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Comparison of Usage Patterns and Outcomes by Dual Type Calcium Channel Blockers in Patients with Chronic Kidney Disease

만성 신장질환 환자에서 dual type calcium channel blocker의 사용 양상 및 결과 비교

  • Oh, Mi Ran (Department of Pharmacy, Seoul St. Mary's Hospital, The Catholic University of Korea) ;
  • Ahn, Hye Lim (Department of Pharmacy, Seoul St. Mary's Hospital, The Catholic University of Korea) ;
  • Choi, Sun (Catholic Medical Center Office of Human Research Protection) ;
  • La, Hyen Oh (College of Pharmacy, the Catholic University of Korea)
  • 오미란 (가톨릭대학교 서울성모병원 약제부) ;
  • 안혜림 (가톨릭대학교 서울성모병원 약제부) ;
  • 최선 (가톨릭중앙의료원 연구윤리사무국) ;
  • 나현오 (가톨릭대학교 약학대학)
  • Received : 2020.08.10
  • Accepted : 2020.12.12
  • Published : 2020.12.31

Abstract

Background: Dual-type calcium channel blockers (CCBs), such as efonidipine and cilnidipine, are renoprotective drugs that reportedly reduce proteinuria by dilating afferent and efferent arterioles of the glomerulus. However, studies comparing the effect of dual-type CCB on proteinuria have not been conducted. Therefore, we aimed to compare the effect of dual-type CCB (efonidipine and cilnidipine) usage patterns in hypertensive patients with chronic kidney disease (CKD). Methods: This single-center, retrospective study included 53 patients with CKD who 1) initiated efonidipine or cilnidipine treatment while on a renin-angiotensin system inhibitor and 2) had received efonidipine or cilnidipine for at least one year. We compared usage patterns between the efonidipine and cilnidipine groups during the one-year period and analyzed the following outcomes: urinary protein-to-creatinine ratio, blood pressure, and serum creatinine. Results: The study included 25 patients in the efonidipine group and 28 patients in the cilnidipine group. In both groups, blood pressure and urinary protein-to-creatinine ratios tended to decrease; however, the change during each interval was not significant. Conclusions: In patients with CKD who were on renin-angiotensin system inhibitor therapy, the addition of a dual-type CCB (i.e., efonidipine or cilnidipine) tended to reduce proteinuria; however, the change during each interval was not significant.

Keywords

References

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