The Journal of Korean Obstetrics and Gynecology (대한한방부인과학회지)

The Society of Korean Medicine Obstetrics and Gynecology (대한한방부인과학회)
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A Literature Review on the Recent Tendency of the Treatment about Atypical Hyperplasia of Breast on the Chinese Herbal Medicine

비정형유방증식에 대한 최근 중의 약물치료 동향에 대한 문헌연구

  • Kim, Jun-Hee (Dept. of Korean Medicine, Graduate School, Dong-Eui University) ;
  • Lee, In-Seon (Dept. of OB & GY, College of Oriental Medicine, Dong-Eui University)
  • 김준희 (동의대학교 대학원 한의학과) ;
  • 이인선 (동의대학교 한의과대학 부인과교실)
  • Received : 2020.01.09
  • Accepted : 2020.02.28
  • Published : 2020.02.28
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Abstract

Objectives: We conducted a literature study on the treatment trends in China to find out the possibility of Oriental medicine treatment of atypical hyperplasia of breast (AHB). Methods: RCTs (randomized controlled trial) on AHB were collected from CNKI (China National Knowledge Infrastructure). The search words were "乳腺增生", "乳腺囊性增生", "乳癖", "中医", "中药" and "中西医结合". The search period was limited from July 2006 to May 2017. Finally, we selected 107 RCTs which were clinical studies to find out the effectiveness of Chinese herbal medicine in comparison with Western medicine. After reviewing, we investigated Chinese herbal medication guide, Chinese treatment method and prescriptions. And the correlation between the treatments and the medicinal herbs was investigated to be useful in the clinical practice. Results: 1. The administration of herbal medicine was 58.9 percent in 63 cases, followed by menstrual cycles, and 41.1 percent in 44 cases, regardless of menstrual cycles. 2. In the basic frequency analysis between the treatment and the medicinal herb, the frequency of dissipate binds (散結) was the highest. Next, there was a high frequency of therapies such as activating blood-activating (活血), relieve pain (止痛), soothe the liver (疏肝), regulate qi (理氣), resolve phlegm (化痰), soften hardness (軟堅), resolve depression (解鬱), move qi (行氣) of frequency was high. In herbal medicine, bupleuri radix (柴胡), cyperi rhizoma (香附子), angelicae gigantis radix (當歸), fritillaria thunbergii bulb (貝母), paeoniae radix alba (白芍藥), prunellae spica (夏枯草), corydalis rhizoma (玄胡索) showed high frequency. 3. We finded out the correlation between the frequent treatment methods and the medicinal herbs using Text Mining. Conclusions: These findings are thought to help implement Korean traditional medicine treatments for AHB.

Keywords

References

  1. Bae JG. The Breast of Oriental Medicine. Seoul:Jungdam. 2005:245-50.
  2. Liang XL, Wang L. Treatment of breast hyperplasia with traditional Chinese and Western Medicine. Chinese J. of Ethnomedicine and Ethnopharmacy. 2016;25(19):75-9.
  3. Lei QM, Hu YC. Clinical observation of Rutonghesan granule No.3 in the Treatment of Breast hyperplasia of Chong Ren disorder type. Shanxi Traditional Chinese Medicine. 2010;26(10):13-5.
  4. Shi XC, Zhou SP. Clinical Research on Mammary Hyperplasia Treated with Integrated Chinese and Western Medicine, World J. of Integrated Traditional and Western Medicine. 2010;5(12):1061-3.
  5. Du Yanni. 62 cases of Mammary hyperplasia treated by Chinese and Western Medicine. Chinese Medicine Modern Distance Education of China. 2011;9(18):53-4.
  6. Park SH. The Breast Cancer White Paper. Korea Breast Society. 2018:7-11.
  7. Wang GF. Experience in the treatment of mammary hyperplasia with the combination of Chinese and Western Medicine. J. of Practical Medical Techniques. 2007;14(33):4619-20.
  8. Huang Q. A Clinical study of Rupixiao pill combined with tamoxifen in the treatment of breast hyperplasia. Chinese J. of Modern Drug Application. 2016;10(23):145-6.
