Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
권호 표지
DOI QR코드

DOI QR Code

Beneficial effects of Paeo-tang on cardiovascular and renal function in L-NAME-induced hypertensive rats

파어탕의 L-NAME 유도 고혈압 동물군에서의 혈압강하효과 및 심신기능 개선 효과

  • Na, Se Won (Department of Physiology, College of Oriental Medicine, Wonkwang University) ;
  • Hong, Mi Hyeon (Department of Physiology, College of Oriental Medicine, Wonkwang University) ;
  • Kim, Hye Yoom (Department of Physiology, College of Oriental Medicine, Wonkwang University) ;
  • Jang, Youn Jae (Department of Physiology, College of Oriental Medicine, Wonkwang University) ;
  • Yoon, Jung Joo (Department of Physiology, College of Oriental Medicine, Wonkwang University) ;
  • Lee, Yun Jung (Department of Physiology, College of Oriental Medicine, Wonkwang University) ;
  • Kang, Dae Gill (Department of Physiology, College of Oriental Medicine, Wonkwang University) ;
  • Lee, Ho Sub (Department of Physiology, College of Oriental Medicine, Wonkwang University)
  • 나세원 (원광대학교 한의과대학 생리학교실) ;
  • 홍미현 (원광대학교 한의과대학 생리학교실) ;
  • 김혜윰 (원광대학교 한의과대학 생리학교실) ;
  • 장윤재 (원광대학교 한의과대학 생리학교실) ;
  • 윤정주 (원광대학교 한의과대학 생리학교실) ;
  • 이윤정 (원광대학교 한의과대학 생리학교실) ;
  • 강대길 (원광대학교 한의과대학 생리학교실) ;
  • 이호섭 (원광대학교 한의과대학 생리학교실)
  • Received : 2020.07.31
  • Accepted : 2020.08.23
  • Published : 2020.08.31
Download PDF
⟨ Previous Next ⟩

Abstract

Hypertension has been approved to cause disharmony between the heart and kidney such as cardiac hypertrophy and kidney dysfunction. In traditional oriental medicine Paeo-tang (PET) has been shown to have effects on blood circulation improvement. However, the beneficial effect of PET on hypertension remains unknown. In this study, we investigated that PET attenuates blood pressure and improves cardiovascular and renal function in NG-nitro-L-arginine methylester (L-NAME) rat model. Hypertensive rat models were induced by the administration of L-NAME (40 mg/kg/day) and then PET (50 or 100 mg/kg/day) or Olmetec was treated for 2 weeks. PET treatment significantly suppressed the systolic blood pressure and decreased intima-media thickness in the thoracic aorta. PET ameliorated endothelium-dependent and independent vascular relaxation in the L-NAME-induced vascular dysfunction. PET ameliorated the functional decline in the kidney such as albumin and blood urea nitrogen in plasma. These results demonstrated that PET possesses protective effects against L-NAME-induced hypertension.

