Journal of Periodontal and Implant Science

Korean Academy of Periodontology (대한치주과학회)
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Open healing of contained and non-contained extraction sockets covered with a ribose cross-linked collagen membrane: a pilot study

  • Friedmann, Anton (Department of Periodontology, Witten/Herdecke University Faculty of Health) ;
  • Meskeleviciene, Viktorija (Department of Periodontology, Witten/Herdecke University Faculty of Health) ;
  • Yildiz, Mehmet Selim (Department of Periodontology, Witten/Herdecke University Faculty of Health) ;
  • Gotz, Werner (Department of Orthodontics, Oral Biology Laboratory, University of Bonn) ;
  • Park, Jung-Chul (Department of Periodontology, Dankook University College of Dentistry) ;
  • Fischer, Kai R. (Department of Periodontology, Witten/Herdecke University Faculty of Health)
  • Received : 2020.01.14
  • Accepted : 2020.08.27
  • Published : 2020.12.31
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Abstract

Purpose: This study investigated whether the placement of ribose cross-linked collagen (RCLC) membranes without primary soft tissue closure predictably resulted in sufficient alveolar ridge preservation in contained and non-contained extraction sockets. Methods: Membranes were positioned across extraction sockets, undermining full-thickness flaps, and the gingival margins were fixed by double-interrupted sutures without crossed horizontal mattress sutures for 1 week. In non-contained sockets, a bone substitute was used to support the membrane within the bony envelope. Radiographs and clinical images obtained 4 months later were analyzed by ImageJ software using non-parametric tests. Results: In 18 patients, 20 extraction sockets healed uneventfully and all sites received standard-diameter implants (4.1, 4.8, or 5.0 mm) without additional bone augmentation. Soft tissues and the muco-gingival border were well maintained. A retrospective analysis of X-rays and clinical photographs showed non-significant shrinkage in the vertical and horizontal dimensions (P=0.575 and P=0.444, respectively). The new bone contained vital bone cells embedded in mineralized tissues. Conclusions: Within the limitations of this pilot study, open healing of RCLC membranes may result in sufficient bone volume for implant placement without additional bone augmentation in contained and non-contained extraction sockets.

Keywords

Acknowledgement

The authors deeply appreciate the help of Ms. van Dyke and Ms. Bay for assistance in histological processing. The authors are grateful to Dr. Ozgun Pehlivan, Bolu Abant Izzet Baysal University, School of Medicine, Department of Public Health for proofreading the methodology, verifying the results by double-checking the calculations, and revising the conclusions.