  9. Zhou Y. Therapeutic Effect of Tamoxifen and Chinese Traditional Patent Medicine on Breast Hyperplasia. Practical Pharmacy And Clinical Remedies. 2007;10(3):138-9.
  10. Zhang KR. Observation on the therapeutic effect of Xuefu Zhuyu Decoction in the treatment of 40 cases of mammary hyperplasia. Clinical medicine research and Practice. 2016;1(22):117-8.
  11. Wang Y. Clinical observation of Hongjin Xiaojie capsule in the treatment of 130 cases breast hyperplasia. China Medical Herald. 2008;5(20):94-5.
  12. Chen MY, Jiang DQ. Application of Hongjin Xiaojie capsule in breast hyperplasia. Clinical J. of traditional Chinese Medicine. 2017;29(7):1126-9.
  13. Liu JH. Comparison of therapeutic effect between Xiaojiean capsule and tamoxifen in the treatment of breast hyperplasia. J. of practical Gynecological Endocrinology (Electronic Edition). 2015;2(6):94-5.
  14. Guo JF, et al. Observation on the curative effect of combined traditional Chinese and Western Medicine on hyperplasia of mammary gland. Modern J. of Integrated Traditional Chinese and Western Medicine. 2013;22(14):1504-6.
  15. Xu JJ, Qiu ZL. Rukuaixiao granules in the treatment of hyperplasia of mammary gland. Chinese J. of Traditional Medical Science and Technology. 2015;22(6):696-7.
  16. Wu MY. Meta analysis of the treatment of breast hyperplasia with the combination of Chinese and Western medicine. Guangming traditional Chinese Medicine. 2013;28(7):1437-9.
  17. Liao MJ, et al. A Meta analysis of randomized controlled trials of traditional Chinese medicine in the treatment of breast hyperplasia. Chinese Journal of traditional Chinese medicine information. 2010;17(10):17-20.
  18. Li R. A Meta analysis OF Tamoxifen combined with Chinese patent medicine in the treatment of breast hyperplasia. Chinese medical innovation. 2013;10(20):143-5.
  19. Kang CW, Jo JS, Choi SB. Introduction to big data analysis using R and RStudio. Paju:free Academy. 2018.
  20. Heo MH. Introduction to Social Network Analysis Using R. Paju:free Academy. 2012.
  21. Renganathan, Vinaitheerthan. "Text Mining in Biomedical Domain with Emphasis on Document Clustering". Healthcare Informatics Research. 2017;23(3):141-6. https://doi.org/10.4258/hir.2017.23.3.141
  22. Heo MH. Data Visualization. Paju: free Academy. 2014.
  23. Ingo F, Kurt H, David M. Text Mining Infrastructure in R. J. of statistical software. 2008;25(5):1-54.
  24. Li X, Shi JY. Clinical observation on 198 cases of mammary hyperplasia treated by the combination of traditional Chinese and Western Medicine. Forum on Traditional Chinese Medicine. 2008;23(4):37-8. https://doi.org/10.3969/j.issn.1002-1078.2008.04.030
  25. Yan MD, et al. Effect of TCM Periodic Therapy in Improvement of Endocrine Hormones and Symptoms of Patients with Breast Hyperplasia and Breast Pain. Chinese Archives of Traditional Chinese Medicine. 2017;35(3):745-8.
  26. Wang XJ, et al. Kangru Sanjie Decoction for the treatment of 50 cases of breast hyperplasia. Shaanxi J. of Traditional Chinese Medicine. 2010;31(3):273-4. https://doi.org/10.3969/j.issn.1000-7369.2010.03.010
  27. Yang H. Observation on the therapeutic effect of Xiaopi Sanjie No.1 and No.2 combined therapy on mastia. Guangxi Traditional Chinese Medicine. 2007;30(4):24-5.
  28. Wang CZ. 58 cases of mammary hyperplasia treated with the combination of Chinese and Western Medicine. Traditional Chinese Medicinal Research. 2016;29(8):20-2.
