DOI QR코드

DOI QR Code

How to approach orthognathic surgery in patients who refuse blood transfusion

  • Lee, Sang Hwan (Department of Plastic and Reconstructive Surgery, Soonchunhyang University College of Medicine) ;
  • Kim, Dong Gyu (Department of Plastic and Reconstructive Surgery, Soonchunhyang University College of Medicine) ;
  • Shin, Ho Seong (Department of Plastic and Reconstructive Surgery, Soonchunhyang University College of Medicine)
  • Received : 2020.03.25
  • Accepted : 2020.07.14
  • Published : 2020.09.15

Abstract

Background Some patients who need surgery refuse a blood transfusion because of their religious beliefs or concerns about blood-borne infections. In recent years, bloodless surgery has been performed successfully in many procedures, and is therefore of increasing interest in orthognathic surgery. Methods Ten Jehovah's Witnesses who visited our bloodless surgery center for orthognathic surgery participated in this study. To maintain hemoglobin (Hb) levels above 10 g/dL before surgery, recombinant erythropoietin (rEPO) was subcutaneously administered and iron supplements were intravenously administered. During surgery, acute normovolemic hemodilution (ANH) and induced hypotensive anesthesia were used. To elevate the Hb levels to >10 g/dL after surgery, a similar method to the preoperative approach was used. Results The 10 patients comprised three men and seven women. Their average Hb level at the first visit was 11.1 g/dL. With treatment according to our protocol, the average preoperative Hb level rose to 12.01 g/dL, and the average Hb level on postoperative day 1 was 10.01 g/dL. No patients needed a blood transfusion, and all patients were discharged without any complications. Conclusions This study presents a way to manage patients who refuse blood transfusions while undergoing orthognathic surgery. rEPO and iron supplementation were used to maintain Hb levels above 10 g/dL. During surgery, blood loss was minimized by a meticulous procedure and induced hypotensive anesthesia, and intravascular volume was maintained by ANH. Our practical approach to orthognathic surgery for Jehovah's Witnesses can be applied to the management of all patients who refuse blood transfusions.

