The Korean Journal of Physiology and Pharmacology

The Korean Society of Pharmacology (대한약리학회)
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POTASSIUM-DEPENDENT SODIUM/CALCIUM EXCHANGER 3 (NCKX3) DEPLETION LEADS TO ABNORMAL MOTOR FUNCTION AND SOCIAL BEHAVIOR IN MICE

  • D.N. TRAN (Laboratory of Veterinary Biochemistry and Molecular Biology, Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University) ;
  • E.-M. JUNG (Laboratory of Veterinary Biochemistry and Molecular Biology, Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University) ;
  • Y.-M. YOO (Laboratory of Veterinary Biochemistry and Molecular Biology, Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University) ;
  • J.-H. LEE (Laboratory of Veterinary Biochemistry and Molecular Biology, Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University) ;
  • E.-B. JEUNG (Laboratory of Veterinary Biochemistry and Molecular Biology, Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University)
  • Received : 2020.05.24
  • Accepted : 2020.08.27
  • Published : 20200000
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Abstract

Transcellular calcium transport is an essential activity in mineralized tissue formation, including that in nervous systems. Dysregulation of Ca2+ homeostasis can induce excitotoxicity and neurodegeneration in the central nervous system. Nckx3, a potassium-dependent Na+/Ca2+ exchanger, is most abundant in the brain and has a critical role in the transport of intracellular calcium across the cell membrane. However, the roles of Nckx3 in neuron development and function remain unreported. Herein, we examined the behaviors of Nckx3-knock-out mice at the age of six weeks. Detailed behavioral analyses showed Nckx3-/- mice exhibited an increase in moving distances in the open field test. Additionally, the rotarod test revealed motor learning defects in Nckx3-/- mice. Both Nckx3+/- and Nckx3-/- mice also exhibited deficits in sociability and social novelty preference. Furthermore, Nckx3-/- mice displayed increased depression-related behavior. However, there was no significant change in cognition function detected in Nckx3-/- mice. This study demonstrates that NCKX3 is involved in behavior and neuronal function

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Acknowledgement

This research was supported by a Global Research and Development Center (GRDC) Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2017K1A4A3014959 and NRF-2017R1A2B2005031).