  29. Su C, et al. Treatment of 87 cases of perimenopausal mammary hyperplasia by Warming Yang and resolving phlegm. Shanghai J. of traditional Chinese Medicine. 2011;45(11):69-71.
  30. Li HW. 110 Cases of Cyclomastopathy with Combined Treatment of Traditional Chinese Medicine and Western Medicine. J. of Practical Medical Techniques. 2007;5(10):146-7.
  31. Ding SJ. An analysis of 192 cases of cystic hyperplasia of breast treated with the combination of traditional Chinese and Western Medicine. J. of Modern Medicine and Health. 2007;23(10):1523-4.
  32. Guo Y. Clinical observation on the treatment of breast hyperplasia with the combination of Chinese and Western medicine. Chinese Community Doctors. 2011;(17):189-90.
  33. Liu XM, Liu QH. Clinical observation on the treatment of mammary gland hyperplasia with self-made traditional Chinese medicine. modern traditional Chinese Medicine. 2015;35(1):26-7.
  34. Bian DX, Zhang Y. Clinical observation on the treatment of mammary gland hyperplasia with Sanjie Xiaopi Decoction and Western medicine. J. of New Chinese Medicine, 2016;48(11):123-4.
  35. Li H, et al. Clinical observation on 900 cases of mammary hyperplasia treated with the combination of Chinese and Western Medicine. Chinese J. of Ethnomedicine and Ethnopharmacy. 2010;19(17):150.
  36. Wang CH, Hao LL. Clinical observation on 112 cases of mammary hyperplasia treated with traditional Chinese Medicine. Jilin J. of Chinese Medicine. 2012;32(11):1128-9.
  37. Gao ZY. Clinical experience in the treatment of mammary gland hyperplasia with the combination of traditional Chinese and Western Medicine. China Health Industry. 2012;9(14):176.
  38. Wang XX. Clinical observation on 38 cases of mammary hyperplasia treated by the combination of Chinese and Western Medicine. China Practical Medicine. 2012;9(14):176.
  39. Yang J. Clinical analysis of 78 cases of mammary hyperplasia treated by self-made Xaopiyin. Guide of China Medicine. 2012;10(1):226-7. https://doi.org/10.3969/j.issn.1671-8194.2012.01.184
  40. Xie BL, et al. The clinical effect of Xiaopitongru Decoction on 130 cases of mammary hyperplasia. J. of Practical Medical Techniques. 2011;9(18):296.
  41. Zhao RJ, Chen SL. Observation on the therapeutic effect of Cigu Sanxian Sanjia Xiaopi Decoction on 45 cases of breast hyperplasia. J. of Hebei Traditional Chinese Medicine. 2010;32(9):1311-2.
  42. Pei WJ. Clinical observation on 52 cases of mammary hyperplasia treated by the combination of Chinese and Western medicine. Inner Mongolia Medical Journal. 2010;29(4):31.
  43. Qian HD. Analysis of the curative effect of 50 cases of hyperplasia of mammary gland treated by the combination of traditional Chinese and Western medicine. Modern yangsheng. 2014;12:115.
  44. Lei QM, Hu YC. Clinical observation on the treatment of mammary hyperplasia with rutonghesan granule I. Hubei J. of traditional Chinese Medicine. 2010;32(12):42. https://doi.org/10.3969/j.issn.1000-0704.2010.12.026
  45. Zhuo R, Chai Y. Clinical Research on the Treatment of Fibrocystic Disease of Breast with TCM. J. of Liaoning University of Traditional Chinese Medicine. 2007;9(6):137-9.
  46. Chen H, Luo T. Clinical observation on 48 cases of small breast cyst treated by Xiaoji decoction. Contemporary medicine. 2009;15(28):157.
  47. Liu JH. Comparison of therapeutic effect between Xiaojiean capsule and tamoxifen in the treatment of breast hyperplasia. J. of practical Gynecological Endocrinology (Electronic Edition). 2015;2(6):94-5.
  48. Shi LJ. Observation on the curative effect of Xiaoru Decoction in the treatment of mammary hyperplasia. health of urban and rural enterprises in China. 2016;9:114-6.
