DOI QR코드

DOI QR Code

Antimicrobial and Immunomodulatory Effects of Bifidobacterium Strains: A Review

  • 투고 : 2020.08.02
  • 심사 : 2020.10.18
  • 발행 : 2020.12.28

초록

Bifidobacterium strains can provide several health benefits, such as antimicrobial and immunomodulatory effects. Some strains inhibit growth or cell adhesion of pathogenic bacteria, including multidrug-resistant bacteria, and their antibacterial activity can be intensified when combined with certain antibiotics. In addition, some strains of bifidobacteria reduce viral infectivity, leading to less epithelial damage of intestinal tissue, lowering the virus shedding titer, and controlling the release of antiviral substances. Furthermore, bifidobacteria can modulate the immune system by increasing immunoglobulins, and inducing or reducing pro- or anti-inflammatory cytokines, respectively. In particular, these anti-inflammatory effects are helpful in the treatment of patients who are already suffering from infection or inflammatory diseases. This review summarizes the antimicrobial effects and mechanisms, and immunomodulatory effects of Bifidobacterium strains, suggesting the potential of bifidobacteria as an alternative or complementary treatment option.

키워드

참고문헌

  1. Cortesia C, Vilcheze C, Bernut A, Contreras W, Gomez K, de Waard J, et al. 2014. Acetic Acid, the active component of vinegar, is an effective tuberculocidal disinfectant. mBio 5: e00013-14.
  2. Fraise AP, Wilkinson MA, Bradley CR, Oppenheim B, Moiemen N. 2013. The antibacterial activity and stability of acetic acid. J. Hosp. Infect. 84: 329-331. https://doi.org/10.1016/j.jhin.2013.05.001
  3. Turroni F, Peano C, Pass DA, Foroni E, Severgnini M, Claesson MJ, et al. 2012. Diversity of bifidobacteria within the infant gut microbiota. PLoS One 7: e36957. https://doi.org/10.1371/journal.pone.0036957
  4. Mitsou EK, Kirtzalidou E, Oikonomou I, Liosis G, Kyriacou A. 2008. Fecal microflora of Greek healthy neonates. Anaerobe 14: 94-101. https://doi.org/10.1016/j.anaerobe.2007.11.002
  5. Balakrishnan RS. 2007. The normal bacterial flora of the human intestine and its regulation. J. Clin. Gastroenterol. 41: S2-S6
  6. DuPont AW, DuPont HL. 2011. The intestinal microbiota and chronic disorders of the gut. Nat. Rev. Gastroenterol. Hepatol. 8: 523-531. https://doi.org/10.1038/nrgastro.2011.133
  7. Inturri R, Stivala A, Furneri PM, Blandino G. 2016. Growth and adhesion to HT-29 cells inhibition of Gram-negatives by Bifidobacterium longum BB536 e Lactobacillus rhamnosus HN001 alone and in combination. Eur. Rev. Med. Pharmacol. Sci. 20: 4943-4949.
  8. Lee DK, Park SY, An HM, Kim JR, Kim MJ, Lee SW, et al. 2011. Antimicrobial activity of Bifidobacterium spp. isolated from healthy adult Koreans against cariogenic microflora. Arch. Oral Biol. 56: 1047-1054. https://doi.org/10.1016/j.archoralbio.2011.03.002
  9. Lee DK, Kim MJ, Ham JW, An HM, Cha MK, Lee SW, et al. 2012. In vitro evaluation of antibacterial activities and anti-inflammatory effects of Bifidobacterium spp. addressing acne vulgaris. Arch. Pharm. Res. 35: 1065-1071. https://doi.org/10.1007/s12272-012-0614-9
  10. Munoz-Quezada S, Chenoll E, Vieites JM, Genoves S, Maldonado J, Bermudez-Brito M, et al. 2013. Isolation, identification and characterisation of three novel probiotic strains (Lactobacillus paracasei CNCM I-4034, Bifidobacterium breve CNCM I-4035 and Lactobacillus rhamnosus CNCM I-4036) from the faeces of exclusively breast-fed infants. Br. J. Nutr. 109: S51-S62 https://doi.org/10.1017/S0007114512005211
