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Cellmed Orthocellular Medicine and Pharmaceutical Association (셀메드 세포교정의약학회)
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MEDICINAL BENEFITS OF ADHATODA VASICA NEES.-IN UNANI AND CONTEMPORARY MEDICINE

  • Khan, Rabia (Dept. of Moalejat, School of Unani Medical Education and Research) ;
  • Shamsi, Yasmeen (Dept. of Moalejat, School of Unani Medical Education and Research) ;
  • Nikhat, Sadia (Dept. of Ilaj bit Tadbeer, School of Unani Medical Education and Research)
  • Received : 2020.02.10
  • Accepted : 2020.03.20
  • Published : 2020.05.29
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Abstract

Arusa (Adhatoda vasica) is an important medicinal plant widely used in Unani system of medicine of (Family-Acanthaceae). The leaves of Adhatoda vasica contain several biologically active phytochemicals such as alkaloids, tannins, saponins, phenolics and flavonoids. It mainly consists of pyrroquinazoline, alkaloids, viz. vasicine, vasicol, vasicinone, peganine along with other minor constituents. The plant possesses diverse pharmacological activities, In Unani system of medicine, the drug is described as having dafa-e-tashannuj (anti-spasmodic), qatil-e-jarasim (antibiotic), mukhrij-e-balgham (expectorant), dafa-e-humma (antipyretic) properties due to which it is prescribed in a wide range of ailments like influenza, tuberculosis, bronchitis, gastric ulcers etc. Leaf juice is beneficial in the treatment of dysentery and diarrhoea. Various other activities like radio modulation, hypoglycaemic effect, cardiovascular protection, antitubercular, antiviral, hepatoprotective and antioxidant activity have also been reported.

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References

  1. Ahmad S, Madhukar G, Maksood A, Mhaveer S, Tanwir AM, Husain AS. A Phytochemical Overview On Aadhatoda Zyelanica Medica A Vasica(Linn.) Nees. Natural Product Radiance. 2009; 8(5):549-554
  2. Alam G, Singh MP, Singh A. Wound Healing Potential of some Medicinal Plants. International Journal of Pharmaceutical Sciences Review and Research. 2011;9(1):137-143.
  3. Ali M. Text book of Pharmacognosy (2nd ed). (New Delhi: CBS), 1998
  4. Anonymous. Medicinal Plants in Folklores of Orrisa. (New Delhi: CCRUM). 2006
  5. Arunachalam KD. Investigations on the phytochemical activities and wound healing properties of Adhatoda vasica leave in Swiss albino mice. African Journal of Plant Science. 2011;5: (2):133-145.
  6. Bhargava MK, Singh H, Kumar A. Evaluation of adhatoda vasica as wound healing agent in buffaloes. Clinical, Mechanical and Biochemical studies. Indian Veterinary Journal. 1988;65(1):33.
  7. Bhattacharyya D, Pandit S, Jana U, Sen S, Sur TK. Hepatoprotective activity of Adhatoda vasica aqueous leaf extract on D-galactosamine-induced liver damage in rats. Fitoterapia. 2005;76(5):10-14.
  8. Chandhoke N. Vasicine, the alkaloid of Adhatoda vasica. Indian Drugs. 1982;24:425-426.
  9. Chaturvedi GN, Rai NP, Dhani R, Tiwari SK. Clinical trial of Adhatoda vasica syrup (vasa) in patients of non-ulcer dyspepsia(Amlapitta). Ancient Science Of Life. 1983;3(1):19.
  10. Chauhan PK, Jaryal M, Saxena S, Kanishak. Antioxidant and Antimicrobial Activity of Adhatoda vasica against the bacteria isolated from the sputum samples of the asthmatic patients. International Journal of Drug Research and Technology. 2012;2(3):273-278.
  11. Claeson UP, Malmfors T, Wikman G, Bruhn JG. Adhatoda vasica: a critical review of ethnopharmacological and toxicological data. Journal of ethnopharmacology. 2000;72(1-2):1-3. https://doi.org/10.1016/S0378-8741(00)00225-7
  12. Dhar ML, Dhar MM, Dhawan BN, Mehrotra BN, Ray C. Screening of Indian Plants for Biological Activity : I. Indian Journal Of Experimental Biology. 1968;6(4):232-247.
