Neonatal Medicine

The Korean Society of Neonatology (대한신생아학회)
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Successful Treatment of Mycoplasma hominis Meningitis, Diagnosed Using Real-Time Polymerase Chain Reaction, with Ciprofloxacin in a Neonate

  • Gwon, Iktae (Department of Pediatrics, Daejeon Eulji Medical Center) ;
  • Song, Woo Sun (Department of Pediatrics, Daejeon Eulji Medical Center) ;
  • Sohn, Yong-Hak (Department of Laboratory Medicine, Seegene Medical Foundation) ;
  • Kim, Seung Yeon (Department of Pediatrics, Daejeon Eulji Medical Center)
  • Received : 2020.05.06
  • Accepted : 2020.06.25
  • Published : 2020.08.31
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Abstract

Mycoplasma hominis can cause life-threatening central nervous system infections in neonates following intrauterine infection or during delivery. In newborns, the diagnosis and treatment of M. hominis meningitis are challenging, because cultures are often negative and the bacterium is not susceptible to empirical antibiotics. Herein, we describe a case of neonatal M. hominis meningitis diagnosed using real-time polymerase chain reaction (RT-PCR) and treated with ciprofloxacin. The patient was a 3-day-old female hospitalized for a fever and lethargy. Her blood laboratory findings were non-specific; cerebrospinal fluid (CSF) examination showed a white blood cell count of 580/μL and indicated meningitis. Her symptoms could not be controlled with empirical antibiotics. Urine culture on a special medium revealed ciprofloxacin-susceptible M. hominis. Furthermore, the RT-PCR performed with the CSF sample revealed M. hominis. Therefore, the patient was administered ciprofloxacin; after 2 days, the fever subsided. The patient was discharged on day 30 without complications.

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References

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