Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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IL-10 Expression-Inducing Gut Bacteria Alleviate High-Fat Diet-Induced Obesity and Hyperlipidemia in Mice

  • Kim, Hye-In (Department of Food and Nutrition, Kyung Hee University) ;
  • Yun, Soo-Won (Department of Food and Nutrition, Kyung Hee University) ;
  • Han, Myung Joo (Department of Food and Nutrition, Kyung Hee University) ;
  • Jang, Se-Eun (Department of Life and Nanopharmaceutical Sciences and Department of Pharmacy, Kyung Hee University) ;
  • Kim, Dong-Hyun (Department of Life and Nanopharmaceutical Sciences and Department of Pharmacy, Kyung Hee University)
  • Received : 2019.12.10
  • Accepted : 2020.01.03
  • Published : 2020.04.28
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Abstract

In the present study, we examined the effects of interleukin (IL)-10 expression-inducing bacteria Bifidobacterium adolescentis HP1, Lactobacillus mucosae HP2, and Weissella cibaria HP3 on high-fat diet (HFD)-induced obesity and liver steatosis in mice. Oral gavage of HP1, HP2, and HP3 reduced HFD-induced bodyweight gain, triglycerides, and total cholesterol levels in the blood and liver. They also suppressed HFD-induced colitis and the fecal δ,γ-Proteobacteria population. Of the tested bacteria, HP2, which most potently inhibited IL-10 expression, also suppressed HFD-induced bodyweight gain, liver steatosis, and colitis most effectively. These findings suggest that IL-10 expression-inducing gut bacteria can suppress obesity and liver steatosis.

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