  49. Hu YY, Lou LH. Clinical observation of mammary gland No.1 in the treatment of 68 cases of mammary hyperplasia. Zhejiang J. of Traditional Chinese Medicine. 2014;49(8):589.
  50. He JX. Clinical observation of haizaoxiaoliu capsule in the treatment of breast hyperplasia. Hubei J. of traditional Chinese Medicine. 2013;35(11):16-7.
  51. Liu HY. Clinical observation on the treatment of mammary hyperplasia with Xiaoyao Bailu powder. Hubei J. of traditional Chinese Medicine. 2013;35(11):46.
  52. Yi CH. Ruxiaokang in the treatment of 56 cases of breast hyperplasia. J. of North pharmacy. 2013;10(4):29-30.
  53. Ge JA. Tiaoruda Tai Fang in the treatment of 60 cases of breast hyperplasia. Hebei Traditional Chinese Medicine. 2012;34(4):522-3.
  54. Wang JY, Zhao GN, Xu W. Clinical observation on 80 cases of mammary hyperplasia treated with Rujie powder. Hebei Traditional Chinese Medicine. 2013;34(11):1612-4.
  55. Liu B. Observation of therapeutic effect of Xiaojin Pill on hyperplasia of mammary lobule. Medical theory and Practice. 2011;24(9):1053-4.
  56. Mo XQ. Clinical observation on the treatment of mammary hyperplasia with Wenyang Xiaopi decoction. Guangxi Traditional Chinese Medicine. 2010;33(2):11-2.
  57. Wang RM. Xiaopi Decoction in the treatment of 60 cases of breast hyperplasia. Chinese folk health medicine. 2008;20(13):1465.
  58. Liu Y, Pang D. Xiaojiean capsule and tamoxifen in the treatment of breast hyperplasia. J. of traditional Chinese Medicine. 2013;41(2):86-8.
  59. Jin ZX, Gu Rui XA, Huang ZY. Clinical study on 60 cases of hyperplasia of breast treated by Xiaopi formula. Henan traditional Chinese Medicine. 2009;29(9):885-6.
  60. Zhuo R, Chai Y. Clinical observation of Xiaopi formula in the treatment of breast hyperplasia. Guangxi Traditional Chinese Medicine. 2007;30(4):22-3.
  61. Jian XC. Wenshen liqi huayu Decoction in the treatment of 102 cases of breast hyperplasia. Chinese Medicine Modern Distance Education of China. 2007;30(4):22-3.
  62. Zhao SG. Clinical observation on the treatment of mammary gland hyperplasia with Jianpi Xingqi Bushen recipe. Chinese J. of Traditional Medical Science and Technology. 2012;19(1):72-3.
  63. Zhao GH. Observation on the curative effect of combined traditional Chinese and Western medicine in the treatment of mammary hyperplasia. China Modern Doctor. 2007;45(4):67-8. https://doi.org/10.3969/j.issn.1673-9701.2007.04.053
  64. Liu GX, Liu SZ. 50 cases of mammary hyperplasia treated by the combination of traditional Chinese and Western Medicine. Modern J. of Integrated Traditional Chinese and Western Medicine. 2008;17(2):207. https://doi.org/10.3969/j.issn.1008-8849.2008.02.031
  65. Liu ZH, Huang ZQ. 60 cases of chronic anal sinusitis treated with Kushen Diyu Huaijiao Decoction and Western Medicine. Practical Clinical J. of Integrated Traditional Chinese and Western Medicine. 2008;8(6):55.
  66. Bao QM. Observation on the curative effect of Rutong pill in the treatment of hyperplasia of mammary gland with pain. World latest medicine information (Electronic Edition). 2015;15(15):164.
  67. Qin H. Sanjie Xiaopi formula combined with tamoxifen citrate tablets in the treatment of 50 cases of breast hyperplasia. Traditional Chinese Medicinal Research. 2014;27(1):26-7. https://doi.org/10.3969/j.issn.1001-6910.2014.01.14
  68. Deng YF, Zhang HY, Tu TX. Study on TCM-WM Therapy for Adenosis of Mammary. Modern Medicine and Health. 2008;24(8):1134-5.
