대한한방부인과학회지 (The Journal of Korean Obstetrics and Gynecology)

  • 제33권3호
  • /
  • Pages.149-174
  • /
  • 2020
  • /
  • 1229-4292(pISSN)
  • /
  • 2508-3619(eISSN)
대한한방부인과학회 (The Society of Korean Medicine Obstetrics and Gynecology)
권호 표지
DOI QR코드

DOI QR Code

온경탕이 족부냉증에 미치는 영향에 대한 다기관 이중맹검 무작위 대조군 연구

Effect of Onkyung-tang on Cold Hypersensitivity on Feet: A Multi-center Double-blind Randomized Controlled Trial

  • 권나연 (세명대학교 한의과대학 한방부인과 교실) ;
  • 유준상 (상지대학교 한의과대학 사상체질의학교실) ;
  • 김형준 (세명대학교 한의과대학 한방부인과 교실) ;
  • 이동녕 (세명대학교 한의과대학 한방부인과 교실)
  • Kwon, Na-Yoen (Dept. of Korean Obstetrics and Gynecology, College of Korean Medicine, Se-Myung University) ;
  • Yoo, Joon-Sang (Dept. of Sasang Constitutional Medicine, College of Korean Medicine, Sang-Ji University) ;
  • Kim, Hyeong-Jun (Dept. of Korean Obstetrics and Gynecology, College of Korean Medicine, Se-Myung University) ;
  • Lee, Dong Nyung (Dept. of Korean Obstetrics and Gynecology, College of Korean Medicine, Se-Myung University)
  • 투고 : 2020.07.18
  • 심사 : 2020.08.28
  • 발행 : 2020.08.28
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objectives: This study was aimed to figure out the effect of Onkyung-tang (OKT) on cold hypersensitivity on feet in female patients. Methods: This study was designed to implement multi-center randomized clinical trial in three korean medical hospitals. The female patients who were enrolled in this study were 112 women who suffered from cold hypersensitivity on feet. They were randomly allocated into OKT group or control group in 1:1 ratio. The primary outcome was change in score of visual analogue scale of hypersensitivity on feet, and the secondary outcomes were thermometer of LU4, PC8, ST32, LR3, visual analogue scale of hypersensitivity on hands, result of cold stress test, and score of World Health Organization Quality of Life-BREF. Results: In both group, the VAS of hypersensitivity on feet and hands was decreased while taking the medicine, and the effect of decreasing the VAS continues for the 4 weeks after the end of medication (p<0.001, 0.003, 0.001). In OKT group, the body temperature difference in lower extremity (ST32-LR3) was steadily decreased at every visit and it was statistically significant(p=0.003, <0.001). On the other hand, in control group, the body temperature difference in lower extremity was decreased only while taking the medicine (p<0.001). Conclusions: OKT significantly reduced discomfort coldness on feet in patients, and the effect of treatment was maintained at least for four weeks after medication.

키워드

참고문헌

  1. Jang JB, Lee KS, Song BK. Study on the Definition of the Female's Part-Coldness Syndrome. Journal of Korean Medicine. 1994;15(2):397-411.
  2. Ko SW, et al. Diagnostic Tool for Cold Sensation of Hands; A Preliminary Study. J Int Korean Med. 2015;36(3):228-35.
  3. Lee DN, et al. A Survey on Korean Medicine Doctors' Recognition and Treatment for Developing Korean Medicine Clinical Practice Guideline of Coldness of Hands and Feet. J Korean Obstet Gynecol. 2017;30(3):92-116. https://doi.org/10.15204/jkobgy.2017.30.3.092
  4. Kim CM. Diagnosis and treatment of cold hands/feet syndrome. Korean Journal of Family Medicine. 2004;25(11):273-7.
  5. Choi WS, et al. The Prevalence of Raynaud's Disease among the Complaints of Abnormal Sensation on Hands and Feet. J Korean Acad Fam Med. 2003;24(12):1085-91.
  6. Lee SR, et al. Shanghanlun. 1st rev. ed. Seoul:Kyunghee university publishing Co. 1996:568, 608.
  7. Kwon NY, Lee DN. A Study on Menstrual Pattern of Patients with Cold Hypersensitivity on Hands and Feet. J Korean Obstet Gynecol. 2019;32(3):174-91. https://doi.org/10.15204/JKOBGY.2019.32.3.174
  8. Kwon JY, et al. A Study of Clinical Characteristics of Female Patients with Cold Hypersensitivity on Hands and Feet. J Korean Med. 2018;39(2):64-79. https://doi.org/10.13048/jkm.18016
  9. Park YK, et al. Study on Heart Rate Variability Characteristics of Cold Hypersensitivity of Hands and Feet Patients. J Korean Obstet Gynecol. 2015;28(1):92-101. https://doi.org/10.15204/jkobgy.2015.28.1.092
  10. Kim DH, et al. Standardization of Diagnosis of Cold Hypersensitivity of Hands and Feet by D.I.T.I. J Korean Obstet Gynecol. 2001;14(2):129-34.
  11. Kim JW, et al. Analysis of Factors that Can Affect the Assessment of Severity of Cold Hypersensitivity in Hands and Feet. J Korean Obstet Gynecol. 2012;25(4):38-45. https://doi.org/10.15204/JKOBGY.2012.25.4.038
  12. Sun SH, et al. A Delphi Study for Treatment Standardization of Coldness in Hands and Feet. Journal of Society of Preventive Korean Medicine. 2015;19(3):131-40.
  13. Park KS, et al. Efficacy and safety of Korean red ginseng for cold hypersensitivity in the hands and feet : A randomized, double-blind, placebo-controlled trial. Journal of Ethnopharmacology. 2014;158(Part A):25-32. https://doi.org/10.1016/j.jep.2014.09.028
  14. Harper A, et al. Development of the World Health Organization WHOQOL-BREF quality of life assessment. Psycol Med. 1998;28(3):551-8. https://doi.org/10.1017/S0033291798006667
  15. The Society of Korean Medicine Obstetrics and Gynecology. Korean Medicine Obstetrics & Gynecology Ha. 3rd rev. ed. Seoul:Euiseongdang Publishing Co. 2012:888.
  16. The Society of Korean Medicine Obstetrics and Gynecology. JinRyoPyeonRam (Manual of Korean Gynecology). 2nd rev. ed. Seoul:Euiseongdang Publishing Co. 2017:304.
  17. Heo J. Dongeuibogam. 4th rev. ed. Hadong :Dongeuibogam publishing Co. 2010: 1751.
  18. Hwang DY. Bangyackhappyun. 2nd rev. ed. Seoul:Yeongnim Publishing Co. 2011:171-2.
  19. Lee YT, Oh SS. Study on Indications for the Use of Onkyung-tang in Hyungsang Medicine. Korean J Oriental Physiology & Pathology. 2005;19(2):339-46.
  20. Kim KJ, Kim KJ. A Case about the Effect of Onkyung-tang on Acne. Collection of dissertations of Kyung won graduate school. 2010.
  21. Kwon CN, Lee IS. The Effect of Onkyung-tang on Uterine Changes of Ovariectomized Rats. J Korean Obstet Gynecol. 2001;14(2):56-68.