Journal of Korean Traditional Oncology (대한암한의학회지)

Korean Association of Traditional Oncology (대한암한의학회)
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Effectiveness of acupuncture as an adjunctive therapy for lung cancer: A systematic review and meta-analysis

  • Shen, Lei (Department of Sasang Constitutional Medicine, College of Korean Medicine, Wonkwang University) ;
  • Gwak, Si Ra (Department of Sasang Constitutional Medicine, College of Korean Medicine, Wonkwang University) ;
  • Joo, Jong Cheon (Department of Sasang Constitutional Medicine, College of Korean Medicine, Wonkwang University) ;
  • Park, Soo Jung (Department of Sasang Constitutional Medicine, College of Korean Medicine, Woosuk University)
  • Received : 2020.06.15
  • Accepted : 2020.06.26
  • Published : 2020.06.30
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Abstract

Objectives : Lung cancer is one of the most common cancer and the leading cause of cancer deaths worldwide. This study aimed to evaluate the role of acupuncture as an adjunctive therapy for lung cancer. Methods : We conducted a systematic review and meta-analysis on the role of acupuncture therapy in lung cancer treatment by electronic and manual searching in ninedatabases, including PubMed, Cochrane library, Embase, Korean databases, and Chinese medical databases. Results : A total of 21 trials were included in the meta-analysis. The study results showed that acupuncture therapy had significant efficacy in immuneregulation, including CD3 andCD4. Further analysis revealed that acupuncture therapy significant improvements in quality of life, including Karnofsky performance status(KPS)score, functional assessment of cancer therapy-lung cancer subscale (FACT-L) and European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30). In addition, the pooled studies also showed that acupuncture therapy reduced cancer pain and chemotherapy-induced nausea and vomiting. Conclusions : Our study provides moderate evidence of the efficacy of the acupuncture therapy in the treatment of lung cancer.

