DOI QR코드

DOI QR Code

Active components delivery rate from acrylic resin maxillary surgical obturator: Part I

  • Al-Kaabi, Arshad (Department of Dental Technology, College of Health and Medical Technology, Middle Technical University) ;
  • Hamid, Mohammed A. (Department of Dental Technology, College of Health and Medical Technology, Middle Technical University)
  • 투고 : 2020.02.07
  • 심사 : 2020.04.26
  • 발행 : 2020.06.25

초록

The purpose of this study was to observe the trend of compounds release from acrylic resin oral prosthesis when used for drug delivery as well as a restoration. In this study, 10 specimens of heat-cured polymethylmethacrylate material were prepared and loaded with methylene blue biological stain. The specimens were then submerged in vials with 5 ml distilled water for 24 hours. The extraction procedure continued for 4 days, each day the specimens were immersed in another 5 ml distilled water vial. All extracted solutions were analyzed by visible light spectroscopy for absorbance comparison. The statistical results showed that the absorbance values were significantly different in the first day of extraction than the following days. However, there was no statistical difference among the 2nd, 3rd and 4th days of extraction. Biological stain loading to acrylic resin at the mixing stage, and then after extraction in distilled water, showed a burst release during the first day followed by a constant release during the following few days.

키워드

참고문헌

  1. Ajay, R., Suma, K. and Ali, S.A. (2019), "Monomer modifications of denture base acrylic resin: A systematic review and meta-analysis", J. Pharm. Bioallied. Sci., 11(Suppl 2), S112-S125. https://doi.org/10.4103/JPBS.JPBS_34_19
  2. Al Thaher, Y., Yang, L., Jones, S.A., Perni, S. and Prokopovich, P. (2018), "LbL-assembled gentamicin delivery system for PMMA bone cements to prolong antimicrobial activity", PLoS One, 13(12), e0207753. https://doi.org/10.1371/journal.pone.0207753
  3. Al-Kheraif, A.A.A. (2014), "The effect of mechanical and chemical polishing techniques on the surface roughness of heat-polymerized and visible light-polymerized acrylic denture base resins", Saudi Dent. J., 26(2), 56-62. https://doi.org/10.1016/j.sdentj.2013.12.007
  4. Anagnostakos, K. (2017), "Therapeutic use of antibiotic-loaded bone cement in the treatment of hip and knee joint infections", J. Bone Joint Infection, 2(1), 29-37. https://doi.org/10.7150/jbji.16067
  5. Bettencourt, A.F., Feliz, M., Sousa, C., Goncalves, L. and Neves, C.B. (2016), "An acrylic reline resin loaded with chlorhexidine: Insights on drug release", Revista Portuguesa de Estomatologia, Medicina Dentaria e Cirurgia Maxilofacial, 57(3), 125-131. https://doi.org/10.1016/j.rpemd.2016.04.001
  6. Chalian, V.A., Drane, J.B. and Standish, S.M. (1972), Maxillofacial Prosthetics: Multidisciplinary Practice, The Williams & Wilkins, Baltimore, MD, USA.
  7. Gandhi, A., Paul, A., Sen, S.O. and Sen, K.K. (2015), "Studies on thermoresponsive polymers: Phase behaviour, drug delivery and biomedical applications", Asian J. Pharmaceut. Sci., 10(2), 99-107. https://doi.org/10.1016/j.ajps.2014.08.010
  8. Haseeb, A., Ajit Singh, V., Teh, C.S.J. and Loke, M.F. (2019), "Addition of ceftaroline fosamil or vancomycin to PMMA: An in vitro comparison of biomechanical properties and anti-MRSA efficacy", J. Orthop. Surg., 27(2). https://doi.org/10.1177/2309499019850324
  9. Kar, S. and Tripathi, A. (2016), "Treatment outcome with delayed maxillary obturator prosthesis: case series of four patients", J. Prosthodont, 25(2), 174-177. https://doi.org/10.1111/jopr.12275
  10. Kati, F.A. and Al-Kaabi, A.F.J. (2016), "Effect of oil paint addition on micro hardness of acrylic ocular prosthesis", Iraqi Dent. J., 38(2), 87-89. http://dx.doi.org/10.26477/idj.v38i2.83
  11. Letchmanan, K., Shen, S.C., Ng, W.K., Kingshuk, P., Shi, Z., Wang, W. and Tan, R.B. (2017), "Mechanical properties and antibiotic release characteristics of poly(methyl methacrylate)-based bone cement formulated with mesoporous silica nanoparticles", J. Mech. Behavior Biomed. Mater., 72, 163-170. https://doi.org/10.1016/j.jmbbm.2017.05.003
  12. Li, J., Chen, X., Qi, M. and Li, Y. (2018), "Sentinel lymph node biopsy mapped with methylene blue dye alone in patients with breast cancer: A systematic review and meta-analysis", PLoS One, 13(9), e0204364. https://doi.org/10.1371/journal.pone.0204364
  13. Minsley, G.E., Warren, D.W. and Hinton, V. (1987), "Physiologic responses to maxillary resection and subsequent obturation", J. Prosthet. Dent., 57, 338-344. https://doi.org/10.1016/0022-3913(87)90309-X
  14. PubChem (2020), Methylene Blue. [online] Available at: [Accessed 11 April 2020]
  15. Qazi, T.H., Mooney, D.J., Pumberger, M., Geissler, S. and Duda, G.N. (2015), "Biomaterials based strategies for skeletal muscle tissue engineering: Existing technologies and future trends", Biomaterials, 53, 502-521. https://doi.org/10.1016/j.biomaterials.2015.02.110
  16. Shanks, D. (2012), "Control and Elimination Of Plasmodium Vivax", Chapter 6 - In: Advances in Parasitology, (80th Ed.), Academic Press, pp. 301-341.
  17. Tasopoulos, T., Chatziemmanouil, D., Karaiskou, G., Kouveliotis, G., Wang, J. and Zoidis, P. (2019), "Fabrication of a 3D-printed interim obturator prosthesis: A contemporary approach", J. Prosthet. Dent., 121(6), 960-963. https://doi.org/10.1016/j.prosdent.2018.10.004