Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Renal Lymphoma with Mesenteric Lymphomatosis in a Cat

  • Jeon, Jin-ha (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Song, Doo-won (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Ro, Woong-bin (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Kim, Heyong-seok (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Lee, Ga-won (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Cho, Jun-ho (Goodpapa Animal Hospital) ;
  • Jeong, Woo-chang (Africa Animal Medical Center) ;
  • Kim, Soo-hyeon (Department of Veterinary Pathology, College of Veterinary Medicine, Konkuk University) ;
  • Sur, Jung-hyang (Department of Veterinary Pathology, College of Veterinary Medicine, Konkuk University) ;
  • Park, Hee-myung (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
  • Received : 2020.05.07
  • Accepted : 2020.07.06
  • Published : 2020.08.31
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Abstract

A 6-year-old castrated male Russian Blue cat was presented for evaluation of dyschezia. Abdominal ultrasound revealed hyperechoic nodules in both kidneys, heterogeneous mass in abdomen, and extensive mesenteric thickening with multiple hypoechoic nodules. Computed tomography showed multiple hypodense lesions in both kidneys and diffuse nodular infiltration around the mesentery. Fine needle aspirates (FNA) acquired under ultrasound guidance from the mesentery consisted of large lymphocytes which have round to irregular nuclei with granular chromatin, prominent nucleoli and a small amount of basophilic cytoplasm. Polymerase chain reaction (PCR) for antigen receptor gene rearrangement result of FNA sample revealed a T-cell malignancy. The cat died from acute renal failure after 1 cycle of modified Madison-Wisconsin L-CHOP protocol. Postmortem examination revealed bilaterally enlarged lumpy-bumpy shaped kidneys. Histopathologic examination showed an infiltration of malignant lymphocytes into the renal parenchyma and mesentery. Immunohistochemical staining of the renal sample displayed a negative expression of CD3, PAX5, MUM-1, and CD79. The clinical features and prognosis of the cat with renal lymphoma with mesenteric lymphomatosis have been described in this report.