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References

  1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018, 68(6):394-424. https://doi.org/10.3322/caac.21492
  2. Birring SS, Peake MD: Symptoms and the early diagnosis of lung cancer. Thorax 2005, 60(4):268-269. https://doi.org/10.1136/thx.2004.032698
  3. Nasim F, Sabath BF, Eapen GA: Lung Cancer. Med Clin North Am 2019, 103(3):463-473. https://doi.org/10.1016/j.mcna.2018.12.006
  4. The Korea Central Cancer Registry. Cancer Registration& statistics. Available from http://kosis.kr/statHtml/statHtml.do?orgId=117&tblId=DT_117N_A00021&conn_path=I2.
  5. Hoy H, Lynch T, Beck M: Surgical Treatment of Lung Cancer. Crit Care Nurs Clin North Am 2019, 31(3):303-313. https://doi.org/10.1016/j.cnc.2019.05.002
  6. Brunelli A, Charloux A, Bolliger CT, Rocco G, Sculier JP, Varela G, Licker M, Ferguson MK, Faivre-Finn C, Huber RM et al: ERS/ESTS clinical guidelines on fitness for radical therapy in lung cancer patients (surgery and chemo-radiotherapy). Eur Respir J 2009, 34(1):17-41. https://doi.org/10.1183/09031936.00184308
  7. Bahl A, Sharma DN, Julka PK, Rath GK: Chemotherapy related toxicity in locally advanced non-small cell lung cancer. J Cancer Res Ther 2006, 2(1):14-16. https://doi.org/10.4103/0973-1482.19767
  8. Nurgali K, Jagoe RT, Abalo R: Editorial: Adverse Effects of Cancer Chemotherapy: Anything New to Improve Tolerance and Reduce Sequelae? Front Pharmacol 2018, 9:245. https://doi.org/10.3389/fphar.2018.00245
  9. Greenlee H, DuPont-Reyes MJ, Balneaves LG, Carlson LE, Cohen MR, Deng G, Johnson JA, Mumber M, Seely D, Zick SM et al: Clinical practice guidelines on the evidence-based use of integrative therapies during and after breast cancer treatment. CA Cancer J Clin 2017, 67(3):194-232. https://doi.org/10.3322/caac.21397
  10. Tao WW, Jiang H, Tao XM, Jiang P, Sha LY, Sun XC: Effects of Acupuncture, Tuina, Tai Chi, Qigong, and Traditional Chinese Medicine Five-Element Music Therapy on Symptom Management and Quality of Life for Cancer Patients: A Meta-Analysis. J Pain Symptom Manage 2016, 51(4):728-747. https://doi.org/10.1016/j.jpainsymman.2015.11.027
  11. Chen JB: The effect for nausea and vomiting of acupuncture to patients with lung cancer after the first time chemotherapy. Guangzhou University of Chinese Medicine; 2016.
  12. Cheng CS, Chen LY, Ning ZY, Zhang CY, Chen H, Chen Z, Zhu XY, Xie J: Acupuncture for cancer-related fatigue in lung cancer patients: a randomized, double blind, placebo-controlled pilot trial. Supportive care in cancer 2017, 25(12):3807-3814. https://doi.org/10.1007/s00520-017-3812-7
  13. Guo JY: Wrist ankle acupuncture treatment of non-small cell lung cancer with cisplatin clinical observation of chemotherapy regimens to vomit. Xinjiang Medical University; 2017.
  14. Li SC, Ying Z, Li ZL, Guo HL, Hao WY: influence of fire needle stimulation at SiHua acupoints on IL-6, TNF-a in the patients with advanced non-small cell lung cancer after chemotherapy [火針四花穴對晚期非小細胞肺癌化療患者IL-6. TNF-${\alpha}$ 的影響]. Journal of New Chinese Medicine 2014, 46(5):170-173.
  15. Li DH, Yu J, Li R, Sun X, Wang AH: Effect of warming acupuncture and moxibustion on digestive tract reaction and immune function in patients with advanced non-small cell lung cancer. Medical Innovation of China 2020, 17(04):142-146.
  16. Lin GH, Li LX, Lin LZ, Chen CY, Li QL, Guo YQ, Zhang YF: Clinical observation on the prevention and treatment of toxic and side effects of chemotherapy for lung cancer by electroacupuncture at BL17 [電針膈俞穴防治肺癌化療毒副反應臨床觀察]. In: Proceedings of the 11th Symposium of Guangdong Provincial Association of Acupuncture and Moxibustion [广東省針灸學會第十一次學術硏討會論文集]; 广州. 2010: 301-304.
  17. Lin GH, Lin LZ, Zhang Y, Pei WY, Zeng JC: Influence of fire needling on SiHua acupoints to physical condition and Thl/Th2 drift in advanced non-small cell lung cancer patients with chemotherapy. In: The 13th National Conference on new Advances in Comprehensive Treatment of Cancer [第13届全國腫瘤綜合治療新进展學術大會. 第二届中國民族医藥學會腫瘤分會學術年會. 世界中医藥學會聯合會癌症姑息治療硏究專業委員會成立大會論文集]; 广州. 2016: 178-182.
  18. Lin GH, Lin LZ, Zhang Y, Pei Wy, Zeng JC, Zhao WX: Influence of fire needle stimulation at Sihua acupoints on performance status and Th1/Th2 balance in the patients with advanced non-smal cel lung cancer after chemotherapy. Acupuncture Research 2019, 44(02):136-139.
  19. Pei WY: Based on Th1/Th2, MMPs/TIMPs to research the influence of fire needle on SiHua acupoint in chemotherapy patients with non-small cell lung cancer. Guangzhou University of Chinese Medicine; 2016.
