한국임상약학회지 (Korean Journal of Clinical Pharmacy)

  • 제30권2호
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  • Pages.81-86
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  • 2020
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  • 1226-6051(pISSN)
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  • 2508-786X(eISSN)
한국임상약학회 (Korean College Of Clinical Pharmacy)
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노인 치매 환자의 항정신병약물 및 항파킨슨약물 처방 현황

The Prescribing Patterns of Antipsychotic Drugs and Antiparkinsonian Drugs in Elderly Patients with Dementia

  • 윤수미 (동덕여자대학교 약학대학) ;
  • 이승원 (연세대학교 의과대학 정신과학교실) ;
  • 장지은 (동덕여자대학교 약학대학) ;
  • 이영숙 (계명대학교 약학대학) ;
  • 유기연 (동덕여자대학교 약학대학)
  • Yoon, Soo Mi (College of Pharmacy, Dongduk Women's University) ;
  • Lee, Sungwon (Department of Psychiatry, Yonsei University College of Medicine) ;
  • Chang, Ji-Eun (College of Pharmacy, Dongduk Women's University) ;
  • Lee, Young Sook (Department of Pharmacy, Keimyung University) ;
  • Rhew, Kiyon (College of Pharmacy, Dongduk Women's University)
  • 투고 : 2020.02.27
  • 심사 : 2020.05.06
  • 발행 : 2020.06.30
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초록

Background: The number of patients with dementia continues to increase as the age of aging continues to grow. Psychiatric symptoms caused by senile dementia are controlled using antipsychotics. However, these antipsychotics can lead to Parkinson's disease, and abuse of dopamine derivatives such as levodopa among Parkinsonian drugs can lead to psychosis. Therefore, we evaluated the patterns of prescribed antipsychotics and antiparkinsonian drugs in patients with senile dementia. Methods: We used data from the sample of elderly patients from the Health Insurance Review and Assessment Service (HIRA-APS-2016). We analyzed the patterns of prescribing antipsychotics and antiparkinsonian drugs including prescribed daily dosage, period of prescription, and number of patients with both antipsychotics and antiparkinsonian drugs for senile dementia. Results: Among the 159,391 patients with dementia included in this analysis, 4,963 patients (3.1%) and 16,499 patients (10.4%) were prescribed typical and atypical antipsychotic drugs, respectively. The most frequently prescribed typical antipsychotic was haloperidol (4,351 patients with dementia), whereas the atypical agent was quetiapine (12,719 patients). The most frequently prescribed antiparkinsonian drugs were in the order of levodopa/carbidopa, benztropine, and ropinirole. In addition, 1,103 and 3,508 patients prescribed typical and atypical antipsychotics, respectively, were co-prescribed antiparkinsonian drugs. Conclusions: Atypical antipsychotics were the preferred prescription in patients with senile dementia. The prescription dose was relatively low; however, the average treatment duration was mostly long-term. Selection of antipsychotics and/or antiparkinsonian drugs should be made carefully in senile dementia and the causal relationship of adverse drug reactions needs further study.

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