  13. Dhuley JN. Antitussive effect of adhatoda vasica extracts on mechanical and chemical stimulation-l induced coughing in animals. J Ethnopharmacol. 1999;67(3):361-65. https://doi.org/10.1016/S0378-8741(99)00074-4
  14. Dorsch W, Wanger H. New antiasthmatics drugs from traditional Medicine? Int Arch Allergy Appl Immunol. 1991;94(1-4):262-5. https://doi.org/10.1159/000235378
  15. Gangwar KA, Ghosh KA. Medicinal uses and Pharmacological activity of Adhatoda vasica. International Journal of Herbal Medicine. pp.88-91, 2014
  16. Gao H, Huang YN, Gao B, Li P, Inagaki C, Kawabata J. Inhibitory effect on ${\alpha}$-glucosidase by Adhatoda vasica Nees.Food Chem. 2008;108(3):965-72 https://doi.org/10.1016/j.foodchem.2007.12.002
  17. George M, Venkatraman PR, Pandalai KM. Investigation Plant Atibiotics part 2 .A search for antibiotic substances in some Indian Medicinal Plants. J Sci Ind Res B. 1947;42-46.
  18. Grange JM, Snell NJ. Activity of bromhexine and ambroxol, semi synthetic derivatives of vasicine from Indian shrub Adhatoda Vasica, against Mycobacterium tuberculosis in vitro. J Ethnopharmacol. 1996;50(1):49-53. https://doi.org/10.1016/0378-8741(95)01331-8
  19. Gulfarz M, Ahmad A, Asad MJ, Sadiq A, Afzal U, Imran M, Anwar P, Zeenat A, Abbasi KS, Maqsood S, Qureshi RU. Antidiabetic activities of leaves and root extract of Justica Adhatoda Linn against alloxan induced diabetes in rats. African Journal of Biotechnology. 2011;10(32):6011-6013.
  20. Gupta AK, Ahirwar NK, Shinde N, Choudhary M, Rajput YS, Singh A. Phytochemical Screening and Antimicrobial Assessment of Leaves of Adhatoda vasica, Azadirachta indica and Datura stramonium. UK Journal of Pharmaceutical and Biosciences Journal. 2013;1(1):40-47.
  21. Gupta OP, Anand KK, Ghatak BJ, Atal CK. Vasicine, alkaloid of Adhatoda vasica, a promising uterotonic abortifacient. Indian J Exp Biol. 1978;16(10):1075-7.
  22. Gupta R, Thakur B, Singh P, Singh HB, Sharma VD, Katoch VM, Chauhan SV. Anti-tuberculosis activity of selected medicinal plants against multidrug resistant Mycobacterium tuberculosis isolates. Indian J Med Res. 2010;131:809-13.
  23. Hakeem MA. Bustan ul Mufridaat. (New Delhi: Zafar book depot), 1999
  24. Hiremath GI, AHN Y, KIM S. Insecticidal Activity of Indian Plant Extracts against Nilaparvata lugens (Homoptera: Delphacidae). Applied Entomology and Zoology. 1997;32(1):159-166. https://doi.org/10.1303/aez.32.159
  25. Iyengar MA, Jambaiah KM, Kamath MS, Rao MN. Studies on an antiasthma kada: A propriety herbal combination. Part1: Clinical study. Indian Drugs. 1994;31(5):183-186.
  26. Kabiruddin. Mukhzanul Mufradat. (Lahore: Sheikh Mohd Basheer and Sons.), pp.116-117, 1996
  27. Karthikeyan A, Shanthi V, Nagasathaya A. Preliminary phytochemical and antibacterial screening of crude extract of the leaf of Adhatoda vasica. L. International Journal of Green Pharmacy. 2009;3(1):78. https://doi.org/10.4103/0973-8258.49381
  28. Khan MA. Muheet e Azam (urdu translation). (New Delhi: CCRUM), 2014
  29. Lahiri PK, Pradhan SN. Pharmacoogical investigation of vasicinol-an alkaloid from Adhatoda vasica. Nees. Indian Journal Of Experimental Biology, 1964;2;219-222.
  30. Lyengar MA, Jambaiah KM, Kamath MS, Rao GO. A Proprietary Herbal Combination. Indian Drugs. 1994;183-186.
  31. Madak AT, Rao R. Hypoglycemic activity of anon nitrogenous principle from the leaves of Adhatoda vasica.Indian Journal Of Pharmacy. 1996; 105-106.
