Journal of the Korean Dietetic Association (대한영양사협회학술지)

The Korean Dietetic Association (대한영양사협회)
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Changes in Blood Parameters and Blood Flow Subsequent to a Short-Term Raw Juice Diet

단기간 생즙섭취에 따른 혈액지표 및 혈류변화

  • Kim, Sun-Hee (Dept. of Public Health, Sahmyook University Graduate School) ;
  • Yim, Jong-Eun (Dept. of Physical Therapy, Sahmyook University) ;
  • Yun, Mi-Eun (Dept. of Food and Nutrition, Sahmyook University)
  • 김선희 (삼육대학교 일반대학원 보건학과) ;
  • 임종은 (삼육대학교 물리치료학과) ;
  • 윤미은 (삼육대학교 식품영양학과)
  • Received : 2019.10.30
  • Accepted : 2020.01.13
  • Published : 2020.02.02
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Abstract

Dietary nitrate supplementation from green leafy vegetables and beetroot is involved in the 'nitrate-nitrite-nitric oxide (NO) pathway' and is reported to have important vascular impacts. This study evaluated the blood parameters and blood flow change subsequent to a raw juice diet program. The 28 subjects who voluntarily participated in the raw juice diet program at Sahmyook University were instructed to drink the juice composed of fruits and vegetables instead of partaking the usual meal, at a scheduled time daily. The study was approved by the research ethics council of the Sahmyook University (SYUIRB 2014-043). Evaluation of the participants after the required duration revealed decreased levels of soft lean mass (P<0.05), skeletal muscle mass (P<0.001), body fat mass (P<0.001), body mass index (P<0.001) and circulating levels of total cholesterol (P<0.001), triglycerides (P<0.05), HDL-cholesterol (P<0.01), LDL-cholesterol (P<0.01), and blood urea nitrogen (P<0.001). Conversely, circulating levels of creatinine (P<0.001), hemoglobin (P<0.001), and hematocrit (P<0.01) were increased after the intervention. The blood flow levels were also increased after the program (P<0.001). Our results indicate that a short-term raw juice diet contributes to the improvement of vascular blood flow and blood lipid parameters, and decreases the lean muscle mass related to dehydration.