  69. Chen YH, Li ZH, Chen H. Clinical Analysis of 48 cases of Breast Hyperplasia Treated with Integrated Traditional Chinese and Western Medicine. Chinese J. of Integrated Traditional and Western Medicine. 2008;24(8):1134-5.
  70. Wang WY. Observation on the curative effect of breast hyperplasia treated by the combination of Chinese and Western Medicine. Cardio vascular Disease J. of Integrated Traditional Chinese and Western Medicine(Electronic Edition). 2015;3(18):37-8.
  71. Deng YF, Zhang HY, Tu TX. Study on TCM-WM Therapy for Adenosis of Mammary. Journal of Modern Medicine and Health. 2008;24(8):1134-5.
  72. Liu SM, Sun JY. Observation on 60 cases of breast hyperplasia treated by zhongguanchuanyijielian. Chinese J. of Integrated Traditional and Western Medicine. 2014;6(11):104-5.
  73. Luo XB. Observation on the curative effect of the treatment of mammary hyperplasia with the combination of Chinese and Western Medicine. Acta Medicinae Sinica. 2007;20(3):484-5. https://doi.org/10.3969/j.issn.1008-2409.2007.03.037
  74. Gu SQ. Clinical observation on 66 cases of mammary gland hyperplasia treated with the combination of Chinese and Western Medicine. Chinese J. of Ethno medicine and Ethno pharmacy. 2014;23(3):71.
  75. Chen CB, Lu Xue Q, Xu JX. Clinical observation on the treatment of mammary hyperplasia with the combination of traditional Chinese and Western Medicine. J. of Henan University(Medical Science). 2008;27(4):66-7. https://doi.org/10.3969/j.issn.1672-7606.2008.04.021
  76. Du YZ, Li QG. Clinical Observation on Treatment of Hyperplasia of Mammary Glands with Comblined Chinese and Western Medicine. Chinese Medicine Modern Distance Education of China. 2008;6(5):455-6. https://doi.org/10.3969/j.issn.1672-2779.2008.05.048
  77. Zheng JC. Treatment of mammary gland hyperplasia with combination of Chinese and Western Medicine. Modern J. of Integrated Traditional Chinese and Western Medicine. 2008;17(33):5160-1.
  78. Cui CL. Observation on the curative effect of 68 cases of mammary hyperplasia treated with the combination of Chinese and Western Medicine. Chinese Medicine Modern Distance Education of China. 2009;7(7):23. https://doi.org/10.3969/j.issn.1672-2779.2009.07.023
  79. Zhang YQ. Clinical observation on 389 cases of mammary hyperplasia treated with the combination of Chinese and Western Medicine. Forum on Traditional Chinese Medicine. 2008;23(4):34. https://doi.org/10.3969/j.issn.1002-1078.2008.04.027
  80. Li LL. Clinical observation on treating cyclomastopathy with TCM medicine. Chinese J. of Integrated Traditional and Western Medicine. 2015;7(35):65-7.
  81. Li YF. Observation on the curative effect of 40 cases of mammary hyperplasia treated with the combination of Chinese and Western Medicine. China's Naturopathy. 2015;23(3):59-60.
  82. Lin HM, An YF. Treatment Rupisanjie capsule combined with tamoxifen for breast hyperplasia. J. of Changchun University of Traditional Chinese Medicine. 2015;31(4):783-4. https://doi.org/10.13463/j.cnki.cczyy.2015.04.046
  83. Chen W. Observation on the curative effect of 40 cases of mammary hyperplasia treated by the combination of Chinese and Western Medicine. Chinese J. of Traditional Medical Science and Technology. 2016;23(2):243, 247.
  84. Li YS, Li JL. Observation on the therapeutic effect of Prunella vulgaris and Chaihu formula combined with anti estrogen drugs on breast hyperplasia. J of New Chinese Medicine. 2016;48(8):160-1.
