Pediatric Gastroenterology, Hepatology & Nutrition

The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition (대한소아소화기영양학회)
권호 표지
DOI QR코드

DOI QR Code

Gastric Xanthoma in the Pediatric Population: A Possible Herald for Malignancy?

  • Russell, Joseph D. (Department of Undergraduate Studies, University of South Florida) ;
  • Peck, Jacquelin (Department of Anesthesiology, Mount Sinai Medical Center) ;
  • Phen, Claudia (Department of Pediatric Gastroenterology, UT Southwestern Medical Center) ;
  • Linehan, Janna L. (Department of Undergraduate Studies, University of South Florida) ;
  • Karjoo, Sara (Department of Gastroenterology and Nutrition, Johns Hopkins All Children's Hospital) ;
  • Nguyen, Johnny (Department of Anatomic and Clinical Pathology, Johns Hopkins All Children's Hospital) ;
  • Wilsey, Michael J. (Department of Gastroenterology and Nutrition, Johns Hopkins All Children's Hospital)
  • Received : 2019.09.02
  • Accepted : 2019.11.30
  • Published : 2020.01.15
Download PDF
⟨ Previous Next ⟩

Abstract

Gastric xanthoma is frequently an incidental finding on upper endoscopy in adults. Gastric xanthomas (GX) can be mistaken for malignancies and warrant prompt histologic diagnosis. The underlying etiology is not fully understood; however, it has been linked to Helicobacter pylori gastritis and gastric cancer. GX in the pediatric population is largely unreported in the literature. Because of the relative rarity, documentation with case reports are essential to provide as much data as possible to see if there is a correlation between GX and malignant potential in the pediatric population. Our group is reporting two cases, a 10-year-old male and a 7-year-old male, both who presented with chronic dysphagia, upper abdominal pain, nausea, vomiting, and loss of appetite. Upper endoscopies for both patients revealed small polypoid lesions located in the antrum with foamy histiocytes on histology, leading to the diagnosis of gastric xanthoma.

Keywords

References

  1. Basyigit S, Kefeli A, Asilturk Z, Sapmaz F, Aktas B. Gastric xanthoma: a review of the literature. Shiraz E Med J 2015:16.
  2. Alzahrani M, Alqunaitir A, Alsohaibani M, Al-Rikabi AC. Gastric xanthelasma associated with hyperplastic polyp and mucosal erosions: report of an unusual case and literature review. Oxf Med Case Reports 2018;2018:omy051.
  3. Shibukawa N, Ouchi S, Wakamatsu S, Wakahara Y, Kaneko A. Gastric xanthoma is a predictive marker for metachronous and synchronous gastric cancer. World J Gastrointest Oncol 2017;9:327-32. https://doi.org/10.4251/wjgo.v9.i8.327
  4. Shibukawa N, Ouchi S, Wakamatsu S, Wakahara Y, Kaneko A. Gastric xanthoma is a predictive marker for early gastric cancer detected after helicobacter pylori eradication. Intern Med 2019;58:779-84. https://doi.org/10.2169/internalmedicine.0925-18
  5. Gasparetto M, Mara C, Graziella G, Gianmaria P, Francesca G. A rare case of pediatric gastric xanthoma: diagnosis and follow-up. J Gastroenterol Hepatol Res 2013;2:607-8.
  6. Halabi I, Yaseen M, Vesoulis Z, Nostrant TT. Multiple gastric xanthomas in a 3-year-old patient. Gastroenterol Hepatol 2010;6:181-4.
  7. Collins MH, Olazagasti JC, Fitzgerald J. Gastric xanthomas in a child. J Pediatr Gastroenterol Nutr 1994;19:444-7. https://doi.org/10.1097/00005176-199411000-00014
  8. Wetzler G, Felix AA, Lipton JF. Gastric xanthelasma. J Pediatr Gastroenterol Nutr 2010;51:1. https://doi.org/10.1097/MPG.0b013e3181e2c6f8

Cited by

  1. Gastric Xanthoma: An Incidental and Unusual Finding vol.73, pp.1, 2020, https://doi.org/10.1097/mpg.0000000000003085
  2. Rare Case of Gastric Xanthoma in a 15-Year-Old Patient vol.24, pp.4, 2020, https://doi.org/10.1177/10935266211007246