Korean Journal of Radiology

The Korean Society of Radiology (대한영상의학회)
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Long-Term Clinical Effects of Carotid Intraplaque Neovascularization in Patients with Coronary Artery Disease

  • Hyemoon Chung (Cardiovascular Division, Department of Internal Medicine, Kyung Hee University Medical Center, Kyung Hee University) ;
  • Bu Yong Kim (Cardiovascular Division, Department of Internal Medicine, Kyung Hee University Medical Center, Kyung Hee University) ;
  • Hyun Soo Kim (Cardiovascular Division, Department of Internal Medicine, Kyung Hee University Medical Center, Kyung Hee University) ;
  • Hyung Oh Kim (Cardiovascular Division, Department of Internal Medicine, Kyung Hee University Medical Center, Kyung Hee University) ;
  • Jung Myung Lee (Cardiovascular Division, Department of Internal Medicine, Kyung Hee University Medical Center, Kyung Hee University) ;
  • Jong Shin Woo (Cardiovascular Division, Department of Internal Medicine, Kyung Hee University Medical Center, Kyung Hee University) ;
  • Jin Bae Kim (Cardiovascular Division, Department of Internal Medicine, Kyung Hee University Medical Center, Kyung Hee University) ;
  • Woo-Shik Kim (Cardiovascular Division, Department of Internal Medicine, Kyung Hee University Medical Center, Kyung Hee University) ;
  • Kwon Sam Kim (Cardiovascular Division, Department of Internal Medicine, Kyung Hee University Medical Center, Kyung Hee University) ;
  • Weon Kim (Cardiovascular Division, Department of Internal Medicine, Kyung Hee University Medical Center, Kyung Hee University)
  • Received : 2019.07.22
  • Accepted : 2020.02.09
  • Published : 2020.07.01
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Abstract

Objective: To investigate the predictive value of intraplaque neovascularization (IPN) for cardiovascular outcomes. Materials and Methods: We evaluated 217 patients with coronary artery disease (CAD) (158 men; mean age, 68 ± 10 years) with a maximal carotid plaque thickness ≥ 1.5 mm for the presence of IPN using contrast-enhanced ultrasonography. We compared patients with (n = 116) and without (n = 101) IPN during the follow-up period and investigated the predictors of major adverse cardiovascular events (MACE), including cardiac death, myocardial infarction, coronary artery revascularization, and transient ischemic accident/stroke. Results: During the mean follow-up period of 995 ± 610 days, the MACE rate was 6% (13/217). Patients with IPN had a higher maximal thickness than those without IPN (2.86 ± 1.01 vs. 2.61 ± 0.84 mm, p = 0.046). Common carotid artery-peak systolic velocity, left ventricular mass index (LVMI), and ventricular-vascular coupling index were significantly correlated with MACE. However, on multivariate Cox regression analysis, increased LVMI was independently related to MACE (p < 0.05). The presence of IPN could not predict MACE. Conclusion: The presence of IPN was related to a higher plaque thickness but could not predict cardiovascular outcomes better than conventional clinical factors in patients with CAD.

Keywords

Acknowledgement

We thank the study participants for making this study possible.

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