Journal of Marine Bioscience and Biotechnology (한국해양바이오학회지)

The Korean Society for Marine Biotechnology (한국해양바이오학회)
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Polysiponia morrowii Extract Inhibits Cancer Growth on CT-26 and Hela cells

  • Zhang, Chunying (Department of Integrated of Bioindustry, Hanseo University) ;
  • Cha, Seon-Heui (Department of Integrated of Bioindustry, Hanseo University)
  • Received : 2020.11.24
  • Accepted : 2020.12.24
  • Published : 2020.12.31
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Abstract

Cancer is an unfavorable human disease, and the treatment commonly have side effects and can be ineffective. Since exploration and development of cancer treatment drugs is particularly demanding, this study aimed to investigate the anticancer activities of Polysiponia morrowii extract s (PME) on CT-26 and HeLa cells. The results showed that PME inhibited cell proliferation in a dose-dependent manner, with IC50 values of 41.04% in CT-26 and 48.51% in HeLa cell cultures. Moreover, cytological observation using Hoechst 33342 staining assay showed typical apoptotic morphology in both cancer cells, and production of sub-G1 DNA was induced by PME treatment in a dose-dependent manner, with 34.41% in CT-26 and 46.01% in HeLa cell cultures. These findings suggest that PME may have potential preventive effects or medicinal value in the treatment of colorectal and cervical cancers.

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References

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