Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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Liver Protective Effects of Jageum-Jung in Alcohol-induced liver injury mice model

알코올 유발 간 손상 마우스 모델에서 자금정의 간 보호 효과

  • Kim, Kwang-Youn (Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine (KIOM)) ;
  • Park, Kwang-Il (Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine (KIOM)) ;
  • Cho, Won-Kyung (Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine (KIOM)) ;
  • Ma, Jin-Yeul (Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine (KIOM))
  • 김광연 (한국한의학연구원 한의기술응용센터) ;
  • 박광일 (한국한의학연구원 한의기술응용센터) ;
  • 조원경 (한국한의학연구원 한의기술응용센터) ;
  • 마진열 (한국한의학연구원 한의기술응용센터)
  • Received : 2020.04.24
  • Accepted : 2020.05.28
  • Published : 2020.05.31
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Abstract

Objectives : This study investigated the hepatoprotective effects effects of Jageum-jung extract on alcohol-induced liver disease mice model. Methods : Alcoholic liver disease was induced by Ethanol in C57/BL6 male mice, which were fed Lieber-DeCarli liquid diet containing ethanol. Jageum-jung (100,200 and 300 mg/kg bw/day) were orally administered daily in the alcoholic fatty liver disease mice for 16 days. Results : The results indicate that Jageum-jung promotes hepatoprotective effects by significantly reducing aspartate transaminase (AST) and alanine transaminase (ALT) levels as indicators of liver damage in the serum. Furthermore, Jageum-jung decreased accumulation of triglyceride and total cholesterol, increased levels of superoxide dismutase (SOD) and glutathione (GSH) in the serum of the alcoholic fatty liver disease mice model. Additionally, it improved the serum alcohol dehydrogenase (ADH) activity. Conclusions : This study confirmed the anti-oxidative and hangover elimination effects of Jageum-jung extract, and suggests the possibility of using Jageum-jung to treat alcholic liver disease.

Keywords

References

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