Journal of Acupuncture Research

  • 제37권2호
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  • Pages.102-109
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  • 2020
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  • 2586-288X(pISSN)
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  • 2586-2898(eISSN)
대한침구의학회 (Korean Acupuncture & Moxibustion Medicine Society)
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Clinical Efficacy and Safety of Gyebutang Granules Combined with Acupuncture for the Treatment of Knee Osteoarthritis: Protocol for a Multicenter, Randomized, Assessor-blinded, 2-armed Parallel, Controlled Trial

  • Lee, Cham-Kyul (Department of Acupuncture & Moxibustion, Semyung University Korean Medicine Hospital) ;
  • Kang, Ha-Ra (Department of Korean Medicine, Dongguk University Graduate School) ;
  • Lee, Yeon-Sun (Department of Acupuncture & Moxibustion, Dongguk University Ilsan Oriental Hospital) ;
  • Sung, Won-Suk (Department of Acupuncture & Moxibustion, Dongguk University Bundang Oriental Hospital) ;
  • Lim, Chi-Yeon (Department of Biostatistics, School of Medicine, Dongguk University) ;
  • Jung, Chan-Yung (Department of Acupuncture & Moxibustion, Dongguk University Ilsan Oriental Hospital) ;
  • Kim, Eun-Jung (Department of Acupuncture & Moxibustion, Dongguk University Bundang Oriental Hospital) ;
  • Seo, Byung-Kwan (Department of Acupuncture & Moxibustion, College of Korean Medicine, Kyung Hee University) ;
  • Baek, Yong-Hyeon (Department of Acupuncture & Moxibustion, College of Korean Medicine, Kyung Hee University) ;
  • Kim, Kyung-Ho (Department of Acupuncture & Moxibustion, Dongguk University Ilsan Oriental Hospital) ;
  • Lee, Eun-Young (Department of Acupuncture & Moxibustion, Semyung University Korean Medicine Hospital)
  • 투고 : 2020.01.21
  • 심사 : 2020.04.28
  • 발행 : 2020.05.31
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초록

Background: Due to the aging population in Korea, knee osteoarthritis (KOA) has become an increasingly common condition. Many patients with KOA prefer analgesics, herbal medicines, acupuncture, or exercise, rather than arthroscopic surgery or a knee replacement. Gyebutang (GB) granules are a herbal extract widely used to treat KOA in traditional Korean medicine, but there is insufficient evidence of its efficacy and safety. Methods: A multicenter, randomized, assessor-blinded, 2-armed parallel, controlled clinical trial has been designed to investigate the efficacy and safety of GB combined with acupuncture for the treatment of KOA. There will be 100 patients with KOA enrolled in the study from 3 traditional Korean medicine hospitals. The participants will be randomly allocated to an experimental group (GB and acupuncture) or a control group (celecoxib and acupuncture) in a 1:1 ratio. Both groups will receive acupuncture treatment once a week for 6 weeks; one group will receive GB and the other will receive celecoxib for the same duration. Results: The primary outcome will be the change of knee osteoarthritic pain, based on scores on a 100 mm visual analog scale. The secondary outcomes will be scores on a numeric rating scale, the Western Ontario and McMaster Universities osteoarthritis index, patient global assessment, European quality of life 5-dimension 5-level scale, and adverse events. Conclusion: The results of this study will provide evidence of efficacy and safety of GB as a treatment for patients with KOA.

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