International Journal of Oral Biology

The Korean Academy of Oral Biology (대한구강생물학회)
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Implications of specific gene expression patterns in enamel knot in tooth development

  • Kim, Tae-Young (Department of Biochemistry, School of Dentistry, Institute for Hard Tissue and Bio-tooth Regeneration (IHBR), Kyungpook National University) ;
  • Neupane, Sanjiv (Department of Biochemistry, School of Dentistry, Institute for Hard Tissue and Bio-tooth Regeneration (IHBR), Kyungpook National University) ;
  • Aryal, Yam Prasad (Department of Biochemistry, School of Dentistry, Institute for Hard Tissue and Bio-tooth Regeneration (IHBR), Kyungpook National University) ;
  • Lee, Eui-Seon (Department of Biochemistry, School of Dentistry, Institute for Hard Tissue and Bio-tooth Regeneration (IHBR), Kyungpook National University) ;
  • Kim, Ji-Youn (Department of Dental Hygiene, College of Health Science, Gachon University) ;
  • Suh, Jo-Young (Department of Periodontology, School of Dentistry, IHBR, Kyungpook National University) ;
  • Lee, Youngkyun (Department of Biochemistry, School of Dentistry, Institute for Hard Tissue and Bio-tooth Regeneration (IHBR), Kyungpook National University) ;
  • Sohn, Wern-Joo (Pre-Major of Cosmetics and Pharmaceutics, Daegu Haany University) ;
  • An, Seo-Young (Department of Oral and Maxillofacial Radiology, School of Dentistry, IHBR, Kyungpook National University) ;
  • Ha, Jung-Hong (Department of Conservative Dentistry, School of Dentistry, IHBR, Kyungpook National University) ;
  • An, Chang-Hyeon (Department of Oral and Maxillofacial Radiology, School of Dentistry, IHBR, Kyungpook National University) ;
  • Kim, Jae-Young (Department of Biochemistry, School of Dentistry, Institute for Hard Tissue and Bio-tooth Regeneration (IHBR), Kyungpook National University)
  • Received : 2020.02.20
  • Accepted : 2020.03.18
  • Published : 2020.03.30
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Abstract

Enamel knot (EK)-a signaling center-refers to a transient morphological structure comprising epithelial tissue. EK is believed to regulate tooth development in early organogenesis without its own cellular alterations, including proliferation and differentiation. EKs show a very simple but conserved structure and share functions with teeth of recently evolved vertebrates, suggesting conserved signaling in certain organs, such as functional teeth, through the course of evolution. In this study, we examined the expression patterns of key EK-specific genes including Dusp26, Fat4, Meis2, Sln, and Zpld1 during mice embryogenesis. Expression patterns of these genes may reveal putative differentiation mechanisms underlying tooth morphogenesis.

Keywords

References

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