  11. Abdelhamid AG, Esaam A, Hazaa MM. 2018. Cell free preparations of probiotics exerted antibacterial and antibiofilm activities against multidrug resistant E. coli. Saudi Pharm. J. 26: 603-607. https://doi.org/10.1016/j.jsps.2018.03.004
  12. Yoon JH, Kim YA, Song MS, Kang BY, Ha NJ. 2006. Lactic acid bacteria isolated from healthy Korean having antimicrobial activity against VISA and VRE. Yakhak Hoeji 50: 78-83.
  13. Lkhagvadorj E, Nagata S, Wada M, Bian L, Wang C, Chiba Y, et al. 2010. Anti-infectious activity of synbiotics in a novel mouse model of methicillin-resistant Staphylococcus aureus infection. Microbiol. Immunol. 54: 265-275. https://doi.org/10.1111/j.1348-0421.2010.00224.x
  14. Yang J, Yang H. 2018. Effect of Bifidobacterium breve in combination with different antibiotics on Clostridium difficile. Front. Microbiol. 9: 2953. https://doi.org/10.3389/fmicb.2018.02953
  15. Toscano M, De Grandi R, Stronati L, De Vecchi E, Drago L. 2017. Effect of Lactobacillus rhamnosus HN001 and Bifidobacterium longum BB536 on the healthy gut microbiota composition at phyla and species level: a preliminary study. World J. Gastroenterol. 23: 2696-2704. https://doi.org/10.3748/wjg.v23.i15.2696
  16. Parashar UD, Hummelman EG, Bresee JS, Miller MA, Glass RI. 2003. Global illness and deaths caused by rotavirus disease in children. Emerg. Infect. Dis. 9: 565-572. https://doi.org/10.3201/eid0905.020562
  17. Gagnon M, Vimont A, Darveau A, Fliss I, Jean J. 2016. Study of the ability of bifidobacteria of human origin to prevent and treat rotavirus infection using colonic cell and mouse models. PLoS One 11: e0164512. https://doi.org/10.1371/journal.pone.0164512
  18. Ishizuka T, Kanmani P, Kobayashi H, Miyazaki A, Soma J, Suda Y, et al. 2016. Immunobiotic bifidobacteria strains modulate rotavirus immune response in porcine intestinal epitheliocytes via pattern recognition receptor signaling. PLoS One 11: e0152416. https://doi.org/10.1371/journal.pone.0152416
  19. Vlasova AN, Chattha KS, Kandasamy S, Liu Z, Esseili M, Shao L, et al. 2013. Lactobacilli and bifidobacteria promote immune homeostasis by modulating innate immune responses to human rotavirus in neonatal gnotobiotic pigs. PLoS One 8: e76962. https://doi.org/10.1371/journal.pone.0076962
  20. Munoz JA, Chenoll E, Casinos B, Bataller E, Ramon D, Genoves S, et al. 2011. Novel probiotic Bifidobacterium longum subsp. infantis CECT 7210 strain active against rotavirus infections. Appl. Environ. Microbiol. 77: 8775-8783. https://doi.org/10.1128/AEM.05548-11
  21. Holscher HD, Czerkies LA, Cekola P, Litov R, Benbow M, Santema S, et al. 2012. Bifidobacterium lactis Bb12 enhances intestinal antibody response in formula-fed infants: a randomized, double-Blind, controlled trial. J. Parenter. Enteral. Nutr. 36: 106S-117S. https://doi.org/10.1177/0148607111430817
  22. Wang LQ, Zhao F, Liu F, Meng XC. 2013. Live/dead state is not the factor influencing adhesion ability of Bifidobacterium animalis KLDS2.0603. J. Microbiol. 51: 584-589. https://doi.org/10.1007/s12275-013-2632-9
  23. Natividad JM, Hayes CL, Motta JP, Jury J, Galipeau HJ, Philip V, et al. 2013. Differential induction of antimicrobial REGIII by the intestinal microbiota and Bifidobacterium breve NCC2950. Appl. Environ. Microbiol. 79: 7745-7754. https://doi.org/10.1128/AEM.02470-13
  24. El Kfoury KA, Romond MB, Scuotto A, Alidjinou EK, Dabboussi F, Hamze M, et al. 2017. Bifidobacteria-derived lipoproteins inhibit infection with coxsackievirus B4 in vitro. Int. J. Antimicrob. Agents 50: 177-185. https://doi.org/10.1016/j.ijantimicag.2017.03.010
