Journal of Food Hygiene and Safety (한국식품위생안전성학회지)

The Korean Society of Food Hygiene and Safety (한국식품위생안전성학회)
권호 표지
DOI QR코드

DOI QR Code

A study on Illegal Compounds and Heavy Metals in Dietary Supplements

다이어트 보조식품에 대한 부정물질 및 중금속 실태 조사

  • Lee, Yu-Na (Food Additives Analysis Team, Gyeonggi Province Institute of Health and Environment) ;
  • Kim, Myung-Gil (Food Additives Analysis Team, Gyeonggi Province Institute of Health and Environment) ;
  • Kim, Jae-Kwan (Food Additives Analysis Team, Gyeonggi Province Institute of Health and Environment) ;
  • Seo, Mi-Young (Food Additives Analysis Team, Gyeonggi Province Institute of Health and Environment) ;
  • Lim, Kyoung-Suk (Food Additives Analysis Team, Gyeonggi Province Institute of Health and Environment) ;
  • Ku, Eun-Jung (Food Additives Analysis Team, Gyeonggi Province Institute of Health and Environment) ;
  • Chae, Sun-Young (Food Additives Analysis Team, Gyeonggi Province Institute of Health and Environment) ;
  • Jang, Hye-Lim (Food Additives Analysis Team, Gyeonggi Province Institute of Health and Environment) ;
  • Yoon, Mi-Hye (Food Additives Analysis Team, Gyeonggi Province Institute of Health and Environment)
  • 이유나 (경기도보건환경연구원 식품의약품연구부 첨가물분석팀) ;
  • 김명길 (경기도보건환경연구원 식품의약품연구부 첨가물분석팀) ;
  • 김재관 (경기도보건환경연구원 식품의약품연구부 첨가물분석팀) ;
  • 서미영 (경기도보건환경연구원 식품의약품연구부 첨가물분석팀) ;
  • 임경숙 (경기도보건환경연구원 식품의약품연구부 첨가물분석팀) ;
  • 구은정 (경기도보건환경연구원 식품의약품연구부 첨가물분석팀) ;
  • 채선영 (경기도보건환경연구원 식품의약품연구부 첨가물분석팀) ;
  • 장혜림 (경기도보건환경연구원 식품의약품연구부 첨가물분석팀) ;
  • 윤미혜 (경기도보건환경연구원 식품의약품연구부 첨가물분석팀)
  • Received : 2020.10.05
  • Accepted : 2020.11.09
  • Published : 2020.12.30
Download PDF
⟨ Previous Next ⟩

Abstract

In this study, we investigated the illegal hazardous compounds in dietary supplements. We analyzed the contents of anti-obesity drugs, their analogues (orlistat, sibutramine, desmethylsibutramine, didesmethylsibutramine, chlorosibutramine, chlorosipentramine) and three heavy metals (lead (Pb), cadmium (Cd), arsenic (As)) in 62 other processed products (n=32), candies (n=7), weight control foods (n=10) and teas (n=13). Anti-obesity drugs or their analogues were not detected in any of the 62 samples. Three heavy metals (Pb, Cd, As) were detected in the range of ND-0.177 mg/kg, 0.002-0.233 mg/kg and 0.001-0.188 mg/kg in teas, ND-0.370 mg/kg, 0.003-0.057 mg/kg and 0.007-0.120 mg/kg in candies, ND-0.055 mg/kg, 0.012-0.045 mg/kg and 0.010-0.163 mg/kg in weight control foods, respectively. Heavy metals (Pb, Cd, As) were detected in the range of ND-2.324 mg/kg, 0.004-0.936 mg/kg and 0.003-21.247 mg/kg in other processed products that are not regulated by specification standards according to food types. These results show that regulations of heavy metals is required in other processed products for genuine food safety.

본 연구는 현재 유통 중인 다이어트 제품 62건에 대한 부정유해물질의 실태조사를 위하여 비만치료제 및 그 유사물질 6종(오르리스타트, 시부트라민, 데스메틸시부트라민, 디데스메틸시부트라민, 클로로시부트라민, 클로로시펜트라민)과 중금속(납, 카드뮴, 비소) 함량을 조사하였다. 연구결과, 다이어트 제품 62건에 대하여 비만치료제 및 그 유사물질 6종은 검출되지 않았다. 중금속은 납, 카드뮴, 비소 각각 다류의 경우 ND-0.177 mg/kg, 0.002-0.233 mg/kg, 0.001-0.188 mg/kg, 캔디류의 경우 ND-0.370 mg/kg, 0.003-0.057 mg/kg, 0.007-0.120 mg/kg, 체중조절용조제식품의 경우 ND-0.055 mg/kg, 0.012-0.045 mg/kg, 0.010-0.163 mg/kg의 함량을 나타냈다. 기준 규격이 설정되어있지 않은 기타가공식품의 경우 납, 카드뮴, 비소 각각 ND-2.324 mg/kg, 0.004-0.936 mg/kg, 0.003-21.247 mg/kg의 함량을 보였으며, 비소의 경우 2건이 PTWI 기준치 이상의 수치를 보였다. 결과적으로 식품군의 안전관리를 위하여 향후 기준 규격이 없는 기타가공식품 유형에 대한 적절한 기준 설정이 필요할 것으로 사료된다.