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References

  1. Benigni L, Lamb CR, Corzo-Menendez N, Holloway A, Eastwood JM. Lymphoma affecting the urinary bladder in three dogs and a cat. Vet Radiol Ultrasound 2006; 47: 592-596.
  2. Cooper C, Jeffrey RB, Silverman PM, Federle MP, Chun GH. Computed tomography of omental pathology. J Comput Assist Tomogr 1986; 10: 62-66. https://doi.org/10.1097/00004728-198601000-00013
  3. Diop AD, Fontarensky M, Montoriol PF, Da Ines D. CT Imaging of peritoneal carcinomatosis and its mimic. Diagnostic and Interventional Imaging 2014; 95: 861-872. https://doi.org/10.1016/j.diii.2014.02.009
  4. Ehrhart EJ, Debra A. Kamstock, Barbara E. Powers. The pathology of neoplasia. In: Withrow and MacEwen's Small Animal Clinical Oncology. 5th ed. WB Saunders. 2013: 51-67.
  5. Feldman AL, Dogan A. Diagnostic uses of Pax5 immunohistochemistry. Adv Anat Pathol 2007; 14: 323-334. https://doi.org/10.1097/PAP.0b013e3180ca8a49
  6. Gabor LJ, Canfield PJ, Malik R. Immunophenotypic and histological characterization of 109 cases of feline lymphosarcoma. Aust Vet J 1999; 77: 436-441. https://doi.org/10.1111/j.1751-0813.1999.tb12085.x
  7. Gabor LJ, Malik R, Canfield PJ. Clinical and anatomical features of lymphosarcoma in 118 cats. Aust Vet J 1998; 76: 725-732. https://doi.org/10.1111/j.1751-0813.1998.tb12300.x
  8. Jensen KC, Higgins JP, Montgomery K, Kaygusuz G, van de Rijn M, Natkunam Y. The utility of PAX5 immunohistochemistry in the diagnosis of undifferentiated malignant neoplasms. Mod Pathol 2007; 20: 1-7. https://doi.org/10.1038/modpathol.3800716
  9. Karube K, Ohshima K, Tsuchiya T, Yamaguchi T, Suefuji H, Suzumiya J, Harada M, Kikuchi M. Non-B, non-T neoplasms with lymphoblast morphology: further clarification and classification. Am J Surg Pathol 2003; 27: 1366-1374. https://doi.org/10.1097/00000478-200310000-00009
  10. Kim Y-S, Cho O-K, Song S-Y, Lee H-S, Rhim H-C, Koh B-H. Peritoneal lymphomatosis: CT findings. Abdom Imaging 1998; 23: 87-90. https://doi.org/10.1007/s002619900292
  11. Little L, Patel R, Goldschmidt M. Nasal and nasopharyngeal lymphoma in cats: 50 cases (1989-2005). Vet Pathol 2007; 44: 885-892. https://doi.org/10.1354/vp.44-6-885
  12. Monteiro CB, O'Brien RT. A retrospective study on the sonographic findings of abdominal carcinomatosis in 14 cats. Vet Radiol Ultrasound 2004; 45: 559-564.
  13. Mooney SC, Hayes AA, Matus RE, MacEwen EG. Renal lymphoma in cats: 28 cases (1977-1984). J Am Vet Med Assoc 1987; 191: 1473-1477.
  14. Moore AS, Cotter SM, Frimberger AE, Wood CA, Rand WM, L'Heureux DA. A comparison of doxorubicin and COP for maintenance of remission in cats with lymphoma. J Vet Intern Med 1996; 10: 372-375. https://doi.org/10.1111/j.1939-1676.1996.tb02083.x
  15. Morgan KRS, North CE, Thompson DJ. Sonographic features of peritoneal lymphomatosis in 4 cats. J Vet Intern Med 2018; 32: 1178-1184. https://doi.org/10.1111/jvim.15099
  16. Morvinski DF, Verma IM. Dedifferentiation and reprogramming: origins of cancer stem cells. EMBO rep 2014; 15: 244-253. https://doi.org/10.1002/embr.201338254
  17. Oetelaar GS, Lim CK, Heng HG, Fulkerson CM, Shaevitz MH, Thompson CA. Ultrasonographic features of colonic Bcell lymphoma with mesenteric lymphomatosis in a cat. Vet Radiol Ultrasound 2018 Jul 16; doi: 10.1111/vru.12665.
  18. O'Neill AC, Shinagare AB, Rosenthal MH, Tirumani SH, Jagannathan JP, Ramaiya NH. Differences in CT features of peritoneal carcinomatosis, sarcomatosis, and lymphomatosis: Retrospective analysis of 122 cases at a tertiary cancer institution. Clin Radiol 2014; 69: 1219-1227. https://doi.org/10.1016/j.crad.2014.06.019
  19. Penninck DG, d'Anjou MA. Gastrointestinal tract. Atlas of Small Animal Ultrasonography. 2nd ed. Ames: Wiley Blackwell. 2015: 290.
  20. Penninck DG, Moore AS, Tidwell AS, Matz ME, Freden GO. Ultrasonography of alimentary lymphosarcoma in the cat. Vet Radiol Ultrasound 1994; 35: 299-306.
  21. Pohlman LM, Higginbotham ML, Welles EG, Johnson CM. Immunophenotypic and histologic classification of 50 cases of feline gastrointestinal lymphoma. Vet Pathol 2009; 46: 259-268. https://doi.org/10.1354/vp.07-VP-0122-P-FL
  22. Roccabianca P, Vernau W, Caniatti M, Moore PF. Feline large granular lymphocyte (LGL) lymphoma with secondary leukemia: primary intestinal origin with predominance of a CD3/ CD8(alpha)(alpha) phenotype. Vet Pathol. 2006; 43: 15-28. https://doi.org/10.1354/vp.43-1-15
  23. Sheth S, Horton KM, Garland MR, Fishman EK. Mesenteric neoplasms: CT appearances of primary and secondary tumors and differential diagnosis. Radiographics 2003; 23: 457-473. https://doi.org/10.1148/rg.232025081
  24. Sierra M, Viera R, Ferreira M, Pascoli A, Reis N, Jark P, Hernandez GV, Costa MT, Nardi AD, Calazans S. Cutaneous lymphoma of the tarsus in a cat-case study. Revista MVZ Cordoba 2017; 22: 5747-5754.
  25. Takahashi R, Goto N, Ishii H, Ogiso Y, Saegusa J. Pathological observations of natural cases of feline lymphosarcomatosis. Nippon Juigaku Zasshi 1974; 36: 163-173.
  26. Taylor SS, Goodfellow MR, Browne WJ, Walding B, Murphy S, Tzannes S, Gerou-Ferriani M, Schwartz A, Dobson JM. Feline extranodal lymphoma: response to chemotherapy and survival in 110 cats. J Small Anim Pract 2009; 50: 584-592. https://doi.org/10.1111/j.1748-5827.2009.00813.x
  27. Vail DM. Feline lymphoma and leukemia. In: Withrow SJ, Vail DM, Page RL, eds. Small Animal Clinical Oncology. Missouri, USA: Elsevier Saunders. 2013: 638-653.
  28. Vail DM, Moore AS, Ogilvie GK, Volk LM. Feline lymphoma (145 cases): Proliferation indices, CD3 immunoreactivity and their association with prognosis in 90 cats receiving therapy. J Vet Intern Med 1998; 12: 349-354. https://doi.org/10.1111/j.1939-1676.1998.tb02134.x
  29. Visvader JE, Lindeman GJ. Cancer stem cells: current status and evolving complexities. Cell Stem Cell 2012; 10: 717-728. https://doi.org/10.1016/j.stem.2012.05.007
  30. Whitman JJ, Cockrell KO, Hall WT, Gilmore CE. An unusual case of feline leukemia and an associated syncytium-forming virus. Am J Vet Res 1975; 36: 873-880.