International Journal of Oral Biology

  • 제45권2호
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  • Pages.33-41
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  • 2020
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  • 1226-7155(pISSN)
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  • 2287-6618(eISSN)
대한구강생물학회 (The Korean Academy of Oral Biology)
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Flavonoids as anti-inflammatory and neuroprotective agents

  • Lee, Heesu (Department of Anatomy, College of Dentistry, Gangneung-Wonju National University) ;
  • Selvaraj, Baskar (Natural Product Research Center, Korea Institute of Science and Technology) ;
  • Yoo, Ki Yeon (Department of Anatomy, College of Dentistry, Gangneung-Wonju National University) ;
  • Ko, Seong-Hee (Department of Pharmacology, College of Dentistry and Research Institute of Oral Science, Gangneung-Wonju National University)
  • 투고 : 2020.02.20
  • 심사 : 2020.04.22
  • 발행 : 2020.06.30
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초록

Neuroinflammation is known as the main mechanism implicated in the advancement of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. The main feature of neuroinflammation is associated with the activation of microglia. The activated microglia increase proinflammatory cytokine production and induce progressive neuronal cell death. Citrus flavonoids show neuroprotective effects that are associated with the anti-inflammatory action of flavonoids in neurodegenerative diseases. Among these citrus flavonoids, kaempferol, naringin, and nobiletin show inhibitory effects on nuclear factor-κB and mitogen-activated protein kinase signaling pathways that can modulate inflammatory conditions in microglial cells. In the present review, we present the anti-inflammatory activities of citrus flavonoids and therapeutic potential of flavonoids as neuroprotective agents.

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참고문헌

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