Journal of Animal Reproduction and Biotechnology (한국동물생명공학회지)

The Korean Society of Animal Reproduction and Biotechnology (한국동물생명공학회)
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The role of hepatic stellate cells in fibrotic liver diseases

  • Cho, Hye Jin (Graduate School of International Agricultural Technology, Seoul National University) ;
  • Jang, Jae Young (Department of Life Sciences, College of BioNano Technology, Gachon University) ;
  • Kim, Tae Min (Graduate School of International Agricultural Technology, Seoul National University)
  • Received : 2020.03.24
  • Accepted : 2020.05.08
  • Published : 2020.06.30
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Abstract

Hepatic stellate cells (HSCs) play essential roles in normal and pathophysiological function in liver. In steady state, HSCs contribute to retinoid storage, immune tolerance, and extracellular matrix (ECM) homeostasis. Upon liver injury, they become activated and lead to morphological and functional changes. Studies have demonstrated that activation of HSCs by various stimuli such as toxins, microbial infection, or metabolic overload can promote the fibrotic changes in liver by production of ECM. Herein, we provide current knowledge about the basic characteristics of HSCs and the mechanism by which they are activated.

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References

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