5228 vs. 4427, p<0.0001). Among them, the number of PS patients who underwent surgery increased significantly in 2016 relative to that in 2007 (979 vs. 592, p<0.0001). Conclusion : This nationwide study suggests that PS may increase and TS may decrease in Korea. In addition, demand for surgery regarding PS may increase.

Keywords

References

  1. Aagaard T, Roed C, Dragsted C, Skinhoj P : Microbiological and therapeutic challenges in infectious spondylodiscitis: a cohort study of 100 cases, 2006-2011. Scand J Infect Dis 45 : 417-424, 2013 https://doi.org/10.3109/00365548.2012.753160
  2. Ahn JS, Lee JK : Diagnosis and treatment of tuberclous spondylitis and pyogenic spondylitis in atypical cases. Asian Spine J 1 : 75-79, 2007 https://doi.org/10.4184/asj.2007.1.2.75
  3. Akiyama T, Chikuda H, Yasunaga H, Horiguchi H, Fushimi K, Saita K : Incidence and risk factors for mortality of vertebral osteomyelitis: a retrospective analysis using the Japanese diagnosis procedure combination database. BMJ Open 3 : e002412, 2013 https://doi.org/10.1136/bmjopen-2012-002412
  4. Cegielski JP, McMurray DN : The relationship between malnutrition and tuberculosis: evidence from studies in humans and experimental animals. Int J Tuberc Lung Dis 8 : 286-298, 2004
  5. Cheung WY, Luk KD : Pyogenic spondylitis. Int Orthop 36 : 397-404, 2012 https://doi.org/10.1007/s00264-011-1384-6
  6. Colmenero JD, Jimenez-Mejias ME, Sanchez-Lora FJ, Reguera JM, Palomino-Nicas J, Martos F, et al. : Pyogenic, tuberculous, and brucellar vertebral osteomyelitis: a descriptive and comparative study of 219 cases. Ann Rheum Dis 56 : 709-715, 1997 https://doi.org/10.1136/ard.56.12.709
  7. Cottle L, Riordan T : Infectious spondylodiscitis. J Infect 56 : 401-412, 2008 https://doi.org/10.1016/j.jinf.2008.02.005
  8. Fantoni M, Trecarichi EM, Rossi B, Mazzotta V, Di Giacomo G, Nasto LA, et al. : Epidemiological and clinical features of pyogenic spondylodiscitis. Eur Rev Med Pharmacol Sci 16 Suppl 2 : 2-7, 2012
  9. Forrester DM : Infectious spondylitis. Semin Ultrasound CT MR 25 : 461-473, 2004 https://doi.org/10.1053/j.sult.2004.09.003
  10. Gouliouris T, Aliyu SH, Brown NM : Spondylodiscitis: update on diagnosis and management. J Antimicrob Chemother 65 Suppl 3 : iii11-iii24, 2010
  11. Grammatico L, Baron S, Rusch E, Lepage B, Surer N, Desenclos JC, et al. : Epidemiology of vertebral osteomyelitis (VO) in France: analysis of hospitaldischarge data 2002-2003. Epidemiol Infect 136 : 653-660, 2008 https://doi.org/10.1017/S0950268807008850
  12. Guttmann OP, Rahman MS, O'Mahony C, Anastasakis A, Elliott PM : Atrial fibrillation and thromboembolism in patients with hypertrophic cardiomyopathy: systematic review. Heart 100 : 465-472, 2014 https://doi.org/10.1136/heartjnl-2013-304276
  13. Jensen AG, Espersen F, Skinhoj P, Rosdahl VT, Frimodt-Moller N : Increasing frequency of vertebral osteomyelitis following Staphylococcus aureus bacteraemia in Denmark 1980-1990. J Infect 34 : 113-118, 1997 https://doi.org/10.1016/S0163-4453(97)92395-1
  14. Jeong SJ, Choi SW, Youm JY, Kim HW, Ha HG, Yi JS : Microbiology and epidemiology of infectious spinal disease. J Korean Neurosurg Soc 56 : 21-27, 2014 https://doi.org/10.3340/jkns.2014.56.1.21
  15. Kehrer M, Pedersen C, Jensen TG, Lassen AT : Increasing incidence of pyogenic spondylodiscitis: a 14-year population-based study. J Infect 68 : 313-320, 2014 https://doi.org/10.1016/j.jinf.2013.11.011
  16. Kim CJ, Kim EJ, Song KH, Choe PG, Park WB, Bang JH, et al. : Comparison of characteristics of culture-negative pyogenic spondylitis and tuberculous spondylitis: a retrospective study. BMC Infect Dis 16 : 560, 2016 https://doi.org/10.1186/s12879-016-1897-0