Keywords

References

  1. Alshiek JA, Dayan L, Asleh R, Blum S, Levy AP, Jacob G (2017): Anti-oxidative treatment with vitamin E improves peripheral vascular function in patients with diabetes mellitus and Haptoglobin 2-2 genotype: a double-blinded cross-over study. Diabetes Res Clin Pract 131:200-207 https://doi.org/10.1016/j.diabres.2017.06.026
  2. Bielli A, Scioli MG, Mazzaglia D, Doldo E, Orlandi A (2015): Antioxidants and vascular health. Life Sci 143:209-216 https://doi.org/10.1016/j.lfs.2015.11.012
  3. Brkic D, Bosnir J, Bevardi M, Boskovic AG, Milos S, Lasic D, Krivohlavek A, Racz A, Cuic AM, Trstenjak NU (2017): Nitrate in leafy green vegetables and estimated intake. Afr J Tradit Complement Altern Med 14(3):31-41 https://doi.org/10.21010/ajtcam.v14i3.4
  4. Burgos CM, Davey MG, Riley JS, Jia H, Flake AW, Peranteau WH (2018): Lung function and pulmonary artery blood flow following prenatal maternal retinoic acid and imatinib in the nitrofen model of congenital diaphragmatic hernia. J Pediatr Surg 53(9):1681-1687 https://doi.org/10.1016/j.jpedsurg.2017.12.002
  5. Cai H, Harrison DG (2000): Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 87(10):840-844 https://doi.org/10.1161/01.RES.87.10.840
  6. Chen Q, Wang Q, Zhu J, Xiao Q, Zhang L (2018): Reactive oxygen species: key regulators in vascular health and diseases. Br J Pharmacol 175(8):1279-1292 https://doi.org/10.1111/bph.13828
  7. Choi HS (2014): Effect of dietary nitrate supplementation on early stage of physiological acclimatization during exercise in hypoxia. Masters degree thesis. Korea National Sport University. pp.5-15
  8. Constans J, Bennetau-Pelissero C, Martin JF, Rock E, Mazur A, Bedel A, Morand C, Berard AM (2015): Marked antioxidant effect of orange juice intake and its phytomicronutrients in a preliminary randomized cross-over trial on mild hypercholesterolemic men. Clin Nutr 34(6):1093-1100 https://doi.org/10.1016/j.clnu.2014.12.016
  9. Cosby K, Partovi KS, Crawford JH, Patel RP, Reiter CD, Martyr S, Yang BK, Waclawiw MA, Zalos G, Xu X, Huang KT, Shields H, Kim-Shapiro DB, Schechter AN, Cannon RO 3rd, Gladwin MT (2003): Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation. Nat Med 9:1498-1505 https://doi.org/10.1038/nm954
  10. Dauchet L, Ferrieres J, Arveiler D, Yarnell JW, Gey F, Ducimetiere P, Ruidavets JB, Haas B, Evans A, Bingham A, Amouyel P, Dallongeville J (2004): Frequency of fruit and vegetable consumption and coronary heart disease in France and Northern Ireland: the PRIME study. Br J Nutr 92(6):963-972 https://doi.org/10.1079/BJN20041286
  11. Ferguson SK, Hirai DM, Copp SW, Holdsworth CT, Allen JD, Jones AM, Musch TI, Poole DC (2013): Impact of dietary nitrate supplementation via beetroot juice on exercising muscle vascular control in rats. J Physiol 591(2):547-557 https://doi.org/10.1113/jphysiol.2012.243121
  12. Guarnieri S, Riso P, Porrini M (2007): Orange juice vs vitamin C: effect on hydrogen peroxide-induced DNA damage in mononuclear blood cells. Br J Nutr 97(4):639-643 https://doi.org/10.1017/S0007114507657948
  13. Guasch-Ferre M, Satija A, Blondin SA, Janiszewski M, Emlen E, O'Connor LE, Campbell WW, Hu FB, Willett WC, Stampfer MJ (2019): Meta-analysis of randomized controlled trials of red meat consumption in comparison with various comparison diets on cardiovascular risk factors. Circulation 139(15):1828-1845 https://doi.org/10.1161/CIRCULATIONAHA.118.035225
  14. Hansen L, Skeie G, Landberg R, Lund E, Palmqvist R, Johansson I, Dragsted LO, Egeberg R, Johnsen NF, Christensen J, Overvad K, Tjonneland A, Olsen A (2012): Intake of dietary fiber, especially from cereal foods, is associated with lower incidence of colon cancer in the HELGA cohort. Int J Cancer 131(2):469-478 https://doi.org/10.1002/ijc.26381
  15. Hosten AO (1990). Clinical methods: the history, physical, and laboratory examinations, 3rd edition. Available from: https://www.ncbi.nlm.nih.gov/books/NBK305/. Accessed August 28, 2019
  16. Huynh DTN, Heo KS (2019): Therapeutic targets for endothelial dysfunction in vascular diseases. Arch Pharm Res 42(10):848-861 https://doi.org/10.1007/s12272-019-01180-7
  17. Johnston CS, Dancho CL, Strong GM (2003): Orange juice ingestion and supplemental vitamin C are equally effective at reducing plasma lipid peroxidation in healthy adult women. J Am Coll Nutr 22(6):519-523 https://doi.org/10.1080/07315724.2003.10719330
  18. Joris PJ, Mensink RP (2013): Beetroot juice improves in overweight and slightly obese men postprandial endothelial function after consumption of a mixed meal. Atherosclerosis 231(1):78-83 https://doi.org/10.1016/j.atherosclerosis.2013.09.001
