Clinical and Experimental Pediatrics

대한소아청소년과학회 (The Korean Pediatric Society)
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Early preemptive immunomodulators (corticosteroids) for severe pneumonia patients infected with SARS-CoV-2

  • Lee, Kyung-Yil (The Catholic University of Korea College of Medicine) ;
  • Rhim, Jung-Woo (The Catholic University of Korea College of Medicine) ;
  • Kang, Jin-Han (The Catholic University of Korea College of Medicine)
  • 투고 : 2020.02.29
  • 심사 : 2020.04.08
  • 발행 : 2020.04.15
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참고문헌

  1. Jefferson T, Jones M, Doshi P, Spencer EA, Onakpoya I, Heneghan CJ. Oseltamivir for influenza in adults and children: systematic review of clinical study reports and summary of regulatory comments. BMJ 2014;348: g2545. https://doi.org/10.1136/bmj.g2545
  2. Rhim JW, Lee KY, Youn YS, Kang JH, Kim JC. Epidemiological and clinical characteristics of childhood pandemic 2009 H1N1 virus infection: an observational cohort study. BMC Infect Dis 2011;11:225. https://doi.org/10.1186/1471-2334-11-225
  3. Bermejo-Martin JF, Cilloniz C, Mendez R, Almansa R, Gabarrus A, Ceccato A, et al. Lymphopenic community acquired pneumonia (L-CAP), an immunological phenotype associated with higher risk of mortality. EBioMedicine 2017;24:231-6. https://doi.org/10.1016/j.ebiom.2017.09.023
  4. Lee KY, Rhim JW, Kang JH. Hyperactive immune cells (T cells) may be responsible for acute lung injury in influenza virus infections: a need for early immune-modulators for severe cases. Med Hypotheses 2011;76:64-9. https://doi.org/10.1016/j.mehy.2010.08.032
  5. Beutler BA. TLRs and innate immunity. Blood 2009;113:1399-407. https://doi.org/10.1182/blood-2008-07-019307
  6. Matzinger P. The danger model: a renewed sense of self. Science 2002;296:301-5. https://doi.org/10.1126/science.1071059
  7. Lee KY. Pneumonia, acute respiratory distress syndrome, and early immune-modulator therapy. Int J Mol Sci 2017;18: E388.
  8. Lee KY. A common immunopathogenesis mechanism for infectious diseases: the protein-homeostasis-system hypothesis. Infect Chemother 2015;47:12-26. https://doi.org/10.3947/ic.2015.47.1.12
  9. Lee KY. A unified pathogenesis for kidney diseases, including genetic diseases and cancers, by the protein-homeostasis-system hypothesis. Kidney Res Clin Pract 2017;36:132-44. https://doi.org/10.23876/j.krcp.2017.36.2.132
  10. Yang EA, Kang HM, Rhim JW, Kang JH, Lee KY. Early corticosteroid therapy for Mycoplasma pneumoniae pneumonia irrespective of used antibiotics in children. J Clin Med 2019;8:E726.
  11. Blum CA, Nigro N, Briel M, Schuetz P, Ullmer E, Suter-Widmer I, et al. Adjunct prednisone therapy for patients with community-acquired pneumonia: A multicentre, double-blind, randomised, placebo-controlled trial. Lancet 2015;385:1511-8. https://doi.org/10.1016/S0140-6736(14)62447-8
  12. Torres A, Sibila O, Ferrer M, Polverino E, Menendez R, Mensa J et al. Effect of corticosteroids on treatment failure among hospitalized patients with severe community-acquired pneumonia and high inflammatory response: A randomized clinical trial. JAMA 2015;313:677-86. https://doi.org/10.1001/jama.2015.88
  13. Rhim JW, Go EJ, Lee KY, Youn YS, Kim MS, Park SH, et al. Pandemic 2009 H1N1 virus infection in children and adults: a cohort study at a single hospital throughout the epidemic. Int Arch Med 2012;5:13. https://doi.org/10.1186/1755-7682-5-13

피인용 문헌

  1. Immunology of COVID-19: Current State of the Science vol.52, pp.6, 2020, https://doi.org/10.1016/j.immuni.2020.05.002
  2. The solution on enigmas in COVID-19: the protein-homeostasis-system hypothesis vol.63, pp.7, 2020, https://doi.org/10.5124/jkma.2020.63.7.366
  3. Biomaterials-Based Opportunities to Engineer the Pulmonary Host Immune Response in COVID-19 vol.7, pp.5, 2020, https://doi.org/10.1021/acsbiomaterials.0c01287