Journal of Veterinary Science

  • 제21권1호
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  • Pages.6.1-6.12
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  • 2020
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  • 1229-845X(pISSN)
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  • 1976-555X(eISSN)
대한수의학회 (The Korean Society of Veterinary Science)
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Comparison of the trometamol-balanced solution with two other crystalloid solutions for fluid resuscitation of a rat hemorrhagic model

  • Ting, Wen-Ting (Department and Graduate Institute of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University) ;
  • Chang, Ru-Wen (Cardiovascular Surgery, Department of Surgery, National Taiwan University Hospital, National Taiwan University) ;
  • Wang, Chih-Hsien (Cardiovascular Surgery, Department of Surgery, National Taiwan University Hospital, National Taiwan University) ;
  • Chen, Yih-Sharng (Cardiovascular Surgery, Department of Surgery, National Taiwan University Hospital, National Taiwan University) ;
  • Lee, Jih-Jong (Department and Graduate Institute of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University)
  • 투고 : 2019.05.18
  • 심사 : 2019.10.21
  • 발행 : 2020.01.31
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초록

Currently, the optimal resuscitation fluid remains debatable. Therefore, in the present study, we designed a trometamol-balanced solution (TBS) for use as a resuscitation fluid for hemorrhagic shock. Hemorrhagic shock was induced in 18 male Wistar-Kyoto rats, which were assigned to normal saline (NS), Ringer's solution (RS), and TBS groups. During the hemorrhagic state, their hemodynamic parameters were recorded using an Abbott i-STAT analyzer with the CG4+ cartridge (for pH, pressure of carbon dioxide, pressure of oxygen, total carbon dioxide, bicarbonate, base excess, oxygen saturation, and lactate), the CG6+ cartridge (for sodium, potassium, chloride, blood glucose, blood urea nitrogen, hematocrit, and hemoglobin), and enzyme-linked immunosorbent assay kits (calcium, magnesium, creatinine, aspartate aminotransferase, alanine aminotransferase, bilirubin, and albumin). Similar trends were found for the parameters of biochemistries, electrolytes, and blood gas, and they revealed no significant changes after blood withdrawal-induced hemorrhagic shock. However, the TBS group showed more effective ability to correct metabolic acidosis than the NS and RS groups. TBS was a feasible and safe resuscitation solution in this study and may be an alternative to NS and RS for resuscitation in hemorrhagic shock patients without liver damage.

키워드

과제정보

This study was supported by grants from the National Science Council of Taiwan (MOST 102-2314-B-002-169-MY2) and National Taiwan University Hospital (106-16).

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