  19. Joshipura KJ, Hu FB, Manson JE, Stampfer MJ, Rimm EB, Speizer FE, Colditz G, Ascherio A, Rosner B, Spiegelman D, Willett WC (2001): The effect of fruit and vegetable intake on risk for coronary heart disease. Ann Intern Med 134(12):1106-1114 https://doi.org/10.7326/0003-4819-134-12-200106190-00010
  20. Kim SY, Yoon S, Kwon SM, Park KS, Lee-Kim YC (2008): Kale juice improves coronary artery disease risk factors in hypercholesterolemic men. Biomed Environ Sci 21(2):91-97 https://doi.org/10.1016/S0895-3988(08)60012-4
  21. Kurowska EM, Borradaile NM, Spence JD, Carroll KK (2000): Hypocholesterolemic effects of dietary citrus juices in rabbits. Nutr Res 20(1):121-129 https://doi.org/10.1016/S0271-5317(99)00144-X
  22. Landberg R, Naidoo N, van Dam RM (2012): Diet and endothelial function: from individual components to dietary patterns. Curr Opin Lipidol 23(2):147-155 https://doi.org/10.1097/MOL.0b013e328351123a
  23. Lee HJ, Moon TH, No BS, Jang PS, Back HH, Lee KG, Kim SJ, You SH, Lee KW (2015): Food chemistry. Suhaksa. Seoul. pp.458-459
  24. Lidder S, Webb AJ (2013): Vascular effects of dietary nitrate (as found in green leafy vegetables and beetroot) via the nitrate-nitrite-nitric oxide pathway. Br J Clin Pharmacol 75(3):677-696 https://doi.org/10.1111/j.1365-2125.2012.04420.x
  25. Maloney-Hinds C, Petrofsky JS, Zimmerman G, Hessinger DA (2009): The role of nitric oxide in skin blood flow increases due to vibration in healthy adults and adults with type 2 diabetes. Diabetes Technol Ther 11(1):39-43 https://doi.org/10.1089/dia.2008.0011
  26. May JM, Harrison FE (2013): Role of vitamin C in the function of the vascular endothelium. Antioxid Redox Signal 19(17):2068-2083 https://doi.org/10.1089/ars.2013.5205
  27. Mayer B (2000). Nitric oxide. Available from: https://books.google.co.kr/books?id=TwsewPRyMvAC&pg=PA493&dq=nitric+oxide&hl=ko&sa=X&ved=0ahUKEwiop8SexrHkAhUizIsBHQUOATMQ6AEIUTAF#v=onepage&q=nitric%20oxide&f=false. Accessed August 28, 2019
  28. Miyake Y, Mochizuki M, Okada M, Hiramitsu M, Morimitsu Y, Osawa T (2007): Isolation of antioxidative phenolic glucosides from lemon juice and their suppressive effect on the expression of blood adhesion molecules. Biosci Biotechnol Biochem 71(8):1911-1919 https://doi.org/10.1271/bbb.70115
  29. National Kidney Foundation (2013): Can dehydration cause creatinine to rise? If so, by what factor? Available from: https://www.kidney.org/blog/ask-doctor/can-dehydration-cause-creatinine-rise-if-so-what-factor. Accessed July 30, 2019
  30. National Research Council (U.S.). Committee on Animal Nutrition (2003). Available from: https://books.google.co.kr/books?id=FcA6zIq0d48C&printsec=frontcover&dq=Nutrient+Requirements+of+Nonhuman+Primates&hl=ko&sa=X&ved=0ahUKEwjD2aTX9p3kAhXKGaYKHfJ5BK0Q6AEIKjAA#v=onepage&q=Nutrient%20Requirements%20of%20Nonhuman%20Primates&f=false. Accessed July 30, 2019
  31. Petrofsky J, Berk L, Al-Nakhli H (2012): The influence of autonomic dysfunction associated with aging and type 2 diabetes on daily life activities. Exp Diabetes Res 2012:657103
  32. Reshef N, Hayari Y, Goren C, Boaz M, Madar Z, Knobler H (2005): Antihypertensive effect of sweetie fruit in patients with stage I hypertension. Am J Hypertens 18(10):1360-1363 https://doi.org/10.1016/j.amjhyper.2005.05.021
  33. Rokitzki L, Logemann E, Sagredos AN, Murphy M, Wetzel-Roth W, Keul J (1994): Lipid peroxidation and antioxidative vitamins under extreme endurance stress. Acta Physiol Scand 151(2):149-158 https://doi.org/10.1111/j.1748-1716.1994.tb09732.x
  34. Sacheck JM, Blumberg JB (2001): Role of vitamin E and oxidative stress in exercise. Nutrition 17(10):809-814 https://doi.org/10.1016/S0899-9007(01)00639-6
  35. Samra M, Abcar AC (2012): False estimates of elevated creatinine. Perm J 16(2):51-52
  36. Santamaria P (2006): Nitrate in vegetables: toxicity, content, intake and EC regulation. J Sci Food Agric 86(1):10-17 https://doi.org/10.1002/jsfa.2351
  37. Schwingshackl L, Hoffmann G (2014): Comparison of high vs. normal/low protein diets on renal function in subjects without chronic kidney disease: a systematic review and meta-analysis. PLoS One 9(5):e97656 https://doi.org/10.1371/journal.pone.0097656
  38. The Korean Society for Laboratary Medicine LAB Tests Onlline (2017). BUN. Available from: https://labtestsonline.kr/tests/bun. Accessed July 30, 2019
  39. Vara D, Pula G (2014): Reactive oxygen species: physiological roles in the regulation of vascular cells. Curr Mol Med 14(9):1103-1125 https://doi.org/10.2174/1566524014666140603114010
  40. Xie D, Zhong H, Mo J, Li Z, Cui T, Yi C (2007): Nutritional and medicinal quality of pear juice: next hotspot? Food 1(1):41-48
  41. Zhao L, Wang L, Zhang Y (2009): Elevated admission serum creatinine predicts poor myocardial blood flow and one-year mortality in ST-segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention. J Invasive Cardiol 21(10):493-498