Keywords

References

  1. Sowade O, Warnke H, Scigalla P. Operations with a heart-lung machine in adult members of Jehovah's Witnesses. Anaesthesist 1995;44:257-64. https://doi.org/10.1007/s001010050152
  2. Suess S, Suess O, Brock M. Neurosurgical procedures in Jehovah's Witnesses: an increased risk? Neurosurgery 2001;49:266-73. https://doi.org/10.1227/00006123-200108000-00005
  3. Wittmann PH, Wittmann FW. Total hip replacement surgery without blood transfusion in Jehovah's Witnesses. Br J Anaesth 1992;68:306-7. https://doi.org/10.1093/bja/68.3.306
  4. Li KK, Meara JG, Alexander A Jr. Location of the descending palatine artery in relation to the Le Fort I osteotomy. J Oral Maxillofac Surg 1996;54:822-7. https://doi.org/10.1016/S0278-2391(96)90528-5
  5. Lanigan DT, Hey JH, West RA. Major vascular complications of orthognathic surgery: hemorrhage associated with Le Fort I osteotomies. J Oral Maxillofac Surg 1990;48:561-73. https://doi.org/10.1016/s0278-2391(10)80468-9
  6. Pineiro-Aguilar A, Somoza-Martin M, Gandara-Rey JM, et al. Blood loss in orthognathic surgery: a systematic review. J Oral Maxillofac Surg 2011;69:885-92. https://doi.org/10.1016/j.joms.2010.07.019
  7. Ueki K, Marukawa K, Shimada M, et al. The assessment of blood loss in orthognathic surgery for prognathia. J Oral Maxillofac Surg 2005;63:350-4. https://doi.org/10.1016/j.joms.2004.05.226
  8. Kretschmer W, Koster U, Dietz K, et al. Factors for intraoperative blood loss in bimaxillary osteotomies. J Oral Maxillofac Surg 2008;66:1399-403. https://doi.org/10.1016/j.joms.2008.01.060
  9. Thastum M, Andersen K, Rude K, et al. Factors influencing intraoperative blood loss in orthognathic surgery. Int J Oral Maxillofac Surg 2016;45:1070-3. https://doi.org/10.1016/j.ijom.2016.02.006
  10. Choi WS, Irwin MG, Samman N. The effect of tranexamic acid on blood loss during orthognathic surgery: a randomized controlled trial. J Oral Maxillofac Surg 2009;67:125-33. https://doi.org/10.1016/j.joms.2008.08.015
  11. Olsen JJ, Skov J, Ingerslev J, et al. Prevention of bleeding in orthognathic surgery: a systematic review and meta-analysis of randomized controlled trials. J Oral Maxillofac Surg 2016;74:139-50. https://doi.org/10.1016/j.joms.2015.05.031
  12. Madsen DE, Ingerslev J, Sidelmann JJ, et al. Intraoperative blood loss during orthognathic surgery is predicted by thromboelastography. J Oral Maxillofac Surg 2012;70:e547-52. https://doi.org/10.1016/j.joms.2011.09.013
  13. Shander A, Javidroozi M. The approach to patients with bleeding disorders who do not accept blood-derived products. Semin Thromb Hemost 2013;39:182-90. https://doi.org/10.1055/s-0032-1333541
  14. Scott SN, Boeve TJ, McCulloch TM, et al. The effects of epoetin alfa on transfusion requirements in head and neck cancer patients: a prospective, randomized, placebo-controlled study. Laryngoscope 2002;112(7 Pt 1):1221-9. https://doi.org/10.1097/00005537-200207000-00015
  15. Weber RS, Jabbour N, Martin RC 2nd. Anemia and transfusions in patients undergoing surgery for cancer. Ann Surg Oncol 2008;15:34-45. https://doi.org/10.1245/s10434-007-9502-9
  16. Lynn S, McDaniel J. Managing severe anemia when the patient is a Jehovah's Witness. JAAPA 2013;26:24-9. https://doi.org/10.1097/01720610-201304000-00006
  17. Lin DM, Lin ES, Tran MH. Efficacy and safety of erythropoietin and intravenous iron in perioperative blood management: a systematic review. Transfus Med Rev 2013;27:221-34. https://doi.org/10.1016/j.tmrv.2013.09.001
  18. Bacuzzi A, Dionigi G, Piffaretti G, et al. Preoperative methods to improve erythropoiesis. Transplant Proc 2011;43: 324-6. https://doi.org/10.1016/j.transproceed.2010.09.097
  19. Dixon JL, Smalley MG. Jehovah's Witnesses: the surgical/ethical challenge. JAMA 1981;246:2471-2. https://doi.org/10.1001/jama.1981.03320210037021
  20. Ball AM, Winstead PS. Recombinant human erythropoietin therapy in critically ill Jehovah's Witnesses. Pharmacotherapy 2008;28:1383-90. https://doi.org/10.1592/phco.28.11.1383
  21. Shaw AD, Stafford-Smith M, White WD, et al. The effect of aprotinin on outcome after coronary-artery bypass grafting. N Engl J Med 2008;358:784-93. https://doi.org/10.1056/NEJMoa0707768
  22. Eubanks JD. Antifibrinolytics in major orthopaedic surgery. J Am Acad Orthop Surg 2010;18:132-8. https://doi.org/10.5435/00124635-201003000-00002
  23. Shander A. Acute normovolemic hemodilution (ANH): a practical approach. Transfus Altern Transfus Med 1999;1:7-10. https://doi.org/10.1111/j.1778-428X.1999.tb00016.x
  24. Marsh JC, Bevan DH. Haematological care of the Jehovah's Witness patient. Br J Haematol 2002;119:25-37. https://doi.org/10.1046/j.1365-2141.2002.03639.x