  85. Huang ZY. Treatment of hyperplasia of mammary gland with Sanyu Huatan Decoction and tamoxifen. Shaanxi J. of Traditional Chinese Medicine. 2015;36(3):267-8.
  86. Wang L. Ruhe Sanjie tablet in the treatment of 65 cases of breast hyperplasia. Chinese Medicine Modern Distance Education of China. 2010;8(16):182.
  87. Wang YM, Yuan M. Clinical observation of Rujiqing mixture in the treatment of breast cystic hyperplasia. Chinese J. of traditional Chinese medicine information 2007;14(5):62.
  88. Song CW, Xing GX. Treating 60 Cases of CysticHyperplasia of Breast in the Integrative Medicine. J. of Practical Traditional Chinese Internal Medicine. 2011;25(5):99-100. https://doi.org/10.3969/j.issn.1671-7813.2011.05.56
  89. Luo XB. Observation on the curative effect of mammary gland hyperplasia treated with the combination of traditional Chinese and Western Medicine. Liuzhou Medicine. 2008;21(1):31-2.
  90. Zhou YX. 64 cases of severe hyperplasia of mammary gland treated with combination of Chinese and Western Medicine. Chinese Community Doctors. 2015;9(16):98.
  91. Cheng WH, Zhang H, Xiao LY. Clinical observation of litchi kernel granule in the treatment of breast hyperplasia. Clinical Medicine & Engineering. 2013;20(1):25-6.
  92. Liang SH, Li TG. Clinical observation of Ziyin Sanjie formula in the treatment of breast hyperplasia. Liaoning J. of traditional Chinese Medicine. 2013;40(2):281-2.
  93. Yang HY. The Combination of Traditional Chinese and Western Medicine in the Treatment of Mammary Glands Hyperplasia of Liver Depression and Hysteresis Type. J. of Changchun University of Traditional Chinese Medicine. 2014;30(3):486-8. https://doi.org/10.13463/j.cnki.cczyy.2014.03.042
  94. Zhang XG. Effect of Traditional Chinese Medicine Treatment of 56 Hyperplasia of Mammary Glands. China Health Standard Management. 2016;7(12):131-2.
  95. Lan XD, Qi L, Liu DW. Clinical study on the periodic treatment of breast hyperplasia with traditional Chinese Medicine. Asia-Pacific Traditional Medicine. 2013;9(6):97-8.
  96. Liu JS, Zhao HJ. Clinical study on the treatment of breast hyperplasia with the combination of Chinese and Western Medicine. Medical Information. 2011;24(10):2971-2.
  97. Yu YYM. The Clinical Effect of Chinese and Western Medicine in the Treatment of Breast Hyperplasia. For All Health. 2013;7(5):83-4.
  98. Liu W, Fang SX, Lan Y. 800 cases of cystic hyperplasia of breast treated with Chinese and Western Medicine. Shaanxi J. of Traditional Chinese Medicine. 2008;29(7):792-3. https://doi.org/10.3969/j.issn.1000-7369.2008.07.021
  99. Rao YL. Rukang Decoction in the treatment of 86 cases of breast hyperplasia. Shenzhen J. of Integrated Traditional Chinese and Western Medicine. 2008;18(1):53-4. https://doi.org/10.3969/j.issn.1007-0893.2008.01.021
  100. Li YZ, et al. Tianqing Ruxiao Fang Wujian granule and methyltestosterone tablet in the treatment of breast cystic hyperplasia. For all Health. 2016;10(17):193-4.
