Clinical Pain

  • 제19권2호
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  • Pages.59-63
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  • 2020
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  • 1598-5490(pISSN)
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  • 2765-5156(eISSN)
대한임상통증학회 (Korean Association of Pain Medicine)
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DOI QR코드

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회전근개파열에서 힘줄뼈부착부 개선을 위한 다상 스캐폴드의 유용성

Usefulness of Multiphase Scaffolds for Improving Tendon to Bone Healing for Rotator Cuff Tears in Shoulder

  • 이상철 (연세대학교 의과대학 재활의학교실)
  • Lee, Sang Chul (Department of Rehabilitation Medicine and Research Institute, Yonsei University College of Medicine)
  • 투고 : 2020.10.27
  • 심사 : 2020.11.17
  • 발행 : 2020.12.31
⟨ 이전 논문 다음 논문 ⟩

초록

Rotator cuff tear is often cited as a reason for shoulder pain and dysfunction in patients > 40 years of age. Surgical repair of rotator cuff tear is one of the most commonly performed orthopedic surgical procedures. Until now, the success rate of surgical repair for rotator cuff tear has not been satisfactory. Many factors influence the process of rotator cuff repair such as the presence of tendinosis and fatty infiltration, but the main factor is the difficulty in achieving healing at the tendon to bone interface. There is a clinical need for bioengineering approaches to promote regeneration of the native enthesis and reduce the poor outcomes after surgical repair. Toward this end, the design and fabrication of multiphasic or hierarchically structured scaffolds have received great attention. This manuscript deals with information on the tendon to bone interface and tries to find out why a multiphasic scaffold is necessary to reproduce it and considerations that need to be taken into to make an ideal scaffold.

