Journal of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회지)

Korean Society of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회)
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Novel mild fluorination method using light

  • Tien Tan Bui (Department of Nuclear Medicine, Molecular Imaging & Therapeutic Medicine Research Center, Jeonbuk National University Medical School and Hospital) ;
  • Hee-Kwon Kim (Department of Nuclear Medicine, Molecular Imaging & Therapeutic Medicine Research Center, Jeonbuk National University Medical School and Hospital)
  • Received : 2020.12.15
  • Accepted : 2020.12.29
  • Published : 2020.12.31
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Abstract

Fluorine compounds have attracted interest of scientists for immense applications in medicinal chemistry and pharmaceuticals. Recently, photoredox catalysts, both organic-based and metal-based compounds, have been employed in organic synthetic methodology to achieve desirable products due to facile operation and mild reaction condition. Various protocols to prepare fluorination adducts in the presence of photoredox catalysts have been developed from several starting materials with formation of radical scaffolds. In this review, we describe recent advances in the fluorination using light.

Keywords

Acknowledgement

This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2018R1D1A1B07047572).

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