References

  1. Schropp L, Wenzel A, Kostopoulos L, Karring T. Bone healing and soft tissue contour changes following single-tooth extraction: a clinical and radiographic 12-month prospective study. Int J Periodontics Restorative Dent 2003;23:313-23.
  2. Misawa M, Lindhe J, Araujo MG. The alveolar process following single-tooth extraction: a study of maxillary incisor and premolar sites in man. Clin Oral Implants Res 2016;27:884-9. https://doi.org/10.1111/clr.12710
  3. Chappuis V, Engel O, Reyes M, Shahim K, Nolte LP, Buser D. Ridge alterations post-extraction in the esthetic zone: a 3D analysis with CBCT. J Dent Res 2013;92:195S-201S. https://doi.org/10.1177/0022034513506713
  4. Chappuis V, Engel O, Shahim K, Reyes M, Katsaros C, Buser D. Soft tissue alterations in esthetic postextraction sites: a 3-dimensional analysis. J Dent Res 2015;94:187S-193S. https://doi.org/10.1177/0022034515592869
  5. Chappuis V, Rahman L, Buser R, Janner SF, Belser UC, Buser D. Effectiveness of contour augmentation with guided bone regeneration: 10-year results. J Dent Res 2018;97:266-74. https://doi.org/10.1177/0022034517737755
  6. Engler-Hamm D, Cheung WS, Yen A, Stark PC, Griffin T. Ridge preservation using a composite bone graft and a bioabsorbable membrane with and without primary wound closure: a comparative clinical trial. J Periodontol 2011;82:377-87. https://doi.org/10.1902/jop.2010.090342
  7. Avila-Ortiz G, Elangovan S, Kramer KW, Blanchette D, Dawson DV. Effect of alveolar ridge preservation after tooth extraction: a systematic review and meta-analysis. J Dent Res 2014;93:950-8. https://doi.org/10.1177/0022034514541127
  8. Barone A, Borgia V, Covani U, Ricci M, Piattelli A, Iezzi G. Flap versus flapless procedure for ridge preservation in alveolar extraction sockets: a histological evaluation in a randomized clinical trial. Clin Oral Implants Res 2015;26:806-13. https://doi.org/10.1111/clr.12358
  9. Barone A, Toti P, Quaranta A, Alfonsi F, Cucchi A, Calvo-Guirado JL, et al. Volumetric analysis of remodelling pattern after ridge preservation comparing use of two types of xenografts. A multicentre randomized clinical trial. Clin Oral Implants Res 2016;27:e105-15. https://doi.org/10.1111/clr.12572
  10. Chappuis V, Araujo MG, Buser D. Clinical relevance of dimensional bone and soft tissue alterations postextraction in esthetic sites. Periodontol 2000 2017;73:73-83. https://doi.org/10.1111/prd.12167
  11. Mardas N, Chadha V, Donos N. Alveolar ridge preservation with guided bone regeneration and a synthetic bone substitute or a bovine-derived xenograft: a randomized, controlled clinical trial. Clin Oral Implants Res 2010;21:688-98. https://doi.org/10.1111/j.1600-0501.2010.01918.x
  12. Avila-Ortiz G, Rodriguez JC, Rudek I, Benavides E, Rios H, Wang HL. Effectiveness of three different alveolar ridge preservation techniques: a pilot randomized controlled trial. Int J Periodontics Restorative Dent 2014;34:509-21. https://doi.org/10.11607/prd.1838
  13. Aimetti M, Manavella V, Corano L, Ercoli E, Bignardi C, Romano F. Three-dimensional analysis of bone remodeling following ridge augmentation of compromised extraction sockets in periodontitis patients: a randomized controlled study. Clin Oral Implants Res 2018;29:202-14.
  14. Cho IW, Park JC, Shin HS. A comparison of different compressive forces on graft materials during alveolar ridge preservation. J Periodontal Implant Sci 2017;47:51-63. https://doi.org/10.5051/jpis.2017.47.1.51
  15. Choi HK, Cho HY, Lee SJ, Cho IW, Shin HS, Koo KT, et al. Alveolar ridge preservation with an openhealing approach using single-layer or double-layer coverage with collagen membranes. J Periodontal Implant Sci 2017;47:372-80. https://doi.org/10.5051/jpis.2017.47.6.372
  16. Park JC, Koo KT, Lim HC. The hidden X suture: a technical note on a novel suture technique for alveolar ridge preservation. J Periodontal Implant Sci 2016;46:415-25. https://doi.org/10.5051/jpis.2016.46.6.415
  17. Klinger A, Asad R, Shapira L, Zubery Y. In vivo degradation of collagen barrier membranes exposed to the oral cavity. Clin Oral Implants Res 2010;21:873-6.
  18. Zubery Y, Nir E, Goldlust A. Ossification of a collagen membrane cross-linked by sugar: a human case series. J Periodontol 2008;79:1101-7. https://doi.org/10.1902/jop.2008.070421
  19. Friedmann A, Strietzel FP, Maretzki B, Pitaru S, Bernimoulin JP. Observations on a new collagen barrier membrane in 16 consecutively treated patients. Clinical and histological findings. J Periodontol 2001;72:1616-23. https://doi.org/10.1902/jop.2001.72.11.1616
  20. Rueden CT, Schindelin J, Hiner MC, DeZonia BE, Walter AE, Arena ET, et al. ImageJ2: ImageJ for the next generation of scientific image data. BMC Bioinformatics 2017;18:529. https://doi.org/10.1186/s12859-017-1934-z
  21. Koutouzis T, Lipton D. Regenerative needs following alveolar ridge preservation procedures in compromised and noncompromised extraction sockets: a cone beam computed tomography study. Int J Oral Maxillofac Implants 2016;31:849-54. https://doi.org/10.11607/jomi.4437
  22. Flugge T, Nelson K, Nack C, Stricker A, Nahles S. 2-Dimensional changes of the soft tissue profile of augmented and non-augmented human extraction sockets: a randomized pilot study. J Clin Periodontol 2015;42:390-7. https://doi.org/10.1111/jcpe.12386
  23. Lekholm U, Zarb GA. Patient selection. In: Branemark PI, Zarb GA, Albrektsson T, editors. Tissueintegrated prosthesis: osseointegration in clinical dentistry. Chicago (IL): Quintessence; 1985. p.195-205.