Keywords

References

  1. Rahman K, Lowe GM. Garlic and cardiovascular disease: a critical review. J. Nutr, 2006; 136:736S. https://doi.org/10.1093/jn/136.3.736S
  2. Ahn KT, Jin SA, Jeong JO. Diagnosis and Treatment of Hypertension: Based on the Guidelines of the Korean Society of Hypertension, J Korean Neurol Assoc. 2019; 37(2): 123-134. https://doi.org/10.17340/jkna.2019.2.2
  3. Li X, Kang DG, Lee JK, Kim SJ, Choi DH,Lee KB, Cui HZ, Yeom KB, Le HS. Study on the Vasorelaxant Mechanism of the Butanol Extract of Euonymus alatus. Oriental Physiology & Patholog. 2008; 22(1):148-154.
  4. Evgenov OV, Pacher P, Schmidt PM, Hasko G, Schmidt HH, Stasch JP. NO-independent stimulators and activators of soluble guanylate cyclase: Discovery and therapeutic potential. Nat Rev Drug Discov. 2006; 755-768.
  5. Xin Gu, Herrera GA. Expression of eNOS in kidneys from hypertensive patients. Int J Nephrol Renovasc Dis. 2010; 3: 11-19.
  6. You JY, Seol GH, Suh SH, Ahn JH. Regulatory Mechanism of Vascular Contractility by Extracellular K+: Effect on Endothelium-Dependent Relaxation and Vascular Smooth Muscle Contractility. The Korean Journal of Thoracic and Cardiovascular Surgery, 2004;37:210-219.
  7. Kim DH, Lee YJ, Yoon JJ, Lee SM, Kang DG, Lee HS. Effect of Paeotang on tumor necrosis factor ${\alpha}$-induced vascular inflammation in human umbilical vein endothelial cells. Chin J Integr Med. 2017.
  8. Loperena R, Harrison DG.Oxidative Stress and Hypertensive Diseases. Med Clin North Am. 2017; 101(1): 169-193. https://doi.org/10.1016/j.mcna.2016.08.004
  9. Silva BR, Pernomian L, Bendhack LM. Contribution of oxidative stress to endothelial dysfunction in hypertension. Front Physiol. 2012; 3: 441. https://doi.org/10.3389/fphys.2012.00441
  10. Zou AP, Jr Cowely AW. Nitric oxide in renal cortex and medulla: an in vivo microdialysis study. Hypertension. 1997. 29(2): 194-198. https://doi.org/10.1161/01.HYP.29.1.194
  11. Erdely A, Freshour G, Baylis C. Resistance to renal damage by chronic nitric oxide synthase inhibition in the Wistar-Furth rat. Am J Physiol Intergr Comp Physiol. 2006; 290(1):R66-72. https://doi.org/10.1152/ajpregu.00444.2005
  12. Park KH, Park WJ. Endothelial Dysfunction: Clinical Implications in Cardiovascular Disease and Therapeutic Approaches. J Korean Med Sci. 2015; 30(9): 1213-1225. https://doi.org/10.3346/jkms.2015.30.9.1213
  13. Rajendran P, Rengarajan T, Thangavel J, Nishigaki Y, Sakthisekaran D,Sethi G, Nishigaki I. The Vascular Endothelium and Human Diseases. Int J Biol Sci. 2013; 9(10):1057-1069. https://doi.org/10.7150/ijbs.7502
  14. Forte M, Conti V, Damato A, Ambrosio M, Puca AA, Sciarretta S, Frati G, Vecchione C, Carrizzo A. Targeting Nitric Oxide with Natural Derived Compounds as a Therapeutic Strategy in Vascular Diseases. Oxid Med Cell Longev. 2016; 2016: 7364138.
  15. Li Q, Yon JY, Cai H. Mechanisms and Consequences of eNOS Dysfunction in Hypertension. J Hypertens. 2015; 33(6): 1128-1136. https://doi.org/10.1097/HJH.0000000000000587
  16. Faria TO, Targueta GP, Angeli JK, Almeida EA, Stefanon I, Vassallo DV, et al. Acute resistance exercise reduces blood pressure and vascular reactivity, and increases endothelium-dependent relaxation in spontaneously hypertensive rats. Eur J Appl Physiol. 2010; 110(2):359-366. https://doi.org/10.1007/s00421-010-1508-5
  17. Maneesai P,Prasarttong P, Bunbupha S, Kukongviriyapan U, Kukongviriyapan V,Tangsucharit P, Prachaney P, Pakdeechote P. Synergistic Antihypertensive Effect of Carthamus tinctorius L. Extract and Captopril in l-NAME-Induced Hypertensive Rats via Restoration of eNOS and AT1R Expression. Nutrients. 2016; 8(3): 122. https://doi.org/10.3390/nu8030122
  18. Welch WJ. Angiotensin II-dependent superoxide: effects on hypertension and vascular dysfunction. Hypertension. 2008 Jul; 52(1): 51-56. https://doi.org/10.1161/HYPERTENSIONAHA.107.090472
  19. Crowley SD, Gurley SB, Oliverio MI, et al. Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system. J. Clin. Invest. 2005; 115:1092-1099. https://doi.org/10.1172/JCI23378
  20. Sung DJ, So WY, Park HY. Cha KS. Exercise and Hypertension: Review of Nitric Oxide Production and Vasodilation by Exercise. Journal of The Korean Society of Living Environmental System. 2010; 17(2):181-190.