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Effects of Dual-Task Training with Cognitive Tasks on Cognitive Function and β-amyloid Levels in the Elderly with Mild Dementia

  • Received : 2020.02.20
  • Accepted : 2020.03.25
  • Published : 2020.05.31

Abstract

PURPOSE: The purpose of this study was to examine the effects of dual-task training with cognitive tasks on cognitive functions and β-amyloid levels in the elderly with mild dementia. METHODS: The subjects were 36 elderly inpatients diagnosed with mild dementia at S Hospital located in Gyeongsangbuk-do, South Korea. The patients were randomly divided into a dual-task training group (DTG; n = 18) or a single-task training group (STG; n = 18). DTG performed dual-task training with cognitive tasks while STG performed only exercise tasks. These groups performed their respective exercises during a 30-minute session occurring three times a week over an 8-week period. MMSE-K and GDS were used to measure the subjects' cognitive function. To assess the subjects' dementia-related factors, their β-amyloid levels were measured by blood analysis. RESULTS: The results of the experiment were as follows: DTG showed statistically significant differences between their MMSE-K scores and β-amyloid levels before and after training (p < .05), whereas they exhibited no statistically significant differences in their GDS scores. MMSE-K scores and β-amyloid levels were significantly different between DTG and STG after training. CONCLUSION: The present study's overall results indicate that dual-task training with cognitive tasks is more effective than single-task training in improving cognitive functions and β-amyloid levels in the elderly with mild dementia. In other words, regular dual-task training can be considered as effective in improving cognitive function and dementia-related factors in the elderly with mild dementia and thus may be suggested as an effective exercise method for the treatment and early prevention of dementia.

