한국발생생물학회지:발생과생식 (Development and Reproduction)

  • 제24권4호
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  • Pages.263-275
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  • 2020
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  • 2465-9525(pISSN)
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  • 2465-9541(eISSN)
한국발생생물학회 (The Korean Society of Developmental Biology)
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The Effects of Daily Melatonin Gavage on Reproductive Activity in the Male Syrian Hamsters

  • Jeon, Geon Hyung (Dept. of Life Science, College of Environmental Sciences, Yong-In University) ;
  • Kim, Hyeon Jeong (Dept. of Life Science, College of Environmental Sciences, Yong-In University) ;
  • Park, Jinsoo (Dept. of Biotechnology, Sangmyung University) ;
  • Lee, Sung-Ho (Dept. of Biotechnology, Sangmyung University) ;
  • Cheon, Yong-Pil (Division of Developmental Biology and Physiology, Dept. of Biotechnology, Sungshin University) ;
  • Choi, Donchan (Dept. of Life Science, College of Environmental Sciences, Yong-In University)
  • 투고 : 2020.11.11
  • 심사 : 2020.11.30
  • 발행 : 2020.12.31
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초록

The proper administration of melatonin has well been documented to induce testicular regression in seasonal breeding animals. The subcutaneous injections of melatonin in the afternoon, not in the morning, consistently occurred testicular involution in the male Syrian (golden) hamsters whose reproductive activity is regulated by the photoperiod. But the effects of daily melatonin via gavage have not been estimated. Golden hamsters housed in long photoperiod (LP) were divided into 5 groups: the control animals housed in LP or in short photoperiod (SP) and animals treated daily with low (15 ㎍), middle (150 ㎍), and high dosages (1,500 ㎍) of pure melatonin by using gavage in the evening for 8 weeks. As results, LP control animals had large testes and SP controls displayed small and entirely regressed testes. The animals treated with various dosages of melatonin showed collectively degenerating effects on the weights of testes, epididymides, and seminal vesicles in the middle and high dosage groups, with the individual differences as well. The high dosages induced testicular regression in more proportion than the middle dosages did. The low dosage had large testes like the LP control animals. The small and inactive testes shown in some animals of both middle and high groups presented the complete regression as those of the animals maintained in SP. These results strongly suggest that the administrations of melatonin lead to testicular involution in the male golden hamsters when it is administered through gavage.

키워드

과제정보

This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2017R1D1A1B03028581).

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