Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Terpenoids from Citrus unshiu Peels and Their Effects on NO Production

  • Vu, Thi Oanh (College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University) ;
  • Seo, Wonyoung (Department of Biochemistry, College of Natural Sciences, Kangwon National University) ;
  • Lee, Jeong Hyung (Department of Biochemistry, College of Natural Sciences, Kangwon National University) ;
  • Min, Byung Sun (College of Pharmacy, Drug Research and Development Center, Daegu Catholic University) ;
  • Kim, Jeong Ah (College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University)
  • Received : 2020.05.11
  • Accepted : 2020.06.14
  • Published : 2020.06.30
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Abstract

Two new compounds, 3-methyl-but-2-en-1-yl-1-O-β-xylopyranosyl-(1"→2')-O-β-glucopyranoside (1) and 1-O-β-glucopyranosyl-6-hydroxy-2-methyl-hep-2-enoic acid (2), along with sixteen known terpenoids were isolated from the peels of Citrus unshiu Markov. Their structures were elucidated based on extensive NMR analyses (1H NMR, 13C NMR, DEPT, COSY, HMQC, and HMBC) and high-resolution mass spectrometry. In addition, all isolates (1 - 18) were tested their effects on nitric oxide (NO) production in RAW264.7 cells. Limonin (15) showed to inhibit LPS-induced NO production in a concentration-dependent manner without cytotoxicity.

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References

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