Keywords

References

  1. Ministry of Health and Welfare, 2016, Korea Health Statistics 2016: Korea National Health and Nutrition Examination Survey 7ed. Cheongju, Korea, pp. 94-833.
  2. Ahn, B.J., Development situation of dietary food. Food industry and nutrition., 4(1), 36-44 (1999).
  3. Han, C.J., Study on Perception of Weight Control and Patterns of Diet/Low-Calorie Food Consumption according to Weight Status in Adult Women. J. East. Asian. Soc. Diet. Life., 27(2), 104-113 (2017). https://doi.org/10.17495/easdl.2017.4.27.2.104
  4. Kang, N.E., Ha, A.W., Yi, S.H., The Patterns of Purchasing Diet/Low-Calorie Food and Obesity Related Eating Behavior in Normal and Obese Female College Students in Seoul Area. Kor. J. Food Nutri., 22(4), 650-661 (2009).
  5. Yun, J.S., Choi, J.D., Kwon, K.S., Jo, C.H., Screening of anti-obesity drugs, their analogues and prohibited ingredients in slimming foods. Korean Journal of Food Science and Technology, 48(5), 424-429 (2016). https://doi.org/10.9721/KJFST.2016.48.5.424
  6. Balcioglu, A., Wurtman, R.J., Sibutramine, a serotonin uptake inhibitor, increases dopamine concentrations in rat striatal and hypothalamic extracellular fluid. Neuropharmacology, 39(12), 2352-2359 (2000). https://doi.org/10.1016/S0028-3908(00)00083-6
  7. Luque, C.A., Rey, J.A., The discovery and status of sibutramine as an anti-obesity drug. Eur. J. Pharmacol., 440(2-3), 119-128 (2001). https://doi.org/10.1016/S0014-2999(02)01423-1
  8. Son, E.H., In, S.W., Kim, B.O., Pyo, S.N., Anti-Obesity Drugs : A Current Research Insight. J. Biomed. Sci., 11, 89-101 (2005).
  9. Ministry of Food and Drugs Safety, 2018, Food Code, Cheongju, Korea. pp. 79-260.
  10. Ministry of Food and Drugs Safety, 2018, Food and Drug Statistical Yearbook, Cheongju, Korea. pp. 108-307.
  11. Reilly, C., 1991. Metal contamination of Food. 3rd edition, Oxford, UK. pp. 81-195.
  12. Chung, S.Y., Kim, J.S., Kim, E.J., Park, S.K., Kim, M.H., Hong, M.K., Kim, M.C., Lee, J.O., Trace Metal Contents in tea Products and Their Safety Evaluations. Kor. J. Food Sci. Technol., 35(5), 812-817 (2003).
  13. Jang, J.S., Kwon, M.j., Kim, M.H., Park, J.S., Lim, S.S., Kwon, S.W., Song, S.M., Yeo, E.Y., Hong, S.H., Kim, J.i., Om, A.S., Other Processed Products, Monitoring and the Exposed Dose Assessment of Heavy Metal. the Illegal Compounds. J. Food Hyg. Saf., 30(1), 35-42 (2015). https://doi.org/10.13103/JFHS.2015.30.1.35
  14. Kim, S.D., Jung, S.O., Kim, B.S., Yun, E.S., Chang, M.S., Park, Y.A., Lee, Y.C., Chae, Y.Z., Kim, M.Y., The Content of Heavy Metals in Herbal Pills Used as General Processed Food and Risk Assessment of Heavy Metal Intakes. J Kor. Soc. Food Sci. Nutr., 39(7), 1038-1048 (2010). https://doi.org/10.3746/JKFN.2010.39.7.1038
  15. Wu, Y,. 2014. General standard for contaminants and toxins in food and feed (codex stan 193-1995), Beijing, China. pp. 30-35.
  16. Kim, E.H., Yoon, Y.S., Lee, J.H., Heo, Y.J., Kwon, M.W., Park, N.H., Hong, J.K., Analytical trends on screening of illegal adulterants in supplementary diets. Anal. Sci. Technol., 30(6), 309-404 (2017).
  17. Campbell-Platt, G., 2017. Food Science and Technology. 2nd edition, John Wiley & Sons, Newjersey, USA, pp. 325-437.
  18. JFAO/WHO, 1994. Summary of evaluations performed by the Joint FAO/WHO Expert Committee on Food Additives, Geneva, Swizerland.