CELLMED (셀메드)

Cellmed Orthocellular Medicine and Pharmaceutical Association (셀메드 세포교정의약학회)
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A Randomized Active Controlled Clinical Trial to Evaluate Safety and Efficacy of a Topical Unani Formulation Marham Kharish Jadeed in the Management of Qūbā (Tinea Corporis)

  • Aaliya, Aaliya (Department of Moalajat, National Research Institute of Unani Medicine for Skin Disorders) ;
  • Nawab, Mohammad (Department of Moalajat, National Research Institute of Unani Medicine for Skin Disorders) ;
  • Kazmi, M.H. (Department of Moalajat, National Research Institute of Unani Medicine for Skin Disorders) ;
  • Ayyub, Sana (Department of Moalajat, National Research Institute of Unani Medicine for Skin Disorders)
  • Received : 2020.06.06
  • Accepted : 2020.06.23
  • Published : 2020.08.31
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Abstract

Introduction: Qūbā (Tinea Corporis) is a very common disease widely prevalent worldwide. 20 - 25 % individuals suffer for this stubborn disease. Unani System of Medicine offers its treatment. There are many pharmacopoeial formulations indicated for various types of dermatophytic infections. In this study clinical efficacy and safety of the topical Unani formulation Marham Kharish Jadeed (a compound drug in the dosage form of an ointment) was assessed and compared with a standard conventional medicine. Materials and methods: A clinical study was conducted on 60 participants of qūbā randomized into test and control groups (n=30 in each group). The participants were clinically diagnosed and confirmed by microscopy of skin scrapings. The efficacy of the Unani formulation was assessed in terms of TSS score and elimination of fungal elements from the skin lesions. The data collected were analyzed statistically. Results and discussion: The study showed that the Unani formulation had comparatively better efficacy clinically than conventional medicine Terbinafine hydrochloride 1% cream in terms of reduction of itching, erythema, scaling, peripheral raised margins of the lesion comparing to baseline. In this study, 27 participants in test group and 18 participants in control group were completely cured (≥75% reduction in TSS Score with Mycological Cure) after 4 weeks of treatment. The efficacy of the Unani formulation was found significant statistically. The individual drugs of the formulations having analgesic (Musakkin), blood purifier (Muṣaffi-i-Dam), demulcent (Mulaṭṭif), antifungal (Qātil-i-fafūndῑ), detergent (Jālῑ), refrigerant (Mubarrid) and antiseptic (Dāfi'-i-'Ufūnat) properties might be responsible for the efficacy of Unani formulation. Conclusion: The findings of the study suggested that the Unani formulation was found effective and safe in the management of qūbā. No local and systemic adverse effect was reported during the study.

Keywords

References

  1. Anonymous. National Formulary of Unani Medicine, Vol - 5. 1st ed., (New Delhi, India; Central Council for Research in Unani Medicine), pp. 115-117, 2008.
  2. Anonymous. Qarabadeen Majeedi, (New Delhi, India; All India Unani Tibbi Conference), 1986
  3. Afzal M, Wang Z, Song Z, & Cox R. Preliminary phytochemical screening and antimicrobial activities of various fractions of Mallotus philippensis Muell. Journal of Medicinal Plants Research, 2013;7(41);3066-3070.
  4. Banerjee M, Basak S, Gangopadhyay D, Ghosh A, & Das K. Comparative evaluation of effectivity and safety of topical amorolfine and clotrimazole in the treatment of tinea corporis. Indian Journal of Dermatology, 2011;56(6);657. https://doi.org/10.4103/0019-5154.91823
  5. Bhatia VK & Sharma PC. Epidemiological studies on dermatophytosis in human patients in Himachal Pradesh, India. SpringerPlus, 2014;3(1); 1-7. https://doi.org/10.1186/2193-1801-3-1
  6. Fratini F, Cilia G, Turchi B & Felicioli A. Beeswax: A minireview of its antimicrobial activity and its application in medicine. Asian Pacific Journal of Tropical Medicine, 2016;9(9);839-843. https://doi.org/10.1016/j.apjtm.2016.07.003
  7. Ghani HN. Khazainul Advia, (New Delhi, India; Idara Kitab-UL- Shifa), pp. 1276-7, YNM
  8. Hakim HMA. Bustan ul Mufridaat, (New Delhi, India; Idara Kitab-UL- Shifa), pp. 339, 441-2, 2002.
  9. Jameson JL, Fauci AS, Kasper DL, Hauser SL, Longo DL, Loscalzo J. Harrison's Principles of Internal Medicine Vol - 2. 19th ed.(McGraw Hill), 2015.
  10. Jerajani H, Janaki C, Kumar S & Phiske M. Comparative assessment of the efficacy and safety of sertaconazole (2%) cream versus terbinafine cream (1%) versus luliconazole (1%) cream in patients with dermatophytoses: A pilot study. Indian Journal of Dermatology, 2013; 58(1); 34. https://doi.org/10.4103/0019-5154.105284
  11. Jerajani HR, Amladi ST, Bongale R, Adepu V, Tendolkar UM, Sentamilselvi G, Cooverji ND. Evaluation of clinical efficacy and safety of once daily topical administration of 1% oxiconazole cream and lotion in dermatophytosis : an open label, non-comparative multicentre study. Indian Journal of Dermatology, Venereology and Leprology, 2000; 66(4);188-18892.
  12. Kabiruddin, H. Mukhzinul Mufridaat, (New Delhi, India; Faisal Brothers, Daryaganj), pp. 346-47, YNM
  13. Lakshmi CPV, Bengalorkar GM & Shiva Kumar V. Clinical Efficacy of Topical Terbinafine Versus Topical Luliconazole in Treatment of Tinea Corporis/Tinea Cruris Patients. In British Journal of Pharmaceutical Research (Vol. 3), 2013.
  14. Nadkarni AK. Indian Materia Medica, Vol - Two. 3rd ed. (Mumbai, India; Popular Prakashan Private Limited), pp. 86, 96-97, 119-123, 132-133,151-152, 2010.
  15. Poluri LV, Indugula JP & Kondapaneni SL. Clinicomycological Study of Dermatophytosis in South India. Journal of Laboratory Physicians, 2015;7(02);084-089. https://doi.org/10.4103/0974-2727.163135
  16. Singh P & Nanda A. Antimicrobial and antifungal potential of zinc oxide nanoparticles in comparison to conventional zinc oxide particles. Journal of Chemical and Pharmaceutical Research, 2013;5(11); 457-463.
  17. Suleiman EA& Mohamed EA. In Vitro Activity of Lawsonia inermis (Henna) on Some Pathogenic Fungi, Journal of Mycology, 2014.
  18. Sumyuktha J, Narasimhan M & Ahamed PB. A comparative trial between the therapeutic efficacy of topical 2% sertaconazole cream and 1% terbinafine cream in the treatment of tinea cruris/tinea corporis. International Journal of Research in Dermatology, 2017; 3(1); 59. https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20170082
  19. Tripathi KD. Essentials of Medical Pharmacology. 7th ed. (New Delhi, India; Jaypee Brothers Medical Publishers (P) Ltd) pp. 795-796, 2015.