Ocean and Polar Research

Korea Institute of Ocean Science & Technology (한국해양과학기술원)
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Scalarane-type Sesterterpenes from the Philippines Sponge Hyrtios sp.

  • Choi, Jae-Hyeong (Marine Biotechnology Research Center, Korea Institute of Ocean Science & Technology) ;
  • Lee, Hyi-Seung (Marine Biotechnology Research Center, Korea Institute of Ocean Science & Technology) ;
  • Campos, Wilfredo L. (OceanBio Lab, University of the Philippines Visayas)
  • Received : 2020.01.22
  • Accepted : 2020.02.10
  • Published : 2020.03.30
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Abstract

The marine sponge Hyrtios sp. collected in the Philippines was extracted and partitioned. The resulting organic layer was purified by C18 reversed-phase column chromatography and HPLC to achieve the separation of nine scalarane-type sesterterpenes, including one new compound with eight known scalarane analogs. The chemical structures of the isolated compounds 1-9 were elucidated by 1D and 2D NMR and MS data analysis. All nine compounds were evaluated for their antibacterial activities against three Gram-positive and three Gram-negative bacteria. The compound 3 exhibited potent antibacterial activities against Bacillus subtilis and Micrococcus luteus. The compounds 7 and 9 displayed considerable activities against Bacillus subtilis and the others had moderate results.

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References

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