  32. Maurya S, Singh D. Quantitative Analysis of Total Phenolic Content in Adhatoda vasica Nees Extracts. International Journal of PharmTech Research. 2010;2(4):2403-2405.
  33. Narimanian M, Badalyan M, Panosyan V, Gabrielyan E, Panossian A, Wikman G, Wagner H. Randomized trial of a fixed combination (KanJang) of herbal extracts containing Adhatoda vasica, Echinacea purpurea and Eleutherococcus senticosus in patients with upper respiratory tract infections. Phytomedicine. 2005;12(8):539-47. https://doi.org/10.1016/j.phymed.2004.10.001
  34. Nath D, Sethi N, Singh RK, Jain AK. Commonly used Indian abortifacient plants with special reference to their teratological effects in rats. J Ethnopharmacol. 1992;36(2):147-54. https://doi.org/10.1016/0378-8741(92)90015-J
  35. Pahwa GS, Zutshi U, Atal CK. Chronic toxicity studies with Vasicine from Adhatoda vasica Nees in rats and monkeys. Indian J Exp Biol. 1987;25(7):467-70
  36. Pandita K1, Bhatia MS, Thappa RK, Agarwal SG, Dhar KL, Atal CK. Seasonal variation of alkaloid of adhatoda vasica and detection of glycosides and N oxides of vasicine and vasicnonei. Planta Med. 1983;48(2):81-2. https://doi.org/10.1055/s-2007-969891
  37. Parrotta JA. Healing plants of Peninsular India. (New York: CABI), 2001
  38. Patel VK, Venkatakrishna-Bhatt H. In vitro study of antimicrobial activity of Adhatoda Vasika Linn. (leaf extract) on gingival inflammation--a preliminary report. Indian J Med Sci. 1984;38(4):70-2.
  39. Prathiba M, Giri R. Pharmacognostic Study on Adhatoda vasica En. Asian journal of Innovative Research, 2018;3(1):48-54.
  40. Purohit AP, Gokhale SB. Pharmacognosys (2nd ed.). (Punr: Nirali prakashan), 2003
  41. Rabinivich MI, Leskov AI, Gladikikh AS. Cholegogic properties of Peganine. Vrachei, pp. 181, 1996
  42. Rastogi RP, Mehrotra BN. Compendium of Indian Medicinal Plant. (Lucknow: Central Drug Research Institute of Lucknow and National Institute of Science Communication), 1990
  43. Roy CD, Shaik MM, Munnan M, Faruqee, & Md, H. A brief review on phytochemistry and pharmacological properties of Adhatoda vasica. Journal of Tropical Medicinal Plants. 2013;14:115-124.
  44. Saxena BP, Tikku K, Atal CK. Insect antifertility and antifeedant allelochemicals in Adhatoda vasica. Insect sci Appl. 1986; 489.
  45. Shahwar D, Raza MA, Triq S, Riasat M, Ajaib M. Enzyme inhibition, antioxidant and antibacterial potential of vasicine. Pak. J. Pharm. Sci. 2012; 25:651-656.
  46. Shriivastava N, Srivastava A, Banerjee A, Nivasarkar M. Anti ulcer activity of Adhatoda vasica. Journal of Herbal Pharmacotherapy. 2006; 43-49.
  47. Shrivastava N, Shrivastava A, Banarjee A, Nivsarkar M. Anti-Ulcer Activity of Adhatoda vasica Nees. Journal of Herbal Pharmacotherapy. 2009;6(2):43-49. https://doi.org/10.1080/J157v06n02_04
  48. Srinivasan K, Sivasubramanian S, Kumaravel S. Phytochemical profiling and GCMS Study of Adhatoda vasica Leaves. International Journal Of Pharma and bioscience. 2014
  49. United State Department of Agriculture. Classification for Kingdom Plantae Down to Species Justicia adhatoda L., 2013. Available at: http://www.plants.usda.gov/java/Classification (accessed on 25th October, 2019)
  50. Usmanghani K, Saeed A, Alam MT. Traditional Medicine of Herbal, Animal and Mineral Origin in Pakistan. (Karachi: Indusyunic Medicine), 1997
  51. Vinothapooshan G, Sundar K. Wound healing effect of various extracts of Adhatoda vasica. International Journal of Pharma and Bio Sciences. 2010;530-535.
  52. Zama MM, Singh HP, Kumar A. Comparative studies on wound healing in buffaloes. Indian Vet J. 1991;864-866.