키워드

참고문헌

  1. Galatz LM, Sandell LJ, Rothermich SY, Das R, Mastny A, Havlioglu N, et al. Characteristics of the rat supraspinatus tendon during tendon-to-bone healing after acute injury. J Orthop Res 2006; 24: 541-550 https://doi.org/10.1002/jor.20067
  2. Thomopoulos S, Williams GR, Soslowsky LJ. Tendon to bone healing: differences in biomechanical, structural, and compositional properties due to a range of activity levels. J Biomech Eng 2003; 125: 106-113 https://doi.org/10.1115/1.1536660
  3. Gulotta LV, Kovacevic D, Ehteshami JR, Dagher E, Packer JD, Rodeo SA. Application of bone marrow-derived mesenchymal stem cells in a rotator cuff repair model. Am J Sports Med 2009; 37: 2126-2133 https://doi.org/10.1177/0363546509339582
  4. Cole BJ, McCarty 3rd LP, Kang RW, Alford W, Lewis PB, Hayden JK. Arthroscopic rotator cuff repair: prospective functional outcome and repair integrity at minimum 2-year follow-up. J Shoulder Elbow Surg 2007; 16: 579-585 https://doi.org/10.1016/j.jse.2006.12.011
  5. Schwartz AG, Pasteris JD, Genin GM, Daulton TL, Thomopoulos S. Mineral distributions at the developing tendon enthesis. PLoS One 2012; 7: e48630 https://doi.org/10.1371/journal.pone.0048630
  6. Wopenka B, Kent A, Pasteris JD, Yoon Y, Thomopoulos S. The tendon-to-bone transition of the rotator cuff: a preliminary Raman spectroscopic study documenting the gradual mineralization across the insertion in rat tissue samples. 2008; 62: 1285-1294 https://doi.org/10.1366/000370208786822179
  7. Rossetti L, Kuntz LA, Kunold E, Schock J, Muller KW, Grabmayr H, et al. The microstructure and micromechanics of the tendon-bone insertion. Nat Mater 2017; 16: 664-670 https://doi.org/10.1038/nmat4863
  8. Lu HH, Subramony SD, Boushell MK, Zhang X. Tissue engineering strategies for the regeneration of orthopedic interfaces. Ann Biomed Eng 2010; 38: 2142-2154 https://doi.org/10.1007/s10439-010-0046-y
  9. Lipner J, Shen H, Cavinatto L, Liu W, Havlioglu N, Xia Y, et al. In Vivo Evaluation of Adipose-Derived Stromal Cells Delivered with a Nanofiber Scaffold for Tendon-toBone Repair. Tissue Eng Part A 2015; 21: 2766-2774 https://doi.org/10.1089/ten.tea.2015.0101
  10. Harryman 2nd DT, Mack LA, Wang KY, Jackins SE, Richardson ML, Matsen 3rd FA. Repairs of the rotator cuff. Correlation of functional results with integrity of the cuff. J Bone Joint Surg Am 1991; 73: 982-989 https://doi.org/10.2106/00004623-199173070-00004
  11. Lu HH, Thomopoulos S. Functional attachment of soft tissues to bone: development, healing, and tissue engineering. Annu Rev Biomed Eng 2013; 15: 201-226 https://doi.org/10.1146/annurev-bioeng-071910-124656
  12. Liu W, Lipner J, Xie J, Manning CN, Thomopoulos S, Xia Y. Nanofiber scaffolds with gradients in mineral content for spatial control of osteogenesis. ACS Appl Mater Interfaces 2014; 6: 2842-2849 https://doi.org/10.1021/am405418g
  13. Zhang X, Bogdanowicz D, Erisken C, Lee NM, Lu HH. Biomimetic scaffold design for functional and integrative tendon repair. J Shoulder Elbow Surg 2012; 21: 266-277 https://doi.org/10.1016/j.jse.2011.11.016
  14. Benjamin M, Evans EJ, Copp L. The histology of tendon attachments to bone in man. J Anat 1986; 149: 89-100
  15. Benjamin M, Kumai T, Milz S, Boszczyk BM, Boszczyk AA, Ralphs JR. The skeletal attachment of tendons--tendon "entheses". Comp Biochem Physiol A Mol Integr Physiol 2002; 133: 931-945 https://doi.org/10.1016/S1095-6433(02)00138-1
  16. Blevins FT, Djurasovic M, Flatow EL, Vogel KG. Biology of the rotator cuff tendon. Orthop Clin North Am 1997; 28: 1-16 https://doi.org/10.1016/s0030-5898(05)70260-1
  17. Kumagai J, Sarkar K, Uhthoff HK, Okawara Y, Ooshima A. Immunohistochemical distribution of type I, II and III collagens in the rabbit supraspinatus tendon insertion. J Anat 1994; 185: 279-284
  18. Thomopoulos S, Williams GR, Gimbel JA, Favata M, Soslowsky LJ. Variations of biomechanical, structural, and compositional properties along the tendon to bone insertion site. J Orthop Res 2003; 21: 413-419 https://doi.org/10.1016/S0736-0266(03)00057-3
  19. Moffat KL, Sun WH, Pena PE, Chahine NO, Doty SB, Ateshian GA, et al. Characterization of the structure-function relationship at the ligament-to-bone interface. Proc Natl Acad Sci U S A 2008; 105: 7947-7952 https://doi.org/10.1073/pnas.0712150105
  20. Woo SL, Gomez MA, Seguchi Y, Endo CM, Akeson WH. Measurement of mechanical properties of ligament substance from a bone-ligament-bone preparation. J Orthop Res 1983; 1: 22-29 https://doi.org/10.1002/jor.1100010104
  21. Lu HH, Jiang J. Interface tissue engineering and the formulation of multiple-tissue systems. Adv Biochem Eng Biotechnol. 2006; 102: 91-111
  22. Dormer NH, Berkland CJ, Detamore MS. Emerging techniques in stratified designs and continuous gradients for tissue engineering of interfaces. Ann Biomed Eng 2010; 38: 2121-2141 https://doi.org/10.1007/s10439-010-0033-3
  23. Lipner J, Liu W, Liu Y, Boyle J, Genin GM, Xia Y, Thomopoulos S. The mechanics of PLGA nanofiber scaffolds with biomimetic gradients in mineral for tendon-to-bone repair. J Mech Behav Biomed Mater 2014; 40: 59-68 https://doi.org/10.1016/j.jmbbm.2014.08.002
  24. Hu Y, Birman V, Deymier-Black A, Schwartz AG, Thomopoulos S, Genin GM. Stochastic interdigitation as a toughening mechanism at the interface between tendon and bone. Biophys J 2015; 108: 431-437 https://doi.org/10.1016/j.bpj.2014.09.049
  25. Kim H, Jung G, Yoon J, Han J, Park Y, Kim D, et al. Preparation and characterization of nano-sized hydroxyapatite/alginate/chitosan composite scaffolds for bone tissue engineering. Mater Sci Eng C Mater Biol Appln 2015; 54: 20-25 https://doi.org/10.1016/j.msec.2015.04.033
  26. Screen HRC, Lee DA, Bader DL, Shelton JC. An investigation into the effects of the hierarchical structure of tendon fascicles on micromechanical properties. Proc Inst Mech Eng H 2004; 218: 109-119
  27. Zhu C, Pongkitwitoon S, Qiu J, Thomopoulos S, Xia Y. Design and Fabrication of a Hierarchically Structured Scaffold for Tendon-to-Bone Repair. Adv Mater 2018; 30: e17073063