A Case Study of Type 2 Diabetes Patient Using Yeoldahansotang-gami

열다한소탕가미를 활용한 2형 당뇨 환자 치험례

  • Kim, Se-won (Dept. of Clinical Korean medicine, Cardiology and Neurology, Graduate school, Kyung-Hee University) ;
  • Ha, Won Jung (Dept. of Clinical Korean medicine, Cardiology and Neurology, Graduate school, Kyung-Hee University) ;
  • Park, Hojung (Dept. of Clinical Korean medicine, Cardiology and Neurology, Graduate school, Kyung-Hee University) ;
  • Cho, Ki-ho (Dept. of Clinical Korean medicine, Cardiology and Neurology, Graduate school, Kyung-Hee University) ;
  • Mun, Sang-Kwan (Dept. of Clinical Korean medicine, Cardiology and Neurology, Graduate school, Kyung-Hee University) ;
  • Kwon, Seungwon (Dept. of Clinical Korean medicine, Cardiology and Neurology, Graduate school, Kyung-Hee University) ;
  • Jin, Chul (Dept. of Clinical Korean medicine, Cardiology and Neurology, Graduate school, Kyung-Hee University) ;
  • Jung, Woo-sang (Dept. of Clinical Korean medicine, Cardiology and Neurology, Graduate school, Kyung-Hee University)
  • 김세원 (경희대학교 대학원 한방순환신경내과학교실) ;
  • 하원정 (경희대학교 대학원 한방순환신경내과학교실) ;
  • 박호정 (경희대학교 대학원 한방순환신경내과학교실) ;
  • 조기호 (경희대학교 대학원 한방순환신경내과학교실) ;
  • 문상관 (경희대학교 대학원 한방순환신경내과학교실) ;
  • 권승원 (경희대학교 대학원 한방순환신경내과학교실) ;
  • 진철 (경희대학교 대학원 한방순환신경내과학교실) ;
  • 정우상 (경희대학교 대학원 한방순환신경내과학교실)
  • Published : 2020.12.01

Abstract

■ Objectives The purpose of this study is to report on a case that showed improvement in type 2 diabetic patients by using herbal medicine, Yeoldahansotang-gami. ■ Methods Yeoldahansotang-gami was given to patients with type 2 diabetes for 71days. To evaluate the effect, blood glucose was measured 4 times a day. As measured blood sugar, the frequency of hyperglycemia, changes in fasting blood sugar, changes in postprandial blood sugar, and changes in glucose variability were analyzed. The patient's insulin injection dose change was observed, and HbA1c and glycated albumin were measured. Follow-up was performed for 7 months to observe whether the treatment effect was maintained. ■ Results During treatment, the patient's blood sugar control, glucose variability, and HbA1c were improved, and insulin injection dose was gradually reduced and stopped. HbA1c and glycated albumin levels maintained improvement without insulin injection during the follow-up period. ■ Conclusion This study showed the effect of yeoldahansotang-gami on type 2 diabetes patient.

Keywords

References

  1. World Health Organization. Global report on diabetes. Geneva. 2016. pp. 11-15
  2. Korea Centers for Disease Control and Prevention. Korea Health Statistics 2016: Korea National Health and Nutrition Examination Survey (KNHANES VII-1). Osong: Korea Centers for Disease Control and Prevention.
  3. International Diabetes Federation. (2019). IDF diabetes atlas: 9th edition 2019. Brussels: International Diabetes Federation. pp. 80-81
  4. Meece J. Dispelling Myths and removing barriers about insulin in type 2 diabetes. Diabetes Educ. 2006;32(1S):9S-18S https://doi.org/10.1177/0145721705285638
  5. 황지호, 장은수, 유종향 등. 열다한소탕과 청폐사간탕의 활용에 대한 임상적 연구. 한국한의학연구원. 2008; 2008;14(2):101-106
  6. 배정환. 청폐사간탕이 비만유도 흰쥐의 체중, 혈액 및 UCP2 발현에 미치는 영향. 경희대학교. 2002
  7. 구진숙, 김장현. 청폐사간탕이 streptozotocin으로 유발된 흰쥐의 실험적 당뇨에 미치는 영향. 대한한방소아과학회지. 1997;11(1):227-247
  8. Ka Wu, Tao Liang, Xiaoqun Duan 등. Anti-diabetic effects of puerarin, isolated from Pueraria lobata (Willd.), on streptozotocin-diabetogenic mice through promoting insulin expression and ameliorating metabolic function. Food and Chemical Toxicology. 2013;60:341-347 https://doi.org/10.1016/j.fct.2013.07.077
  9. Lei Yang, Dongdong Yao, Haiyuan Yang 등. Puerarin Protects Pancreatic β-Cells in Obese Diabetic Mice via Activation of GLP-1R Signaling. Mol Endocrinol. 2016; 30(3):361-371 https://doi.org/10.1210/me.2015-1213
  10. Huan-ting Li, Xiao-dong Wu, K. Davey 등. Antihyperglycemic Effects of Baicalin on Streptozotocin - Nicotinamide induced Diabetic Rats. Phytotherapy Research. 2010;25(2):189-194 https://doi.org/10.1002/ptr.3238
  11. Bu-Yeo Kim, Kwang Hoon Song, Chi-Yeon Lim 등. Therapeutic properties of Scutellaria baicalensis in db/db mice evaluated using Connectivity Map and network pharmacology. Sci Rep. 2017;31(7):41711
  12. Ahmed OM, Abdel-Reheim ES, Ashour MB 등. Efficacies of Eruca Sativa and Raphanus Sativus Seeds' Oils in StreptozotocinInduced Diabetic Rats. Int J Clin Endocrinol Metab. 2016;2(1): 34-43 https://doi.org/10.17352/ijcem.000020
  13. Kyoung-Sook Kim, En-Kyung Seo, YoungChoon Lee 등. Effect of dietary Platycodon grandiflorum on the improvement of insulin resistance in obese Zucker rats. The Journal of Nutritional Biochemistry. 2000 ;11(9):420-424 https://doi.org/10.1016/S0955-2863(00)00098-X
  14. Eun-Young Park, Eung-Hwi Kim, Chul-Young Kim 등. Angelica dahurica Extracts Improve Glucose Tolerance through the Activation of GPR119. PLoS One. 2016;11(7):e0158796 https://doi.org/10.1371/journal.pone.0158796
  15. Hyo Sang Han, Hyelin Jeon, Se Chan Kang. Phellopterin isolated from Angelica dahurica reduces blood glucose level in diabetic mice. Heliyon. 2018;4(3):e00577 https://doi.org/10.1016/j.heliyon.2018.e00577
  16. 서성환, 김재현. 혈당 변동성. Journal of Korean Diabetes. 2014;15(4):196-201 https://doi.org/10.4093/jkd.2014.15.4.196
  17. 이상아, 박중열. 인슐린 투여가 당뇨병 환자의 삶의 질, 우울 요소에 미치는 영향. 대한내과학회지. 2009;77(1):57-59
  18. Christopher S Gray, Anthony J Hildreth, George K M M Alberti 등. Poststroke hyperglycemia: natural history and immediate management. Stroke. 2004; 35(1):122-126. https://doi.org/10.1161/01.str.0000106916.81680.c0
  19. Sharan Badiger. Prema T. Akkasaligar. Utkarsha Narone. Hyperglycemia and Stroke. International Journal of Stroke Research. 2013;1(1):1-6