The korean journal of orthodontics (대한치과교정학회지)

The Korean Association Of Orthodontists (대한치과교정학회)
권호 표지
DOI QR코드

DOI QR Code

The effect of cetirizine, a histamine 1 receptor antagonist, on bone remodeling after calvarial suture expansion

  • Hwang, Soonshin (Department of Orthodontics, Gangnam Severance Dental Hospital, College of Dentistry, Yonsei University) ;
  • Chung, Chooryung J. (Department of Orthodontics, Gangnam Severance Dental Hospital, College of Dentistry, Yonsei University) ;
  • Choi, Yoon Jeong (Department of Orthodontics and Institute of Craniofacial Deformity, College of Dentistry, Yonsei University) ;
  • Kim, Taeyeon (Department of Orthodontics, Gangnam Severance Dental Hospital, College of Dentistry, Yonsei University) ;
  • Kim, Kyung-Ho (Department of Orthodontics, Gangnam Severance Dental Hospital, College of Dentistry, Yonsei University)
  • Received : 2019.06.04
  • Accepted : 2019.08.21
  • Published : 2020.01.25
Download PDF
⟨ Previous Next ⟩

Abstract

Objective: The objective of this study was to evaluate the effects of cetirizine, a histamine 1 receptor antagonist, on bone remodeling after calvarial suture expansion. Methods: Sixty male Sprague-Dawley rats were divided into 4 groups; the phosphate-buffered saline (PBS)-injected no expansion group, cetirizine-injected no expansion group, PBS-injected expansion group, and cetirizine-injected expansion group, and were observed at 7, 14, and 28 days. Five rats per group were examined at each observation day. Daily injections of cetirizine or PBS were administered to the relevant groups starting 2 weeks prior to expander insertion. A rapid expander was inserted in the calvarial bone to deliver 100 cN of force to the parietal suture. The specimens were prepared for hematoxylin and eosin and tartrate-resistant acid phosphatase (TRAP) staining. Suture opening and bone regeneration were evaluated using microcomputed tomography and bone histomorphometric analysis. Serum blood levels of osteocalcin and carboxy-terminal collagen crosslinks (CTX) were also evaluated. Results: TRAP-positive cell counts and CTX levels decreased while osteocalcin levels increased in the cetirizine-injected expansion group at observation day 28. In the expansion groups, the mineralized area gradually increased throughout the observation period. At day 28, the cetirizine-injected expansion group showed greater bone volume density, greater mineralized area, and narrower average suture width than did the PBS-injected expansion group. Conclusions: Cetirizine injection facilitated bone formation after suture expansion, mostly by suppressing osteoclastic activity. Histamine 1 receptor antagonists may aid in bone formation after calvarial suture expansion in the rat model.

