Journal of Marine Bioscience and Biotechnology (한국해양바이오학회지)

The Korean Society for Marine Biotechnology (한국해양바이오학회)
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Inhibitory Effect of Osteoclastogenesis and Estradiol Activity of Myelophycus simplex Extract

바위수염 추출물의 파골세포 분화 억제 및 에스트라디올 활성 평가

  • Ha, Hyun Joo (Department of Food Science & Nutrition, Dong-A University) ;
  • Lim, Hyung Jin (Immunoregulatory Material Research Center, Korea Institute of Bioscience and Biotechnology) ;
  • Kim, Min Gyeong (Department of Food Biotechnology, University of Science and Technology) ;
  • Bak, Seon Gyeong (Immunoregulatory Material Research Center, Korea Institute of Bioscience and Biotechnology) ;
  • Rho, Mun-Chual (Immunoregulatory Material Research Center, Korea Institute of Bioscience and Biotechnology) ;
  • Cheong, Sun Hee (Department of Marine Bio Food Science, Chonnam National University) ;
  • Lee, Seung-Jae (Immunoregulatory Material Research Center, Korea Institute of Bioscience and Biotechnology) ;
  • Lee, Sang-Hoon (Division of Food Functionality Research, Korea Food Research Institute)
  • 하현주 (동아대학교 식품영양학과) ;
  • 임형진 (한국생명공학연구원 면역조절소재연구센터) ;
  • 김민경 (과학기술연합대학원대학교 식품생명공학전공) ;
  • 박선경 (한국생명공학연구원 면역조절소재연구센터) ;
  • 노문철 (한국생명공학연구원 면역조절소재연구센터) ;
  • 정선희 (전남대학교 해양바이오식품학과) ;
  • 이승재 (한국생명공학연구원 면역조절소재연구센터) ;
  • 이상훈 (한국식품연구원 식품기능연구본부)
  • Received : 2020.08.07
  • Accepted : 2020.08.26
  • Published : 2020.12.31
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Abstract

In the present study, the estrogenic activity and anti-osteoclastogenic activity of the Myelophycus simplex extract were evaluated using T47D-Kbluc cells and bone marrow-derived macrophages (BMMs). As a result of the measurement of the estrogenic activity in the T47D-Kbluc cell line, the Myelophycus simplex extract showed increased estrogenic activity in a dose-dependent manner in association with its concentration. To confirm the regulatory effect of the Myelophycus simplex extract on the estrogen-responsive gene, the Myelophycus simplex extract showed a similar tendency to estradiol: the expression of estrogen receptor 1 (ESR1) was significantly decreased while the expression of estrogen receptor 2 (ESR2) was increased. Furthermore, the Myelophycus simplex extract exhibited an inhibitory effect on osteoclast differentiation. In conclusion, these Myelophycus simplex extracts might be regarded as candidates for further studies or the development of functional food products or medicine to prevent or avoid postmenopausal symptoms for women.

Keywords

References

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