Keywords

References

  1. McDowell I. Alzheimer's disease: insights from epidemiology. Aging Clin Exp Res. 2001;13(3):143-62. https://doi.org/10.1007/BF03351474
  2. Ritchie K, Lovestone S. The dementias. The Lancet. 2002;360(9347):1759-66. https://doi.org/10.1016/S0140-6736(02)11667-9
  3. Borroni B, Colciaghi F, Archetti S, et al. Predicting cognitive decline in Alzheimer disease: Role of platelet amyloid precursor protein. Alz Dis Assoc Dis. 2004;18(1):32-4. https://doi.org/10.1097/00002093-200401000-00006
  4. Pietrzik C, Behl C. Concepts for the treatment of Alzheimer's disease: molecular mechanisms and clinical application. Int J Exp Pathol. 2005;86(3):173-85. https://doi.org/10.1111/j.0959-9673.2005.00435.x
  5. Thomas VS, Hageman PA. A preliminary study on the reliability of physical performance measures in older day-care center clients with dementia. Int Psychoger. 2002;14(1):17-23. https://doi.org/10.1017/S1041610202008244
  6. Fratiglioni L, Launer LJ, Andersen K, et al. Incidence of dementia and major subtypes in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group. Neurology. 2000;54(11 Suppl 5):10-5
  7. Olazaran J, Reisberg B, Clare L, et al. Nonpharmacological therapies in Alzheimer's disease: a systematic review of efficacy. Dement Geriatr Cogn Disord. 2010;30(2):161-78. https://doi.org/10.1159/000316119
  8. Barnes DE, Yaffe K, Satariano WA, et al. A longitudinal study of cardiorespiratory fitness and cognitive function in healthy older adults. J Am Geriatr Soc. 2003;51(4):459-65. https://doi.org/10.1046/j.1532-5415.2003.51153.x
  9. Gates N, Singh MAF, Sachdev PS, et al. The effect of exercise training on cognitive function in older adults with mild cognitive impairment: a meta-analysis of randomized controlled trials. Am J Geriatr Psychiatry. 2013;21(11):1086-97. https://doi.org/10.1016/j.jagp.2013.02.018
  10. Forkan R, Pumper B, Smyth N, et al. Exercise adherence following physical therapy intervention in older adults with impaired balance. Phys Ther. 2006;86(3):401-10. https://doi.org/10.1093/ptj/86.3.401
  11. Holtzer R, Mahoney JR, Izzetoglu M, et al. fNIRS study of walking and walking while talking in young and old individuals. J Gerontol A Biol Sci Med Sci. 2001;66(8):879-87.
  12. Woollacott M, Shumway-Cook A. Attention and the control of posture and gait: a review of an emerging area of research. Gait Posture. 2002;16(1):1-14. https://doi.org/10.1016/S0966-6362(01)00156-4
  13. Yang YR, Chen YC. Lee CS, et al. Dual-task-related gait changes in individuals with stroke. Gait Posture. 2007;25(2):185-90. https://doi.org/10.1016/j.gaitpost.2006.03.007
  14. O'Shea S, Morris ME, Iansek R. Dual task interference during gait in people with Parkinson disease: effects of motor versus cognitive secondary tasks. Phys Ther. 2002;82(9):888-97. https://doi.org/10.1093/ptj/82.9.888
  15. Dean CM, Richards CL, Malouin F. Task-related circuit training improves performance of locomotor tasks in chronic stroke: a randomized, controlled pilot trial. Arch Phys Med Rehabil. 2000;81(4):409-17. https://doi.org/10.1053/mr.2000.3839
  16. Hollman JH, Kovash FM, Kubik JJ, et al. Age-related differences in spatiotemporal markers of gait stability during dual task walking. Gait Posture. 2007;26(1):113-9. https://doi.org/10.1016/j.gaitpost.2006.08.005
  17. Pellecchia GL. Dual-task training reduces impact of cognitive task on postural sway. J Mot Behav. 2005;37(3):239-46. https://doi.org/10.3200/JMBR.37.3.239-246
  18. Kwon YC. Korean version of mini-mental state examination (MMSE-K). J Korean Neurol Assoc. 1989;1:123-35.
  19. Kang Y, Na DL, Hahn S. A validity study on the Korean Mini-Mental State Examination (K-MMSE) in dementia patients. J Korean Neurol Assoc. 1997;15(2):300.
  20. Choi SH, Na DL, Lee BH, et al. The validity of the Korean version of Global Deterioration Scale. J Korean Neurol Assoc. 2002;20(6):612.
  21. Park KS, Jeong HY, So SY, et al. The effects of the activity program for preventing dementia against depression, cognitive function, and quality of life for the elderly. JON. 2013;24(4):353-62.
  22. Kim K, Kim O. The effects of exercise-cognitive combined dual-task program on cognitive function and depression in elderly with mild cognitive impairment. Korean J Adult Nurs. 2015;27(6):707-17. https://doi.org/10.7475/kjan.2015.27.6.707
  23. You JH, Shetty A, Jones T, et al. Effects of dual-task cognitive-gait intervention on memory and gait dynamics in older adults with a history of falls: a preliminary investigation. NeuroRehabilitation. 2009;24(2):193-8. https://doi.org/10.3233/NRE-2009-0468
  24. Silsupadol P, Siu KC, Shumway-Cook A, et al. Training of balance under single-and dual-task conditions in older adults with balance impairment. Phys Ther. 2006;86(2):269-81. https://doi.org/10.1093/ptj/86.2.269
  25. Michel JA, Mateer CA. Attention rehabilitation following stroke and traumatic brain injury: a review. Eur J Phys Rehabil Med. 2006;42(1):59.
  26. Netz Y, Jacob T. Exercise and the psychological state of institutionalized elderly: a review. Percept Mot Skills. 1994;79(3):1107-18. https://doi.org/10.2466/pms.1994.79.3.1107
  27. Yokoyama H, Okazaki K, Imai D, et al. The effect of cognitive-motor dual-task training on cognitive function and plasma amyloid ${\beta}$ peptide 42/40 ratio in healthy elderly persons: a randomized controlled trial. BMC Geriatr. 2015;15(1):60. https://doi.org/10.1186/s12877-015-0058-4
  28. Hwang JH. The effect of dual task-virtual reality program on the cognitive function, balance and EEG for seniors with mild cognitive impairment. Doctor's Degree. Daegu University. 2017.
  29. Erickson KI, Colcombe SJ, Wadhwa R, et al. Traininginduced functional activation changes in dual-task processing: an FMRI study. Cereb Cortex, 2006;17(1):192-204. https://doi.org/10.1093/cercor/bhj137