Journal of the Korean Society of Radiology (대한영상의학회지)

The Korean Society of Radiology (대한영상의학회)
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Predictors of a Favorable Outcome after Emergent Carotid Artery Stenting in Acute Anterior Circulation Stroke Patients

급성 전방순환 뇌경색 환자에서 응급 경동맥 스텐트 삽입술 후 양호한 임상 결과의 예측인자

  • Gyeong Il Moon (Department of Radiology, Chonnam National University Medical School) ;
  • Byung Hyun Baek (Department of Radiology, Chonnam National University Medical School) ;
  • Seul Kee Kim (Department of Radiology, Chonnam National University Hwasun Hospital) ;
  • Yun Young Lee (Department of Radiology, Chonnam National University Medical School) ;
  • Hyo-Jae Lee (Department of Radiology, Chonnam National University Medical School) ;
  • Woong Yoon (Department of Radiology, Chonnam National University Medical School)
  • 문경일 (전남대학교 의과대학 영상의학교실) ;
  • 백병현 (전남대학교 의과대학 영상의학교실) ;
  • 김슬기 (화순전남대학교병원 영상의학과) ;
  • 이윤영 (전남대학교 의과대학 영상의학교실) ;
  • 이효재 (전남대학교 의과대학 영상의학교실) ;
  • 윤웅 (전남대학교 의과대학 영상의학교실)
  • Received : 2019.06.27
  • Accepted : 2019.09.14
  • Published : 2020.05.01
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Abstract

Purpose This study aimed to identify independent predictors of favorable outcomes associated with emergent carotid artery stenting (CAS) in patients with acute anterior circulation stroke. Materials and Methods This study included 93 patients with acute stroke who underwent emergent CAS to treat stenoocclusive lesions in the cervical internal carotid artery (ICA) within 6 hours of the onset of the associated symptoms. Data were compared between patients with and without favorable outcomes. The independent predictors of a favorable outcome were determined via logistic regression analysis (modified Rankin Scale 0-2 at 90 days). Results Intracranial tandem occlusion was noted in 81.7% of patients (76/93) among which (76/93), 55 of whom underwent intracranial recanalization therapy. Intracranial reperfusion was successful in 74.2% (69/93) and favorable outcomes were noted in 51.6% of patients (48/93). The mortality rate was 6.5% (6/93). In logistic regression analysis, diffusion-weighted imaging-Alberta Stroke Program Early CT Score [odds ratio (OR), 1.487; 95% confidence interval (CI), 1.018-2.173, p = 0.04], successful reperfusion (OR, 5.199; 95% CI, 1.566-17.265, p = 0.007), and parenchymal hemorrhage (OR, 0.042; 95% CI, 0.003-0.522, p = 0.014) were independently associated with a favorable outcome. Conclusion Baseline infarct size, reperfusion status, and parenchymal hemorrhage were independent predictors of favorable outcomes after emergent CAS to treat stenoocclusive lesions in the cervical ICA in patients with acute anterior circulation stroke.

목적 이 연구는 경동맥 폐쇄성 병변에 의해 발생한 급성 뇌경색 환자에서 응급 경동맥 스텐트 설치술 후 양호한 임상 결과의 독립적인 예측인자를 알아보고자 하였다. 대상 및 방법 경동맥 폐쇄성 병변에 의한 급성 뇌경색 증상 발생 후 6시간 이내에 응급 경동맥 스텐트 설치술을 시행 받은 93명의 환자를 대상으로 하였다. 양호한 임상 결과를 보인 군과 불량한 임상 결과를 보인 군 간의 인자들을 비교하였으며, 양호한 임상 결과(3개월째 modified Rankin Scale 2 이하)를 예측하는 독립인자를 알아보기 위하여 로지스틱 회귀 분석을 사용하였다. 결과 76명(81.7%)의 환자가 두개내 중복폐색을 동반하였으며, 이들 중 55명이 두개내 재개통치료를 시행 받았다. 전체적인 혈관 재개통 성공률은 74.2%(69/93)였다. 3개월째 양호한 임상 결과의 비율은 51.6%(48/93)였으며 사망률은 6.5%(6/93)였다. 이분형 로지스틱 회귀분석에서 diffusion-weighted imaging-Alberta Stroke Program Early CT Score [odds ratio (이하 OR), 1.487; 95% confidence interval (이하 CI), 1.018-2.173, p = 0.04], 성공적인 재관류(OR, 5.199; 95% CI, 1.566-17.265, p = 0.007), 뇌실질 출혈(OR, 0.042; 95% CI, 0.003-0.522, p = 0.014) 등이 양호한 임상 결과를 예측하는 독립인자였다. 결론 초기 뇌경색 크기, 혈관 재관류, 그리고 실질성 뇌출혈 등이 급성 뇌경색 환자에서 응급경동맥 스텐트 설치술 후 양호한 임상 결과를 예측하는 독립인자였다.

Keywords

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