Acknowledgement
This study was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. 2018R1C1B6006044).
References
- 보건복지부, 중앙암등록본부, 국립암센터. 국가암등록사업 연례 보고서(2016년 암등록통계). 2019.
- Khorana AA, Fine RL. Pancreatic cancer and thromboembolic disease. The Lancet Oncology 2004;5(11):655-663. https://doi.org/10.1016/S1470-2045(04)01606-7
- Menapace LA, Peterson DR, Berry A, et al. Symptomatic and incidental thromboembolism are both associated with mortality in pancreatic cancer. Thromb Haemost 2011;106(08):371-378. https://doi.org/10.1160/TH10-12-0789
- Falanga A, Russo L. Epidemiology, risk and outcomes of venous thromboembolism in cancer. Hamostaseologie 2012;32(02):115-125. https://doi.org/10.5482/ha-1170
- Heit JA, Silverstein MD, Mohr DN, et al. Risk factors for deep vein thrombosis and pulmonary embolism: a population-based case-control study. Arch Intern Med 2000;160(6):809-815. https://doi.org/10.1001/archinte.160.6.809
- Ansari D, Ansari D, Andersson R, et al. Pancreatic cancer and thromboembolic disease, 150 years after Trousseau. Hepatobiliary Surg Nutr 2015;4(5):325.
- Blom J, Osanto S, Rosendaal F. High risk of venous thrombosis in patients with pancreatic cancer: a cohort study of 202 patients. Eur J Cancer 2006;42(3):410-414. https://doi.org/10.1016/j.ejca.2005.09.013
- Iodice S, Gandini S, Lohr M, et al. Venous thromboembolic events and organ-specific occult cancers: A review and meta-analysis. J Thromb Haemost 2008;6(5):781-788. https://doi.org/10.1111/j.1538-7836.2008.02928.x
- Horsted F, West J, Grainge MJ. Risk of venous thromboembolism in patients with cancer: A systematic review and metaanalysis. PLoS Med 2012;9(7).
- Oh SY, Kim JH, Lee K-W, et al. Venous thromboembolism in patients with pancreatic adenocarcinoma: lower incidence in Asian ethnicity. Thromb Res 2008;122(4):485-490. https://doi.org/10.1016/j.thromres.2007.12.015
- Khorana A, Culakova E, Lyman G, et al. Incidence of thromboembolic events in a prospective nationwide registry of cancer patients initiating systemic chemotherapy. J Clin Oncol 2004;22(14 Suppl):8019. https://doi.org/10.1200/jco.2004.22.90140.8019
- Jang M, BANG SM, Oh D. Incidence of venous thromboembolism in Korea: from the health insurance review and assessment Service database. J Thromb Haemost 2011;9(1):85-91. https://doi.org/10.1111/j.1538-7836.2010.04108.x
- Choi F. Venous thromboembolism in the Chinese population - experience in a regional hospital in Hong Kong. Hong Kong Med J 2002;8(6):400-405.
- Cheuk B, Cheung G, Cheng S. Epidemiology of venous thromboembolism in a Chinese population. Br J Surg 2004;91(4):424-428. https://doi.org/10.1002/bjs.4454
- Molina JAD, Gabriel ZJ, Heng BH, et al. Venous thromboembolism at the National Healthcare group, Singapore. Ann Acad Med Singapore 2009;38(6):470.
- Lee J-C, Ro YS, Cho J, et al. Characteristics of venous thromboembolism in pancreatic adenocarcinoma in east Asian ethnics: a large population-based observational study. Medicine 2016;95(17).
- Frere C, Bournet B, Gourgou S, et al. Incidence of venous thromboembolism in patients with newly diagnosed pancreatic cancer and factors associated with outcomes. Gastroenterology 2019.
- Sgouros J, Maraveyas A. Excess premature (3-month) mortality in advanced pancreatic cancer could be related to fatal vascular thromboembolic events. A hypothesis based on a systematic review of phase III chemotherapy studies in advanced pancreatic cancer. Acta Oncologica 2008;47(3):337-346. https://doi.org/10.1080/02841860701687267
- Engelberg H. Actions of heparin that may affect the malignant process. Cancer 1999;85(2):257-272. https://doi.org/10.1002/(SICI)1097-0142(19990115)85:2<257::AID-CNCR1>3.0.CO;2-2
- Varki NM, Varki A, editors. Heparin inhibition of selectinmediated interactions during the hematogenous phase of carcinoma metastasis: rationale for clinical studies in humans. Semin Thromb Hemost 2002.
- Icli F, Akbulut H, Utkan G, et al. Low molecular weight heparin(LMWH) increases the efficacy of cisplatinum plus gemcitabine combination in advanced pancreatic cancer. J Surg Oncol 2007;95(6):507-512. https://doi.org/10.1002/jso.20728
- van Doormaal FF, Di Nisio M, Otten H-M, et al. Randomized trial of the effect of the low molecular weight heparin nadroparin on survival in patients with cancer. J Clin Oncol 2011;29(15):2071-2076. https://doi.org/10.1200/JCO.2010.31.9293
- Pelzer U, Opitz B, Deutschinoff G, et al. Efficacy of prophylactic low-molecular weight heparin for ambulatory patients with advanced pancreatic cancer: outcomes from the CONKO-004 trial. J Clin Oncol 2015;33(18):2028-2034. https://doi.org/10.1200/JCO.2014.55.1481
- Meyer G, Marjanovic Z, Valcke J, et al. Comparison of low-molecular-weight heparin and warfarin for the secondary prevention of venous thromboembolism in patients with cancer: a randomized controlled study. Arch Intern Med. 2002;162(15):1729-1735. https://doi.org/10.1001/archinte.162.15.1729
- Lee AY, Levine MN, Baker RI, et al. Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer. N Engl J Med 2003;349(2):146-153. https://doi.org/10.1056/NEJMoa025313
- Lee AY, Kamphuisen PW, Meyer G, et al. Tinzaparin vs warfarin for treatment of acute venous thromboembolism in patients with active cancer: a randomized clinical trial. JAMA 2015;314(7):677-686. https://doi.org/10.1001/jama.2015.9243
- Martinez C, Katholing A, Wallenhorst C, et al. Therapy persistence in newly diagnosed non-valvular atrial fibrillation treated with warfarin or NOAC. Thromb Haemost 2016;115(01):31-39. https://doi.org/10.1160/TH15-04-0350
- Nielsen PB, Skjoth F, Sogaard M, et al. Effectiveness and safety of reduced dose non-vitamin K antagonist oral anticoagulants and warfarin in patients with atrial fibrillation: propensity weighted nationwide cohort study. BMJ 2017;356:j510.
- Khorana AA, Vadhan-Raj S, Kuderer NM, et al. Rivaroxaban for preventing venous thromboembolism in high-risk ambulatory patients with cancer: Rationale and design of the CASSINI trial. Thromb Haemost 2017;117(11):2135-2145. https://doi.org/10.1160/TH17-03-0171
- Khorana AA, Soff GA, Kakkar AK, et al. Rivaroxaban for thromboprophylaxis in high-risk ambulatory patients with cancer. N Engl J Med 2019;380(8):720-728. https://doi.org/10.1056/NEJMoa1814630