  20. Shi LL, Zhou H, Tong WP: Regulation of T lymphocyte immune function by acupuncture in patients undergoing lung cancer surgery [針刺對肺癌手術患者T淋巴細胞免疫功能的調節]. Shanghai Journal of Acupuncture and Moxibustion 2003, 22(12):27-27. https://doi.org/10.3969/j.issn.1005-0957.2003.12.014
  21. Wang XY: The influence of blood lymphocyte subsets through electric acupuncture after palliative chemotherapy for non-small cell lung cancer. Zhejiang Chinese Medical University; 2015.
  22. Wang XY, Fang HM, Wang Y, Wang H: The influence of immune function through electric acupuncture after palliative chemotherapy for non-small cell lung cancer [電針對非小細胞肺癌姑息化療患者免疫功能的影響]. Modern Practical Medicine 2016, 28(8):1009-1011.
  23. Wang H, Wang Y, Fang HM: Treatment of 30 cases of cancer pain with electroacupuncture syndrome differentiation [電針辨証治療肺癌癌痛30例]. Henan Traditional Chinese Medicine 2018, 38(3):454-457.
  24. Wang Yl, LI JX, Guo XQ, FU RY, Guan XJ: Effect of acupuncture in different time on nausea and vomiting induced by chemotherapy of lung cancer. Chinese Acupuncture & Moxibustion 2019, 39(12):1269-1273.
  25. Xu YL: Influence on IL-2, TNF-a and T lymphocyte subsets level with fire needle SiHua in chemotherapy patients with lung cancer. GuangZhou University of Chinese Medicine; 2012.
  26. Yan JS: Clinical research of acupuncture on cancer - related fatigue in patients with lung cancer ater chemoradiotherapy. Jinan University; 2018.
  27. Zhang Y: Influence of fire needling on SiHua to quality of life and Th1/Th2 drift in chemotherapy patients with advanced stage non-small cell lung cancer. GuangZhou University of Chinese Medicine; 2014.
  28. Fan LY, Gao SL, Wang YQ, Qi ZP: Clinical observation of acupuncture combined with psychological intervention in the treatment of moderate and severe pain in lung cancer [針刺聯合心理干預治療肺癌中重度疼痛的臨床觀察]. Home Medicine 2017(1):1-2.
  29. Fan LY, Gao SL, Wang YQ, Qi ZP: Clinical observation of acupuncture combined with western medicine in treatment of advanced lung cancer pain. Medical Journal of Chinese People's Health 2017, 29(11):36-38.
  30. Shen LF, Chen WY, Lv XD, Liu JL, Yang XM, Yao M, Ni HD: Study on the effect of electro acupuncture in improving sleep quality of patients with lung cancer - related pain. Journal of Medical Research 2016, 45(6):87-90.
  31. Wang Y: The clinical research of electro-acupuncture therapy combined with oxycontin to treat the pain of advanced non-small cell lung cancer. Zhejiang Chinese Medical University; 2016.
  32. Wang J: The clinical study warm acupuncture treatment of severe pain in bone metastasis of lung cancer. Guangzhou University of Chinese Medicine; 2019.
  33. Gao XY, Chong CY, Zhang SP, Cheng KWE, Zhu B: Temperature and Safety Profiles of Needle-Warming Techniques in Acupuncture and Moxibustion. Evidence-Based Complementary and Alternative Medicine 2012, 2012:168393. https://doi.org/10.1155/2012/168393
  34. Cabioglu MT, Cetin BE: Acupuncture and immunomodulation. The American journal of Chinese medicine 2008, 36(1):25-36. https://doi.org/10.1142/S0192415X08005552
  35. Rogers PA, Schoen AM, Limehouse J: Acupuncture for immune-mediated disorders. Literature review and clinical applications. Problems in veterinary medicine 1992, 4(1):162-193.
  36. Zhang J, Wang Y, Guo Y, Ji X, Wang S: Effect of electro-acupuncture at Zusanli acupoint on postoperative T cell immune function in rats. Nan Fang Yi Ke Da Xue Xue Bao 2018, 38(11):1384-1388.
  37. He Y, Guo X, May BH, Zhang AL, Liu Y, Lu C, Mao JJ, Xue CC, Zhang H: Clinical Evidence for Association of Acupuncture and Acupressure WithImproved Cancer Pain: A Systematic Review and Meta-Analysis. JAMA Oncol 2019, 6(2):271-278. https://doi.org/10.1001/jamaoncol.2019.5233
  38. Chiu HY, Hsieh YJ, Tsai PS: Systematic review and meta-analysis of acupuncture to reduce cancer-related pain. European Journal of Cancer Care 2017, 26(2):e12457. https://doi.org/10.1111/ecc.12457
  39. Hesketh PJ: Chemotherapy-Induced Nausea and Vomiting. New England Journal of Medicine 2008, 358(23):2482-2494. https://doi.org/10.1056/NEJMra0706547
  40. Huang ST, Chen GY, Lo HM, Lin JG, Lee YS, Kuo CD: Increase in the vagal modulation by acupuncture at neiguan point in the healthy subjects. The American journal of Chinese medicine 2005, 33(1):157-164. https://doi.org/10.1142/S0192415X0500276X
  41. MacPherson H, Altman DG, Hammerschlag R, Li Youping M, Wu Taixiang M, White A, Moher D, Grp SR: Revised STandards for Reporting Interventions in Clinical Trials of Acupuncture (STRICTA). Extending the CONSORT Statement 2010, 7(6):1-11.