The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology (한방안이비인후피부과학회지)

The Society of Korean Medicine Ophthalmology, Otolaryngology & Dermatology (대한한방안이비인후피부과학회)
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Evaluate efficacy of fermented soybean(Bio-Peptone)cream in pruritus : Randomized, double-blinded, placebo-controlled, parallel-group clinical experiment study

피부 가려움증에 대한 대두(大豆) 발효물(Bio-Peptone)크림의 유효성 평가 : 무작위 배정, 양측 눈가림, 위약크림 대조, 평행 설계 연구

  • An, Jae-Hyun (Department of Korean Medicine Ophthalmology & Otolaryngology & Dermatology, College of Korean Medicine, Daejeon University) ;
  • Jung, Hyun-A (Department of Korean Medicine Ophthalmology & Otolaryngology & Dermatology, College of Korean Medicine, Daejeon University) ;
  • Kim, Eun-Ju (The Graduate School of Alternative Medicine, Kyonggi University) ;
  • Kim, Ae-Jung (The Graduate School of Alternative Medicine, Kyonggi University)
  • 안재현 (대전대학교 한의과대학 한방안이비인후피부과교실) ;
  • 정현아 (대전대학교 한의과대학 한방안이비인후피부과교실) ;
  • 김은주 (경기대학교 일반대학원 대체의학 교실) ;
  • 김애정 (경기대학교 일반대학원 대체의학 교실)
  • Received : 2020.06.08
  • Accepted : 2020.07.26
  • Published : 2020.08.25
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Abstract

Objectives : The authors conducted randomized, Double-blinded, and placebo-controlled parallel-group clinical experiment study to evaluate efficacy of fermented soybean(Bio-Peptone)cream in pruritus. Methods : The research had been conducted for 4 months from the date of IRB approval(May 26 in 2017) to Sept 2017. The experiment started by randomly distributing 25 subjects with pruritus into experimental group and control group, respectively. The experimental group applied fermented soybean(Bio-Peptone)cream twice a day, in the morning and evening, for one week on itchy area. The effect of the product was evaluated by comparing the PSS(Patient subjective score), moisture level by measuring skin moisture content(Corneometer) and transepidermal water loss(Tewameter), and the Korean version of Skindex-29(index of quality of life improvement) before applying the cream, after applying the cream for one week and after stop applying the cream for one week. The control group conducted identical experiment with the experimental group, except the control group applied placebo instead of the fermented soybean(Bio-Peptone)cream. Results : Pruritus, criterion of the first validation testing, indicates fermented soybean(Bio-Peptone)cream tend to reduce pruritus compare to placebo, although the result is not statistically noticeable. Significant difference in reduction of prutitus, the second validation test was not discovered in both groups. Corneometer and life quality tend to be improved with soy cream than placebo, but not statistically effective and both groups did not show any difference in terms of Tewameter measurement. Conclusions : The result of clinical experiment didn't prove that the fermented soybean(Bio-Peptone)cream is more effective in reducing pruritus than placebo, statistically. The clinical use of soybean product for pruritus requires further studies to be verified.

Keywords

References

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