Journal of Korean Medicine for Obesity Research (한방비만학회지)

The Society of Korean Medicine for obesity Research (한방비만학회)
권호 표지
DOI QR코드

DOI QR Code

Effects of Valerianae Radix et Rhizoma Methanol Extract on High-fat Diet-induced Hyperlipidemic Mice

힐초근(纈草根) 메탄올 추출물이 고지혈증 유발 생쥐의 지질대사에 미치는 영향

  • Park, Sun Mi (Department of Internal Medicine, College of Korean Medicine, Dong-Eui University) ;
  • Kim, Young Kyun (Department of Internal Medicine, College of Korean Medicine, Dong-Eui University) ;
  • Yu, Sun Ae (Department of Pediatrics, College of Oriental Medicine, Dong-Eui University) ;
  • Cho, Sung Woo (Department of Korean Rehabilitation Medicine of Korean Medicine, Dong-Eui University) ;
  • Lee, Myeong Hwa (Department of Internal Medicine, College of Korean Medicine, Dong-Eui University) ;
  • Lim, Jae Eun (Department of Acupuncture & Moxibustion Meridian & Acupoint, College of Korean Medicine, Dong-Eui University) ;
  • Kim, Kyoung Min (Department of Internal Medicine, College of Korean Medicine, Dong-Eui University)
  • 박선미 (동의대학교 한의과대학 한방내과) ;
  • 김영균 (동의대학교 한의과대학 한방내과) ;
  • 유선애 (동의대학교 한의과대학 한방소아과) ;
  • 조성우 (동의대학교 한의과대학 한방재활의학과) ;
  • 이명화 (동의대학교 한의과대학 한방내과) ;
  • 임재은 (동의대학교 한의과대학 침구의학과) ;
  • 김경민 (동의대학교 한의과대학 한방내과)
  • Received : 2020.10.31
  • Accepted : 2020.11.23
  • Published : 2020.12.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives: This study was designed to investigate the effects of Valerianae Radix et Rhizoma Methanol Extract (VRME) on serum lipid levels in a high-fat diet-induced hyperlipidemic mice. Methods: Each 8 C57BL/6 mice were randomly assigned to normal diet group, high-fat diet control group, high-fat diet plus 100 mg/kg/day of VRME group. In order to induce hyperlipidemia, high-fat diets were supplied to control group and VRME group for four weeks. Normal diet group were supplied with general feed for four weeks. After that control group supplied only high-fat diets as feed, VRME group received oral administration of VRME with high-fat diets for three weeks. and normal diet group were supplied with general feed for three weeks. After seven weeks, the changes in the body weight, the plasma levels of total cholesterol, triglyceride, high density lipoprotein-cholesterol, aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood glucose in serum were measured. Results: In our results, VRME did not affects weight gain, serum AST and ALT in high-fat diet-induced hyperlipidemic mice. Oral administration of VRME lowered levels of total cholesterol and triglyceride, which were elevated by induction of hyperlipidemia. and oral administration of VRME lowered blood glucose significantly. Conclusions: These results suggest that VRME could act as a potent antihyperlipidemic in therapeutics for hyperlipidemia.