  25. Fernandez-Duarte KP, Olaya-Galan NN, Salas-Cardenas SP, Lopez-Rozo J, Gutierrez-Fernandez MF. 2018. Bifidobacterium adolescentis (DSM 20083) and Lactobacillus casei (Lafti L26-DSL): probiotics able to block the in vitro adherence of rotavirus in MA104 cells. Probiotics Antimicrob. Proteins 10: 56-63. https://doi.org/10.1007/s12602-017-9277-7
  26. Lee A, Lee YJ, Yoo HJ, Kim M, Chang Y, Lee DS, et al. 2017. Consumption of dairy yogurt containing Lactobacillus paracasei ssp. paracasei, Bifidobacterium animalis ssp. lactis and heat-treated Lactobacillus plantarum improves immune function including natural killer cell activity. Nutrients 9: 558. https://doi.org/10.3390/nu9060558
  27. Han S, Cho K, Lee CK, Song Y, Park SH, Ha NJ, et al. 2005. Enhancement of antigen presentation capability of dendritic cells and activation of macrophages by the components of Bifidobacterium pseudocatenulatum SPM 1204. J. Appl. Pharmacol. 13: 174-180.
  28. Nakamura Y, Terahara M, Iwamoto T, Yamada K, Asano M, Kakuta S, et al. 2012. Upregulation of polymeric immunoglobulin receptor expression by the heat-inactivated potential probiotic Bifidobacterium bifidum OLB6378 in a mouse intestinal explant model. Scand. J. Immunol. 75: 176-183. https://doi.org/10.1111/j.1365-3083.2011.02645.x
  29. Chae JM, Heo W, Cho HT, Lee DH, Kim JH, Rhee MS, et al. 2018. Effects of orally-administered Bifidobacterium animalis subsp. lactis strain BB12 on dextran sodium sulfate-induced colitis in mice. J. Microbiol. Biotechnol. 28: 1800-1805. https://doi.org/10.4014/jmb.1805.05072
  30. Khokhlova EV, Smeianov VV, Efimov BA, Kafarskaia LI, Pavlova SI, Shkoporov AN. 2012. Anti-inflammatory properties of intestinal Bifidobacterium strains isolated from healthy infants. Microbiol. Immunol. 56: 27-39. https://doi.org/10.1111/j.1348-0421.2011.00398.x
  31. Rodes L, Khan A, Paul A, Coussa-Charley M, Marinescu D, Tomaro-Duchesneau C, et al. 2013. Effect of probiotics Lactobacillus and Bifidobacterium on gut-derived lipopolysaccharides and inflammatory cytokines: an in vitro study using a human colonic microbiota model. J. Microbiol. Biotechnol. 23: 518-526. https://doi.org/10.4014/jmb.1205.05018
  32. Sheikhi A, Shakerian M, Giti H, Baghaeifar M, Jafarzadeh A, Ghaed V, et al. 2016. Probiotic yogurt culture Bifidobacterium animalis subsp. lactis BB-12 and Lactobacillus acidophilus LA-5 modulate the cytokine secretion by peripheral blood mononuclear cells from patients with ulcerative colitis. Drug Res. (Stuttg) 66: 300-305. https://doi.org/10.1055/s-0035-1569414
  33. Silva AKS, Silva TRN, Nicoli JR, Vasquez-Pinto LMC, Martins FS. 2018. In vitro evaluation of antagonism, modulation of cytokines and extracellular matrix proteins by Bifidobacterium strains. Lett. Appl. Microbiol. 67: 497-505. https://doi.org/10.1111/lam.13062
  34. Vieira AT, Rocha VM, Tavares L, Garcia CC, Teixeira MM, Oliveira SC, et al. 2016. Control of Klebsiella pneumoniae pulmonary infection and immunomodulation by oral treatment with the commensal probiotic Bifidobacterium longum 51A. Microbes Infect. 18: 180-189. https://doi.org/10.1016/j.micinf.2015.10.008

피인용 문헌

  1. Safety Evaluation of Bifidobacterium breve IDCC4401 Isolated from Infant Feces for Use as a Commercial Probiotic vol.31, pp.7, 2021, https://doi.org/10.4014/jmb.2103.03041
  2. The Role of the PFNA Operon of Bifidobacteria in the Recognition of Host’s Immune Signals: Prospects for the Use of the FN3 Protein in the Treatment of COVID-19 vol.22, pp.17, 2021, https://doi.org/10.3390/ijms22179219
  3. KDP, a Lactobacilli Product from Kimchi, Enhances Mucosal Immunity by Increasing Secretory IgA in Mice and Exhibits Antimicrobial Activity vol.13, pp.11, 2020, https://doi.org/10.3390/nu13113936