DOI QR코드

DOI QR Code

Basaloid Squamous Cell Carcinoma of the Lung: Two Case Reports with CT Imaging Findings

폐의 기저세포양 편평세포암: 두 개의 증례 보고와 전산화단층촬영 영상소견

  • Joo Hee Kim (Department of Radiology, Veterans Health Service Medical Center) ;
  • Hyun Jung Yoon (Department of Radiology, Veterans Health Service Medical Center) ;
  • Eunju Lee (Department of Radiology, Veterans Health Service Medical Center) ;
  • Eun Ju Kim (Department of Pathology, Veterans Health Service Medical Center)
  • 김주희 (중앙보훈병원 영상의학과) ;
  • 윤현정 (중앙보훈병원 영상의학과) ;
  • 이은주 (중앙보훈병원 영상의학과) ;
  • 김은주 (중앙보훈병원 병리과)
  • Received : 2019.07.03
  • Accepted : 2019.08.12
  • Published : 2020.05.01

Abstract

Basaloid squamous cell carcinoma of the lung is now considered a subtype of squamous cell carcinoma as per the 2015 WHO classification and remains a relatively unknown type of lung cancer due to its rarity. Here we report two cases of basaloid squamous cell carcinoma of the lung and their CT findings to clarify some of the radiologic features of this type of cancer. Two patients aged 85 and 68 years with lung basaloid squamous cell carcinoma visited our institution and underwent surgical resection. On CT, the lesions were 3.1 and 2.8 cm in size, respectively, well-defined, round in shape with lobulated margins and prominent intratumoral necrosis. The latter case was followed after operation for 20 months, and there was no recurrence of the disease on CT. Although very rare, basaloid squamous cell carcinoma should be considered a subtype of lung cancer in tumors sharing these CT findings.

폐의 기저세포양 편평세포암은 2015년 WHO 분류체계에서 편평세포암의 한 아형으로 분류되었고 폐암에서는 드물기에 잘 알려지지 않은 유형이다. 저자들은 두 기저세포양 편평세포암 증례를 보고하고 이들의 전산화단층촬영 영상소견을 명시하고자 한다. 85세 그리고 68세의 기저세포양 편평세포암을 가진 환자가 내원하여 수술적 절제를 시행 받았다. 전산화단층 촬영에서 두 병변은 각각 3.1과 2.8 cm 크기로 경계가 좋으며, 둥글면서 소엽상 경계였고 내부는 괴사를 시사하는 저음영이 풍부하였다. 후자는 수술 후 20개월 동안 추적 관찰하였고 전산화단층촬영에서 재발은 없었다. 비록 드문 아형의 폐암이지만 이러한 전산화단층촬영 소견을 공유한다면 기저세포양 편평세포암을 고려해 볼 수 있겠다.

Keywords

Acknowledgement

This study was supported by a Veterans Health Service (VHS) Medical Center Research Grant, Republic of Korea (grant number: VHSMC 18040).

References

  1. Travis WD, Brambilla E, Nicholson AG, Yatabe Y, Austin JHM, Beasley MB, et al. The 2015 World Health Organization classification of lung tumors: impact of genetic, clinical and radiologic advances since the 2004 classification. J Thorac Oncol 2015;10:1243-1260
  2. Wang LC, Wang L, Kwauk S, Woo JA, Wu LQ, Zhu H, et al. Analysis on the clinical features of 22 basaloid squamous cell carcinoma of the lung. J Cardiothorac Surg 2011;6:10
  3. Moro-Sibilot D, Lantuejoul S, Diab S, Moulai N, Aubert A, Timsit JF, et al. Lung carcinomas with a basaloid pattern: a study of 90 cases focusing on their poor prognosis. Eur Respir J 2008;31:854-859
  4. Foroulis CN, Iliadis KH, Mauroudis PM, Kosmidis PA. Basaloid carcinoma, a rare primary lung neoplasm: report of a case and review of the literature. Lung Cancer 2002;35:335-338
  5. Cakir E, Demirag F, Ucoluk GO, Kaya S, Memis L. Basaloid squamous cell carcinoma of the lung: a rare tumour with a rare clinical presentation. Lung Cancer 2007;57:109-111
  6. Nagakawa H, Hiroshima K, Takiguchi Y, Yatomi M, Takahashi Y, Mikami M, et al. Basaloid squamous-cell carcinoma of the lung in a young woman. Int J Clin Oncol 2006;11:66-68
  7. Brambilla E, Moro D, Veale D, Brichon PY, Stoebner P, Paramelle B, et al. Basal cell (basaloid) carcinoma of the lung: a new morphologic and phenotypic entity with separate prognostic significance. Hum Pathol 1992;23:993-1003
  8. Hollings N, Shaw P. Diagnostic imaging of lung cancer. Eur Respir J 2002;19:722-742
  9. Kim DJ, Kim KD, Shin DH, Ro JY, Chung KY. Basaloid carcinoma of the lung: a really dismal histologic variant? Ann Thorac Surg 2003;76:1833-1837
  10. Moro D, Brichon PY, Brambilla E, Veale D, Labat F, Brambilla C. Basaloid bronchial carcinoma. A histologic group with a poor prognosis. Cancer 1994;73:2734-2739