  17. Lee DH, Choi YJ, Han IB, Hong JB, Do Han K, Choi JM, et al. : Association of ischemic stroke with ankylosing spondylitis: a nationwide longitudinal cohort study. Acta Neurochir (Wien) 160 : 949-955, 2018. https://doi.org/10.1007/s00701-018-3499-7
  18. Lee DH, Choi YJ, Han IB, Hong JB, Do Han K, Choi JM, et al. : Correction to: Association of ischemic stroke with ankylosing spondylitis: a nationwide longitudinal cohort study. Acta Neurochir (Wien) 160 : 957-958, 2018 https://doi.org/10.1007/s00701-018-3518-8
  19. Lee KY : Comparison of pyogenic spondylitis and tuberculous spondylitis. Asian Spine J 8 : 216-223, 2014 https://doi.org/10.4184/asj.2014.8.2.216
  20. Lora-Tamayo J, Euba G, Narvaez JA, Murillo O, Verdaguer R, Sobrino B, et al. : Changing trends in the epidemiology of pyogenic vertebral osteomyelitis: the impact of cases with no microbiologic diagnosis. Semin Arthritis Rheum 41 : 247-255, 2011 https://doi.org/10.1016/j.semarthrit.2011.04.002
  21. Noh SH, Zhang HY, Lee SH, Choi JK, Chin DK : Changes in trends of spondylitis in Korea based on a nationwide database. Yonsei Med J 60 : 487-489, 2019 https://doi.org/10.3349/ymj.2019.60.5.487
  22. Park CJ, Choi YJ, Kim JG, Han IB, Do Han K, Choi JM, et al. : Association of acute myocardial infarction with ankylosing spondylitis: a nationwide longitudinal cohort study. J Clin Neurosci 56 : 34-37, 2018 https://doi.org/10.1016/j.jocn.2018.08.008
  23. Pigrau C, Almirante B, Flores X, Falco V, Rodriguez D, Gasser I, et al. : Spontaneous pyogenic vertebral osteomyelitis and endocarditis: incidence, risk factors, and outcome. Am J Med 118 : 1287, 2005
  24. Pigrau C, Rodriguez-Pardo D, Fernandez-Hidalgo N, Moreto L, Pellise F, Larrosa MN, et al. : Health care associated hematogenous pyogenic vertebral osteomyelitis: a severe and potentially preventable infectious disease. Medicine (Baltimore) 94 : e365, 2015 https://doi.org/10.1097/MD.0000000000000365
  25. Skaf GS, Domloj NT, Fehlings MG, Bouclaous CH, Sabbagh AS, Kanafani ZA, et al. : Pyogenic spondylodiscitis: an overview. J Infect Public Health 3 : 5-16, 2010 https://doi.org/10.1016/j.jiph.2010.01.001
  26. Sohn S, Chung CK, Han KD, Jung JH, Hyeun JH, Kim J, et al. : A nationwide study of surgery in a newly diagnosed spine metastasis population. J Korean Neurosurg Soc 62 : 46-52, 2019 https://doi.org/10.3340/jkns.2017.0304
  27. Sohn S, Chung CK, Jung JH, Lee KC, Kim J, Chang UK, et al. : Nationwide comparative study of synchronous and metachronous spine metastasis in the adult Korean population. J Clin Neurosci 57 : 33-37, 2018 https://doi.org/10.1016/j.jocn.2018.08.048
  28. Sohn S, Kim J, Chung CK, Lee NR, Chang UK, Sohn MJ : A nationwide study of stereotactic radiosurgery in a newly diagnosed spine metastasis population. Stereotact Funct Neurosurg 95 : 189-196, 2017 https://doi.org/10.1159/000475764
  29. Sohn S, Kim J, Chung CK, Lee NR, Park E, Chang UK, et al. : A nationwide epidemiological study of newly diagnosed spine metastasis in the adult Korean population. Spine J 16 : 937-945, 2016 https://doi.org/10.1016/j.spinee.2016.03.006
  30. Sohn S, Kim J, Chung CK, Lee NR, Park E, Chang UK, et al. : Nationwide epidemiology and healthcare utilization of spine tumor patients in the adult Korean population, 2009-2012. Neurooncol Pract 2 : 93-100, 2015
  31. Sohn S, Kim J, Chung CK, Lee NR, Sohn MJ, Kim SH : A nation-wide epidemiological study of newly diagnosed primary spine tumor in the adult Korean population, 2009-2011. J Korean Neurosurg Soc 60 : 195-204, 2017 https://doi.org/10.3340/jkns.2016.0505.011
  32. Torda AJ, Gottlieb T, Bradbury R : Pyogenic vertebral osteomyelitis: analysis of 20 cases and review. Clin Infect Dis 20 : 320-328, 1995 https://doi.org/10.1093/clinids/20.2.320
  33. Waldvogel FA, Vasey H : Osteomyelitis: the past decade. N Engl J Med 303 : 360-370, 1980 https://doi.org/10.1056/NEJM198008143030703