Keywords

References

  1. Takizawa H. Impact of air pollution on allergic diseases. Korean J Intern Med 2011;26:262-73. https://doi.org/10.3904/kjim.2011.26.3.262
  2. Hajar T, Simpson EL. The rise in atopic dermatitis in young children: what is the explanation? JAMA Netw Open 2018;1:e184205. https://doi.org/10.1001/jamanetworkopen.2018.4205
  3. Song S, Lee K, Lee YM, Lee JH, Lee SI, Yu SD, et al. Acute health effects of urban fine and ultrafine particles on children with atopic dermatitis. Environ Res 2011;111:394-9. https://doi.org/10.1016/j.envres.2010.10.010
  4. Xu F, Yan S, Li F, Cai M, Chai W, Wu M, et al. Prevalence of childhood atopic dermatitis: an urban and rural community-based study in Shanghai, China. PLoS One 2012;7:e36174. https://doi.org/10.1371/journal.pone.0036174
  5. Kim YM, Kim J, Han Y, Jeon BH, Cheong HK, Ahn K. Short-term effects of weather and air pollution on atopic dermatitis symptoms in children: a panel study in Korea. PLoS One 2017;12:e0175229. https://doi.org/10.1371/journal.pone.0175229
  6. Bachert C. Histamine--a major role in allergy? Clin Exp Allergy 1998;28 Suppl 6:15-9. https://doi.org/10.1046/j.1365-2222.1998.0280s6015.x
  7. Buddenkotte J, Maurer M, Steinhoff M. Histamine and antihistamines in atopic dermatitis. In: Thurmond RL, ed. Histamine in inflammation. New York: Springer; 2010. p. 73-80.
  8. Seeman E. Structural basis of growth-related gain and age-related loss of bone strength proceedings of a satellite symposium held on the occasion of the EULAR Congress, Paris, France, June 13, 2008. Rheumatology 2008;47:iv2-8. https://doi.org/10.1093/rheumatology/ken177
  9. Johansson C, Roupe G, Lindstedt G, Mellstrom D. Bone density, bone markers and bone radiological features in mastocytosis. Age Ageing 1996;25:1-7. https://doi.org/10.1093/ageing/25.1.1
  10. Folwarczna J, Sliwinski L, Pytlik M, Janas A. Effects of histamine H1, H2 and H3 receptor antagonists on bone mechanical properties in female rats. Bone 2011;48:S193.
  11. Dobigny C, Saffar JL. H1 and H2 histamine receptors modulate osteoclastic resorption by different pathways: evidence obtained by using receptor antagonists in a rat synchronized resorption model. J Cell Physiol 1997;173:10-8. https://doi.org/10.1002/(SICI)1097-4652(199710)173:1<10::AID-JCP2>3.0.CO;2-M
  12. Mandhane SN, Shah JH, Thennati R. Allergic rhinitis: an update on disease, present treatments and future prospects. Int Immunopharmacol 2011;11:1646-62. https://doi.org/10.1016/j.intimp.2011.07.005
  13. Kawauchi H, Yanai K, Wang DY, Itahashi K, Okubo K. Antihistamines for allergic rhinitis treatment from the viewpoint of nonsedative properties. Int J Mol Sci 2019;20:E213.
  14. Luzzi V, Ierardo G, Viscogliosi A, Fabbrizi M, Consoli G, Vozza I, et al. Allergic rhinitis as a possible risk factor for malocclusion: a case-control study in children. Int J Paediatr Dent 2013;23:274-8. https://doi.org/10.1111/ipd.12003
  15. Pawankar R, Canonica GW, Holgate ST, Lockey RF, Blaiss M. World Allergy Organization (WAO) white book on allergy. Milwaukee, WI: World Allergy Organization; 2011.
  16. Meh A, Sprogar S, Vaupotic T, Cor A, Drevensek G, Marc J, et al. Effect of cetirizine, a histamine (H(1)) receptor antagonist, on bone modeling during orthodontic tooth movement in rats. Am J Orthod Dentofacial Orthop 2011;139:e323-9. https://doi.org/10.1016/j.ajodo.2009.11.013
  17. Parfitt AM, Drezner MK, Glorieux FH, Kanis JA, Malluche H, Meunier PJ, et al. Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 1987;2:595-610. https://doi.org/10.1002/jbmr.5650020617
  18. Mao JJ, Wang X, Kopher RA. Biomechanics of craniofacial sutures: orthopedic implications. Angle Orthod 2003;73:128-35.
  19. Kobayashi ET, Hashimoto F, Kobayashi Y, Sakai E, Miyazaki Y, Kamiya T, et al. Force-induced rapid changes in cell fate at midpalatal suture cartilage of growing rats. J Dent Res 1999;78:1495-504. https://doi.org/10.1177/00220345990780090301
  20. Opperman LA. Cranial sutures as intramembranous bone growth sites. Dev Dyn 2000;219:472-85. https://doi.org/10.1002/1097-0177(2000)9999:9999<::AID-DVDY1073>3.0.CO;2-F
  21. Wu BH, Kou XX, Zhang C, Zhang YM, Cui Z, Wang XD, et al. Stretch force guides finger-like pattern of bone formation in suture. PLoS One 2017;12:e0177159. https://doi.org/10.1371/journal.pone.0177159
  22. Hou B, Fukai N, Olsen BR. Mechanical force-induced midpalatal suture remodeling in mice. Bone 2007;40:1483-93. https://doi.org/10.1016/j.bone.2007.01.019
  23. Lai RF, Zhou ZY, Chen T. Accelerating bone generation and bone mineralization in the interparietal sutures of rats using an rhBMP-2/ACS composite after rapid expansion. Exp Anim 2013;62:189-96. https://doi.org/10.1538/expanim.62.189
  24. Matuszewska A, Nowak B, Jedrzejuk D, Landwojtowicz M, Sadanowicz E, Sozanski T, et al. Effect of long-term administration of ranitidine, a histamine H2 receptor antagonist, on bone metabolism in young growing rats. Pharmacol Rep 2018;70:951-4. https://doi.org/10.1016/j.pharep.2018.03.005
  25. Biosse-Duplan M, Baroukh B, Dy M, de Vernejoul MC, Saffar JL. Histamine promotes osteoclastogenesis through the differential expression of histamine receptors on osteoclasts and osteoblasts. Am J Pathol 2009;174:1426-34. https://doi.org/10.2353/ajpath.2009.080871
  26. Lesclous P, Guez D, Saffar JL. Short-term prevention of osteoclastic resorption and osteopenia in ovariectomized rats treated with the H(2) receptor antagonist cimetidine. Bone 2002;30:131-6. https://doi.org/10.1016/S8756-3282(01)00629-9
  27. Yamaura K, Yonekawa T, Nakamura T, Yano S, Ueno K. The histamine H2-receptor antagonist, cimetidine, inhibits the articular osteopenia in rats with adjuvant-induced arthritis by suppressing the osteoclast differentiation induced by histamine. J Pharmacol Sci 2003;92:43-9. https://doi.org/10.1254/jphs.92.43
  28. Civitelli R, Armamento-Villareal R, Napoli N. Bone turnover markers: understanding their value in clinical trials and clinical practice. Osteoporos Int 2009;20:843-51. https://doi.org/10.1007/s00198-009-0838-9
  29. Garnero P, Ferreras M, Karsdal MA, Nicamhlaoibh R, Risteli J, Borel O, et al. The type I collagen fragments ICTP and CTX reveal distinct enzymatic pathways of bone collagen degradation. J Bone Miner Res 2003;18:859-67. https://doi.org/10.1359/jbmr.2003.18.5.859