한국의학물리학회지:의학물리 (Progress in Medical Physics)

  • 제31권2호
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  • Pages.9-19
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  • 2020
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  • 2508-4445(pISSN)
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  • 2508-4453(eISSN)
한국의학물리학회 (Korean Society of Medical Physics)
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Development of a Wide Dose-Rate Range Electron Beam Irradiation System for Pre-Clinical Studies and Multi-Purpose Applications Using a Research Linear Accelerator

  • Jang, Kyoung Won (Research Center, Dongnam Institute of Radiological and Medical Sciences) ;
  • Lee, Manwoo (Research Center, Dongnam Institute of Radiological and Medical Sciences) ;
  • Lim, Heuijin (Research Center, Dongnam Institute of Radiological and Medical Sciences) ;
  • Kang, Sang Koo (Research Center, Dongnam Institute of Radiological and Medical Sciences) ;
  • Lee, Sang Jin (Research Center, Dongnam Institute of Radiological and Medical Sciences) ;
  • Kim, Jung Kee (Research Center, Dongnam Institute of Radiological and Medical Sciences) ;
  • Moon, Young Min (Department of Radiation Oncology, Dongnam Institute of Radiological and Medical Sciences) ;
  • Kim, Jin Young (Department of Radiation Oncology, Dongnam Institute of Radiological and Medical Sciences) ;
  • Jeong, Dong Hyeok (Research Center, Dongnam Institute of Radiological and Medical Sciences)
  • 투고 : 2020.05.15
  • 심사 : 2020.06.12
  • 발행 : 2020.06.30
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초록

Purpose: This study aims to develop a multi-purpose electron beam irradiation device for preclinical research and material testing using the research electron linear accelerator installed at the Dongnam Institute of Radiological and Medical Sciences. Methods: The fabricated irradiation device comprises a dual scattering foil and collimator. The correct scattering foil thickness, in terms of the energy loss and beam profile uniformity, was determined using Monte Carlo calculations. The ion-chamber and radiochromic films were used to determine the reference dose-rate (Gy/s) and beam profiles as functions of the source to surface distance (SSD) and pulse frequency. Results: The dose-rates for the electron beams were evaluated for the range from 59.16 Gy/s to 5.22 cGy/s at SSDs of 40-120 cm, by controlling the pulse frequency. Furthermore, uniform dose distributions in the electron fields were achieved up to approximately 10 cm in diameter. An empirical formula for the systematic dose-rate calculation for the irradiation system was established using the measured data. Conclusions: A wide dose-rate range electron beam irradiation device was successfully developed in this study. The pre-clinical studies relating to FLASH radiotherapy to the conventional level were made available. Additionally, material studies were made available using a quantified irradiation system. Future studies are required to improve the energy, dose-rate, and field uniformity of the irradiation system.

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참고문헌

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피인용 문헌

  1. High-Dose-Rate Electron-Beam Dosimetry Using an Advanced Markus Chamber with Improved Ion-Recombination Corrections vol.31, pp.4, 2020, https://doi.org/10.14316/pmp.2020.31.4.145