한국응용과학기술학회지 (Journal of the Korean Applied Science and Technology)

  • 제37권1호
  • /
  • Pages.66-75
  • /
  • 2020
  • /
  • 1225-9098(pISSN)
  • /
  • 2288-1069(eISSN)
한국응용과학기술학회 (The Korean Society of Applied Science and Technology)
권호 표지
DOI QR코드

DOI QR Code

하수오 추출물(Polygonum multiflorum)이 아토피 피부염 유발 NC/Nga 생쥐의 알레르기 반응에 미치는 영향

Effect of Polygonum multipolarum extract on the allergic reaction of NC/Nga mice causing atopic dermatitis

  • 문지선 (중원대학교 의료뷰티케어학과) ;
  • 최은영 (알엑스에이피코리아)
  • 투고 : 2020.02.08
  • 심사 : 2020.02.21
  • 발행 : 2020.02.28
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Atopic dermatitis (AD) usually develops in patients with an individual or family history of allergic diseases, and is characterized by chronic relapsing inflammation seen specially in childhood, association with IgE hyperproduction and precipitation by environmental factors. and wished to examine closely effect that Polygonum multiflorum isolated PM-E and PM-70M orally adminstration used to atopy dermatitis disease patient get in atopy eruption control experimentally. Atopic dermatitis is a chronically relapsing inflammatory skin disease. Animal models induced by relevant allergens play a very important role in the elucidation of the disease. This study was investigated the anti-allergic effect of PM-E and PM-70M on BMAC induced atopic dermatitis in NC/Nga mice. We summerized as the follow. PM-E and PM-70M significantly reduced the skin number of total cell number, CD4+ and CD11b+/Gr-1 cell compared with positive control and decreased the invasion of CD4+ cell in dorsal skin tissue compared with positive control group by using immunohistochemical staining and chemokine such as eotaxin and CCR3 compared with positive control group. PM-E and PM-70M markedly suppressed invasion and edema of leukocytes and mast cell in dorsal skin. Taken together, these findings suggested that PM-E and PM-70M has an anti-allergic activity and this might be useful for the clinical application to treat allergic diseases such as atopic dermatitis.

키워드

참고문헌

  1. B. Andrew, T. H. Sam, C. U. Mark, "Allergic and immunologic disease of the skin", Journal of Allergy and Clinical Immunology. Vol.111, pp.560-570, (2003). https://doi.org/10.1067/mai.2003.78
  2. J. A. Bellanti, "Cytokines and allergic diseases: clinical aspects", Allergy and Asthma Proceedings, Vol.19 No.6, pp. 337-41, (1998). https://doi.org/10.2500/108854198778612735
  3. B. Huang, P. Y. Pan, L. I. Qingsheng, I. S. Alice, E. David, L. Jonathan Bromberg, C. M. Divino, S. H. Chen. "$Gr-1^{+}CD115^{+}$ Immature Myeloid Suppressor Cells Mediate the Development of Tumor-Induced T Regulatory Cells and T-Cell Anergy in Tumor-Bearing Host", Cancer Research, Vol.15, No.66, pp. 1123-1131, (2006).
  4. M. K, Church, J. Hiroi, "Inhibition of IgE-dependent histamine release from human dispersed lung mast cells by anti-allergic drugs and salbutamol", British Journal of Pharmacology, Vol. 90, No.2, pp. 421-429, (1987). https://doi.org/10.1111/j.1476-5381.1987.tb08972.x
  5. W. W. Danniel, "A foundation for analysis in the health science", Biostics, pp. 136-146, (1983).
  6. S. Dong, S. H. Jung, J. S. Moon, S. K. Rhee, J. Y. Son "Antioxidant activities of clove by extraction solvent", Journal of the Korean Society of Food Science and Nutrition, Vol. 33, No.4, pp. 609-613, (2004). https://doi.org/10.3746/jkfn.2004.33.4.609
  7. M. Ebtekar, "Effects of Persistent Organic Pollutants on the Immune System: The Case of Dioxins", Journal of Environmental Health Science & Engineering, Vol.1, No.2, pp.1-7, (2004).
  8. E. Gonzalez-Rey, A. Chorny, M. Delgado, "Regulation of immune tolerance by anti-inflammatory neuropeptides", Nature Reviews Immunology, Vol.7, No.1, 52-63, (2007). https://doi.org/10.1038/nri1984
  9. J. M. Hanifin, "Atopic dermatitis: broadening the perspective", Journal of the American Academy of Dermatology, Vol.51, No.1, pp. 23-24, (2004). https://doi.org/10.1016/j.jaad.2004.01.010
  10. U. Hoffler, K. Oette, "Comparative studies on four thrombocyte counting methods: counting in the smear preparation after Fonio, chamber counting in the phase contrast microscope, counting with the Coulter Thrombocounter, and the Technicon Auto-Counter", Zeitschrift fur klinische Chemie und klinische Biochemie, Vol.12, No.5, pp. 198-206, (1974).
  11. H. Matsuda, N. Watanabe, G. P. Geba, J. Sperl, M. Tsudzuki, J. Hiroi, M. Matsumoto, H. Ushio, S. Saito, P. W. Askenase and C. Ra. "Development of atopic dermatitis-like skin lesion with IgE hyperproduction in NC/Nga mice", International Immunology, Vol.9, No.3, pp. 461-466, (1997). https://doi.org/10.1093/intimm/9.3.461
  12. S. M. Wilkinson, J. Brittain, M. H. Beck, "Allergic contact dermatitis from an anthraquinone derivative in a chemical plant", Contact Dermatitis, Vol.30, No.4, pp. 241-242, (2006). https://doi.org/10.1111/j.1600-0536.1994.tb00654.x
  13. K. Johrens, I. Anagnostopoulos, H. Durkop, H. Stein, "Different T-bet expression patteerns characterize particular reactive lymphoid tissue lesions", Histopathology, Vol.48, No.4, pp. 343-352, (2006). https://doi.org/10.1111/j.1365-2559.2005.02305.x
  14. H. S. Lee, S. K. Kim, J. B. Han, H. M. Choi, J. H. Park, E. C. Kim, M. S. Choi, H. J. An, J. Y. Um, H. M. Kim, B. I. Min. "Inhibitory effects of Rumex japonicus Houtt. on the development of atopic dermatitis-like skin lesions in NC/Nga mice", British Journal of Dermatology, Vol.155, No.1, pp. 33-38 (2006). https://doi.org/10.1111/j.1365-2133.2006.07303.x
  15. W. Ma, P. J. Bryce, A. A. Humbles, D. Laouini, A. Yalcindag, H. Alenius, D. S. Friend, H. C. Oettgen, C, Gerard, R. S. Geha, "CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation", The Journal of clinical investigation, Vol.109, No.5, pp. 621-8, (2002). https://doi.org/10.1172/JCI0214097
  16. Y. Hashimoto, I. Arai, Y. Nakanishi, T. Sakurai, "Atsushi Nakamura. : Scratching of their skin by NC/Nga mouse leads to development of dermatitis", Life Sciences, Vol.76, No.7, pp. 783-794, (2004). https://doi.org/10.1016/j.lfs.2004.07.022