  101. Guo J, et al. Therapeutic effect of traditional Chinese and Western Medicine on hyperplasia of mammary gland. Practical Clinical J. of Integrated Traditional Chinese and Western Medicine. 2012;12(6):13-5. https://doi.org/10.3969/j.issn.1671-4040.2012.06.007
  102. Li YY, Wang YW. The effect of Ruhexiao in the treatment of 76 cases of breast hyperplasia. Contemporary Medicine. 2012;18(3):14-5. https://doi.org/10.3969/j.issn.1009-4393.2012.3.009
  103. Rao YL. Rukang Decoction in the treatment of 86 cases of breast hyperplasia. Shenzhen J. of Integrated Traditional Chinese and Western Medicine. 2008;18(1):53-4. https://doi.org/10.3969/j.issn.1007-0893.2008.01.021
  104. Chen CB, Lu XQ, Xu JX. Clinical observation on the treatment of mammary hyperplasia with the combination of traditional Chinese and Western Medicine. J. of Henan University(MedicalScience). 2008;27(4):66-7. https://doi.org/10.3969/j.issn.1672-7606.2008.04.021
  105. Zhang H. Clinical observation on the treatment of 300 cases liver depression and phlegm coagulation type of mastoidosis with the combination of traditional Chinese and Western medicine. Medical Information(the first half of Xi'an). 2007;20(1):143-4.
  106. Zhang L, Huang BQ, Ai RD. Clinical Effect of Tiao Chong San Jie Tang on Cyclomastopathy of Chong and Ren Channel Disharmon. J. of Sichuan of Traditional Chinese Medicine. 2011;29(8):81-3.
  107. Yan HW, et al. Integrated Traditional Chinese Medicine and Western Medicine Treat Disease of CysticHyperplasia of Breast. J. of Zhejiang Chinese Medical University. 2008;32(4):483-4.
  108. Zhang HQ. Rupi Sanjie capsule and malt in the treatment of 60 cases of postpartum milk regression. Chinese J. of Drug Abuse Prevention and Treatment. 2011;17(4):221-2. https://doi.org/10.3969/j.issn.1006-902X.2011.04.012
  109. Wen YJ, Li GF. Observation on 60 cases of mammary hyperplasia treated with traditional Chinese Medicine. J. of Practical Traditional Chinese Medicine. 2015;31(5):379-80.
  110. Zhang HL. 132 cases of mammary hyperplasia treated with traditional Chinese medicine. Jiangsu traditional Chinese Medicine. 2009;41(7):49.
  111. Sun C, Li D. Clinical analysis of 100 cases of mammary hyperplasia treated by the combination of Chinese and Western Medicine. Electronic Journal of Clinical Medical Literature. 2016;3(47):9454.
  112. Zhao XH, Zhou WX, Xu RY. 100 cases of hyperplasia of mammary gland treated by xiaosanrukuai capsule. Shaanxi Traditional Chinese Medicine. 2007;28(11):1486-7.
  113. Chen MQ. 122 cases of breast hyperplasia treated by Gualou Xiebai Banxia Decoction and methyltestosterone. Zhejiang J. of Traditional Chinese Medicine. 2011;46(3):175. https://doi.org/10.3969/j.issn.0411-8421.2011.03.013
  114. Feng JM, et al. Clinical effect of Danqin Xiaoyu mixture on hyperplasia of mammary gland. Maternal and Child Health Care in China. 2016;31(24):5292-4.
  115. Lin X, Guo WPG, Yu M. 69 cases of Mammary Gland Hyperplasia treated by Rupi Sanjie Capsule, Chinese medicine guide. 2007;28(12):1631-2.
  116. Zhang JQ, Zhang YM, Zhao SJ. Clinical observation of tamoxifen citrate tablets combined with Rupixiao tablets in the treatment of 81 cases of breast hyperplasia. Hebei Traditional Chinese Medicine. 2013;35(10):1514-5.
  117. Liu XiP. Analysis of 30 cases of breast hyperplasia treated with Xiaoyao Loubei powder. Chinese Remedies & Clinics. 2012;12(7):956-7. https://doi.org/10.3969/j.issn.1671-2560.2012.07.058
  118. Zhang LY, Zhao GQi, Zhang H. Clinical observation of Xiaozeng Decoction in the treatment of breast hyperplasia. Chinese J. of modern medicine 2011;13(9):96-7.
  119. Zhao HJ, Fan W, Qi YE. Clinical observation on 50 cases of mammary hyperplasia treated with tamoxifen and Kun runing granules. Hebei Traditional Chinese medicine. 2010;32(4):549-50.
  120. Zhou LJM, Ma Y. The treatment of lobular hyperplasia of the breast. China Medical Journal. 2019;16(20):53-6.