Keywords

References

  1. Statistics Korea Annual report on the causes of death statistics [Internet]. Daejon: Statistics Korea; 2018 [cited 2019 Sep 23]. Available from: https://www.kostat.go.kr/portal/korea/kor_nw/1/6/2/index.board.
  2. World Health Organization. Cardiovascular disease risk factors; new areas of research. Geneva: WHO Press. 1994.
  3. Press release [Internet]. Wonju: National Health Insurance Service; 2017 [cited 2017 Aug 32]. Available from: https://www.nhis.or.kr/bbs7/boards/B0039/24324.
  4. Lee SH. Lipid-lowering therapy guidelines. Korean J Med. 2019 ; 94(5) : 396-402. https://doi.org/10.3904/kjm.2019.94.5.396
  5. Cheng Zh. Chinese medicine prevention and treatment of hyperlipidemia. Beijing : People's Health Publishing House. 2002 : 190-1.
  6. Chen GT, Yang SH. Practical Chinese and western medicine combined with diagnostic therapy. Beijing : China Medical Science Press. 1994 : 689, 691-2, 694-7.
  7. Soul IC, Kim BT. Effect of Kamiboyanghwanotang (KBHT) on hyperlipidemia, thrombosis, hyperviscosity, hypertension and brain damage. The Journal of Korean Oriental Chronic Disease. 1998 ; 4(1) : 133-294.
  8. Korean Food & Drug Administration. Standard manufacturing procedure guide for herbal medicine (II). Cheongju : Ministry of Food and Drug Safety. 2008 : 9.
  9. Compilation Committee. Dictionary of Chinese medicine. Seoul : Jeongdam Publishing House. 2006 : 3996-8, 5171-4.
  10. Herbology Editorial Committee of Korean Medicine Schools. Boncho-hak. Seoul : Young-Lim Press. 2011 : 722.
  11. Si X, Wu X, Jia R. Effect of valerian oil on expression of nestin in renal tubular epithel ial cells in hypercholesterolemic rats. Chinese Journal of Integrated Traditional and Western Nephrology. 2010 ; 11(6) : 486-8. https://doi.org/10.3969/j.issn.1009-587X.2010.06.006
  12. Chen L, Jia R, Ding G, Uu H, Yang D, Peng J, et al. The influence of valerian oil on oxidative stress and the activity of protein kinase C in type 2 diabeteic rat. Chinese Journal of Integrated Traditional and Western Nephrology. 2003 ; (4) : 192-5.
  13. Choi YH, Cho JH. Compositions of fatty acids, inorganic components and volatile organic acids in Korean valerian roots. Korean J Medicinal Crop Sci. 2003 ; 25(1) : 80-6.
  14. Jin HS, Jin ML, Lee MY, Park HJ, Nam JH, Hwang B, et al. Effect of elicitors on the production of valepotriates and valerenic acid in the adventitious roots of Valeriana fauriei var. dasycarpa Hara. Korean J Medicinal Crop Sci. 2007 ; 15 : 241-5.
  15. Won HS, Kim YO, Lee HY, Im HJ, Lee SH, Cho IH, et al. Effect of Valeriana fauriei extract on the neurodevelopmental proteins expression and behavioral patterns in maternal immune activation animal model. Korean J Medicinal Crop Sci. 2016 ; 24(5) : 341-50. https://doi.org/10.7783/KJMCS.2016.24.5.341
  16. Park JH, Jang TW, Lee SH. Antioxidative activities and inhibition effects on oxidative DNA damage of Valeriana fauriei. Korean J Medicinal Crop Sci. 2016 ; 24(6) : 464-70. https://doi.org/10.7783/KJMCS.2016.24.6.464
  17. Han SH, Kim HD, Jo KA, Shin JC, Suh HG. Preparation of Valerian (Valeriana officinalis) extract powder and its sleep potentiating activity. J Korean Soc Food Sci Nutr. 2018 ; 47(2) : 131-5. https://doi.org/10.3746/jkfn.2018.47.2.131
  18. Clinical Rearch Center for Stroke. Clinical practice guidelines for Storke. Seoul : Clinical Rearch Center for Stroke. 2013 : 46.
  19. Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL. Principle of Internal Medicine 16th ed. Seoul : MIP. 2006 : 2500-01, 2509-12.
  20. Lee KI, Sohn ES. Development trend of hyperlipidemia treatment medicine. Seoul : Korea Interstitute of Science and Technology Information. 2005 : 7.
  21. Ramkumar S, Raghunath A, Raghunath S. Statin therapy: review of safety and potential side effects. Acta Cardiol Sin. 2016 ; 32 : 631-9.
  22. Lee SJ. Bonchogangmok. Seoul : Komoonsa. 1983 : 491.
  23. An DK. Illustrated book of Korean medicinal herbs. Seoul : Kyohaksa. 1998 : 632.
  24. Balandrin MF, Van Wagenen BC, Corell GA. Valerian-derived sedative agentsII. Degradation of valmanederived valepotriates in ammoniated hydroaloholic tincutes. J Toxic Toxin Rev. 1995 ; 14, 165.
  25. Teychenne PF, Walters I, Claveria LE, Calne DB, Price J, Macgillivary BB, et al. The encephalopathi caction of five-carbon-atom fatty acids in the rabbit. Clin Sci Molec Med. 1976 ; 50(6) : 463-72.
  26. Sichardt K, Vissiennon Z, Koetter U, Brattstrom A, Nieber K. Modulation of postsynaptic potentials in rat cortical neurons by valerian extracts macerated with different alcohols: involvement of adenosine A(1)-and GABA(A)-receptors. Phytother Res. 2007 ; 21(10) : 932-7. https://doi.org/10.1002/ptr.2197
  27. Houghton PJ. The scientific basis for the reputed activity of valerian. J Pharm Pharmacol. 1995 ; 51 : 505. https://doi.org/10.1211/0022357991772772
  28. von Eikstedt KW, Rahman S. Psycpharmakologische wirkungen von valepotriaten. Arzeimittelforschung. 1969 ; 19 : 36-319.
  29. Hendriks H, Bos R, Allersma DP, Malinger TM, Koster ASl. Pharmacological screening of valerenal and some other components of the essential of Valeriana officinals. Planta Med. 1981 ; 42(1) : 62-8. https://doi.org/10.1055/s-2007-971547
  30. Schulz H, Stolz C, Muller J. The effect on sleep polygraphy in poor sleepers. A pilot study. Pharmacopsychiatry. 1994 ; 27(4) : 147-51. https://doi.org/10.1055/s-2007-1014295
  31. Donath F, Quispe S, Diefenbach K, Maurer A, Fietze I, Roots I. Critical evaluation of the effect of valerian extract on sleep structure and sleep quality. Pharmacopsychiatry. 2000 ; 33(2) : 47-53. https://doi.org/10.1055/s-2000-7972
  32. Park HJ, Lee SH. Studies on the components of valerian and isovaleramide. J Pharm Soc Korea. 2010 ; 54(1) : 1-7.
  33. Oliveira MJA, van Deventer HE, Bachmann LM, Warnick GR, Nakajima K, NaKamura M, et al. Evaluation of four different equations for calculating LDL-C with eight different direct HDL-C assays. Clin Chim Acta. 2013 ; 423 : 135-40. https://doi.org/10.1016/j.cca.2013.04.009
  34. Lee EH, Chyun JH. Effects of chongkukjang intake on lipid metabolism and liver functionin ethanol consumed rats. J Nutr Health. 2007 ; 40(8) : 689-90.
  35. Calitz C, du Plessis L, Gouws C, Steyn D, Steenekamp J, Muller C, et al. Herbal hepatotoxicity: current status, examples, and challenges. Expert Opinion on Drug Metabolism & Toxicology. 2015 ; 11(10) : 1551-65. https://doi.org/10.1517/17425255.2015.1064110