Journal of Gastric Cancer

The Korean Gastric Cancer Association (대한위암학회)
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Association between the MUC1 rs4072037 Polymorphism and Risk of Gastric Cancer and Clinical Outcomes

  • Kim, Beom Su (Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Lee, Inchul (Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Yook, Jeong Hwan (Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Song, Kyuyoung (Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine) ;
  • Kim, Byung-Sik (Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine)
  • Received : 2019.10.01
  • Accepted : 2020.03.08
  • Published : 2020.06.30
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Abstract

Purpose: Mucin 1 (MUC1) was identified as a gastric cancer (GC) susceptibility gene by genome-wide association studies in Asians and candidate gene studies in Europeans. This study aimed to investigate the association between the MUC1 rs4072037 polymorphism and GC in terms of the Lauren classification and long-term clinical outcomes. Materials and Methods: A total of 803 patients with GC and 816 unrelated healthy controls were enrolled in the study. The association between the MUC1 rs4072037 variant and GC histological types and clinical outcomes, including tumor recurrence and prognosis was investigated. Results: The major A allele of rs4072037 was associated with increased GC risk (P<0.05). In subtype analysis, the association was most significant for diffuse-type GC (P<0.05) and in a dominant model (P<0.05), whereas there was no association with intestinal-type GC (P>0.05). Cox proportional hazards analysis revealed the heterozygote AG rs4072037 allele as an independent risk factor influencing tumor recurrence and disease-related death in diffusetype GC (P<0.05). but not in intestinal-type GC (P>0.05). Conclusions: The exonic single nucleotide polymorphism rs4072037 in MUC1 was associated with diffuse-type GC and was an independent risk factor influencing tumor recurrence and disease-related death in diffuse-type GC.

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References

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