Journal of Ceramic Processing Research

  • 제21권5호
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  • Pages.515-523
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  • 2020
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  • 1229-9162(pISSN)
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  • 2672-152X(eISSN)
한양대학교 세라믹연구소 (Ceramic Processing Research Center)
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Nitrilotriacetic acid functionalization on Fe3O4 nanoparticle via amino and carboxylic functionalization

  • Jin Soon Han (Division of Materials Science and Engineering, Hanyang University) ;
  • MiRae Youm (Division of Materials Science and Engineering, Hanyang University) ;
  • Hyun-Hee Choi (School of Materials Science and Engineering, Changwon National University) ;
  • Yeon-Gil Jung (School of Materials Science and Engineering, Changwon National University) ;
  • Sung-Churl Choi (Division of Materials Science and Engineering, Hanyang University) ;
  • Gye Seok An (Division of Materials Science and Engineering, Hanyang University)
  • 투고 : 2020.02.03
  • 심사 : 2020.04.07
  • 발행 : 20200000
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초록

Since chelating chemical had focused for enhancing bio-susceptibility and ability for the binding with biomaterials, in this study, Nitrilotiriacetic acid (NTA) was utilized for the developing chelate ligand attached superparamagnetic nanoparticle. In order to conjugate NTA, carboxylic group was needed on the surface of substrate particle for building peptide bond with amine group which was branched from the NTA structure. Therefore Fe3O4 nanoparticle was functionalized with various of amine precursor (Polyethyleneimine (PEI), (3-Aminopropyl)triethoxysilane (APTES)), and carboxyl precursor (Polyacrylic acid (PAA)) before the conjugation of NTA. Then NTA conjugation behavior was estimated which is varied with the type of amine precursor which affects to the surface properties.

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과제정보

This work was supported by "Human Resources Program in Energy Technology" of the KETEP and MOTIE of the Republic of Korea (No. 20194030202450) and by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (2018R1A5A6075959).